Predatory bacterial hydrogels for topical treatment of infected wounds

Liu, Yan; Zhuang, B. A.; Yuan, Bochuan; Zhang, Hui; Li, Jingfei; Wang, Wanmei; Li, Ruiteng; Du, Lina; Ding, Pingtian; Jin, Yiguang

doi:10.1016/j.apsb.2022.05.005

Cited by 32 publications

(11 citation statements)

References 61 publications

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“…The biocompatibility of nanoparticles was first verified by cytotoxicity assay. Here, to evaluate the cytotoxicity in wound repair, mouse fibroblasts L929 cells were chosen according to relevant literature . Cur-Free has dose-dependent cytotoxicity, and the IC50 value was about 25 μM .…”

Section: Resultsmentioning

confidence: 99%

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Hyaluronic Acid-Modified ZIF-8 Nano-Vehicle for Self-Adaption Release of Curcumin for the Treatment of Burns

Wang

Fan

Guan

et al. 2022

ACS Appl. Nano Mater.

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Scarring is caused by excessive medical treatment in the tissue remodeling stage; hence, the need for medication is not constant throughout the stage of burn recovery. In this study, we construct a nano self-adaption release system (Cur-ZIF8-HA) using hyaluronic acid (HA)-modified zeolite-imidazole-frame-8 (ZIF-8) as the nano-vehicle and curcumin (Cur) as the bioactive compound for the treatment of burns. The release of Cur within 48 h in the media of pH 8.5, pH 6.0, and pH 7.4 was 13.94, 54.05, and 20.17%, which could realize antibacterial functions in the inflammation stage, wound healing in the tissue proliferation/formation stage, and prevention of excessive fibroblast development and aberrant extracellular matrix deposition in the remodeling stage. Based on this property, Cur-ZIF8-HA has superior efficacy in healing bacterially infected burn wounds in vivo. This work provides a self-adaption release system with antibacterial wound-healing properties and prevents scarring functional based on the ZIF8-HA nano-vehicle, which opens a new way for the clinical application of curcumin for burn healing.

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Section: Resultsmentioning

confidence: 99%

“…Here, to evaluate the cytotoxicity in wound repair, mouse fibroblasts L929 cells were chosen according to relevant literature. 31 Cur-Free has dose-dependent cytotoxicity, and the IC50 value was about 25 μM. 32 In wound repair studies, concentrations should theoretically be selected to be below their IC50 values.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Hyaluronic Acid-Modified ZIF-8 Nano-Vehicle for Self-Adaption Release of Curcumin for the Treatment of Burns

Wang

Fan

Guan

et al. 2022

ACS Appl. Nano Mater.

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“…The haemolysis assays of formulations were conducted with mouse red blood cells. 30 In short, appropriate amounts of SA, CaCl 2 , LMC, normal saline and 1% Triton X-100 solution were mixed with 2% red blood cell suspension at 37 °C for 2 hours. After the samples were centrifuged at 2000 rpm at 4 °C for 15 min, the optical density (OD) of supernatants was measured with a microplate reader (Berten Instrument Co., Ltd, USA) at 540 nm.…”

Section: Methodsmentioning

confidence: 99%

The effects of Lactobacillus reuteri microcapsules on radiation-induced brain injury by regulating the gut microenvironment

Zhang,

Hu,

Song

et al. 2023

Food Funct.

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“…Hemolytic assays were performed with reference to previously reported methods. 39 Briefly, samples from different groups were incubated with 4% erythrocyte suspension for 4 h at 37 °C and 100 rpm on a thermostatic oscillator. At the end of incubation, centrifugation at 3000 rpm for 10 min was performed for photo recording.…”

Section: In Vitro Cytotoxic Experimentsmentioning

confidence: 99%

Hollow Copper Sulfide Photothermal Nanodelivery Platform Boosts Angiogenesis of Diabetic Wound by Scavenging Reactive Oxygen Species

Li,

Zhao,

Liang

et al. 2024

ACS Appl. Mater. Interfaces

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Sharply rising oxidative stress and ineffectual angiogenesis have imposed restrictions on diabetic wound healing. Here, a photothermal-responsive nanodelivery platform (HHC) was prepared by peroxidase (CAT)-loaded hollow copper sulfide dispersed in photocurable methacrylamide hyaluronan. The HHC could scavenge reactive oxygen species (ROS) and promote angiogenesis by photothermally driven CAT and Cu 2+ release. Under near-infrared light irradiation, the HHC presented safe photothermal performance (<43 °C), efficient bacteriostatic ability against E. coli and S. aureus. It could rapidly release CAT into the external environment for decomposing H 2 O 2 and oxygen generation to alleviate oxidative stress while promoting fibroblast migration and VEGF protein expression of endothelial cells by reducing intracellular ROS levels. The nanodelivery platform presented satisfactory therapeutic effects on murine diabetic wound healing by modulating tissue inflammation, promoting collagen deposition and increasing vascularization in the neodermis. This HHC provided a viable strategy for diabetic wound dressing design.

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Predatory bacterial hydrogels for topical treatment of infected wounds

Cited by 32 publications

References 61 publications

Hyaluronic Acid-Modified ZIF-8 Nano-Vehicle for Self-Adaption Release of Curcumin for the Treatment of Burns

Hyaluronic Acid-Modified ZIF-8 Nano-Vehicle for Self-Adaption Release of Curcumin for the Treatment of Burns

The effects of Lactobacillus reuteri microcapsules on radiation-induced brain injury by regulating the gut microenvironment

Hollow Copper Sulfide Photothermal Nanodelivery Platform Boosts Angiogenesis of Diabetic Wound by Scavenging Reactive Oxygen Species

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