We present an application of Defect Oriented Testing (DOT 1 ) to an industrial mixed signal device to reduce test time and maintain quality. The device is an automotive IC product with stringent quality requirements and a mature test program that is already in volume production. A complete flow is presented including defect extraction, defect simulation, test selection, and validation. A major challenge of DOT for mixed signal devices is the simulation time. We address this challenge with a new fault simulation algorithm that provides significant speedup in the DOT process. Based on the fault simulations, we determine a minimal set of tests which detects all defects. The proposed minimal test set is compared with the actual test results of more than a million ICs. We prove that the production tests of the device can be reduced by at least 35%.