Predictive role of neutrophil-lymphocyte and platelet-lymphocyte ratios in thyroid nodules with cytological diagnosis of "undetermined significance" and "suspicious for malignancy"

Bayır, Ömer; Karagöz, Tuğba; Öcal, Bülent; Çakal, Erman; Saylam, Güleser; Korkmaz, Mehmet

doi:10.2399/jmu.2017001003

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…In a study of the patients who underwent thyroidectomy with AUS and SM categories, a comparison was made between benign and malignant groups in terms of NLR and no significant difference was found. 20 On the other hand, some studies have shown that the other criteria are much important than the NLR as well as the pathological results in the malignancy diagnosis and surgical decision of the AUS category. In the study of Ryu et al 18 , the increase in age was found to be parallel with the increase in the risk of thyroid malignancy in the patients with Bethesda-III category by the follow-up.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Serum Neutrophil to Lymphocyte Ratio in The Results of Thyroid Fine Needle Aspiration: Can It Discriminate A Clinical Benefit for the Atypia of Undetermined Significance?

Özdemır

Çınar

Akalın

et al. 2021

Turkish Journal of Internal Medicine

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Background Thyroid biopsy results are evaluated according to The Bethesda System for reporting thyroid cytopathology worldwide. The most ambiguous result from these categories is the Bethesda-III which is defined as "atypia of undetermined significance" (AUS). Neutrophil to lymphocyte ratio (NLR) is still evaluated in thyroid disorders and malignancy. The purpose of this study was to evaluate the NLR results in Bethesda categories and whether the NLR can discriminate a clinical benefit for the AUS category. Material and MethodsIn this retrospective study, 1771 patients who had fine needle aspiration biopsy were examined. Demographic characteristics, NLR, Bethesda scores, operation rates and postoperative histopathological results were recorded. Results The categories were; Bethesda-I for 298 (16.8%), Bethesda-II for 1320 (74.5%), Bethesda-III for 60 (3.4%), Bethesda-IV for 27 (1.5%), Bethesda-V for 36 (2%), Bethesda-VI for 30 (1.7%) results respectively. The mean NLR was 2.68. There was no statistically significant difference between groups in terms of NLR (p=0.250). Overall, 226 (12.76%) patients were underwent thyroidectomy. The AUS group was found by 3.4%, operation rate was 21.66% and malignancy rate was 23.07%. There was a statistically significant difference between Bethesda scores and malignancy rates (p<0.001). There was no statistically significant difference between the postoperative results in terms of NLR (p=0.973). Conclusions The NLR does not differ according to the Bethesda categories neither the postoperative histopathological results. It is not a predictive parameter for the benign or malignant differentiation. We think that NLR cannot discriminate a clinical benefit for the surgery decision in the follow-up of the AUS category.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Serum Neutrophil to Lymphocyte Ratio in The Results of Thyroid Fine Needle Aspiration: Can It Discriminate A Clinical Benefit for the Atypia of Undetermined Significance?

Özdemır

Çınar

Akalın

et al. 2021

Turkish Journal of Internal Medicine

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“…Recent studies showed that several biomarkers, especially NLR and PLR, are associated with the inflammatory response [33,34]. However, only a few studies have evaluated the significance of the NLR in thyroid disease [35][36][37].…”

Section: Fig (1) Graphical View Of Platelet Count Mpv Values Nlr and Plr In All Phases Of Patients With Papillary Thyroid Carcinomamentioning

confidence: 99%

Comparison of Mean Platelet Volume, Platelet Count, Neutrophil/ Lymphocyte Ratio and Platelet/Lymphocyte Ratio in the Euthyroid, Overt Hypothyroid and Subclinical Hyperthyroid Phases of Papillary Thyroid Carcinoma

Kutlutürk

Gül

Sahin

et al. 2019

EMIDDT

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Introduction: Thyroid hormones are essential for the normal development, differentiation, metabolic balance and physiological function of all tissues. Mean platelet volume (MPV) indicates mean platelet size and reflects platelet production rate and stimulation. Increased platelet size has been observed in association with known cardiovascular risk factors. The neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) are known markers of the systemic inflammatory response. This study aimed to investigate the effect of thyroid hormone changes by comparing platelet count, MPV values, NLR and PLR in thyroid papillary carcinoma. Methods: Forty-nine females and nine males comprising a total of 58 patients were included in the study. Clinical and laboratory parameters of patients were recorded in the following three phases of the disease: euthyroid phase (before thyroid surgery), overt hypothyroid (OH) phase (before radioactive iodine [RAI] treatment) and subclinical hyperthyroid (SCH) phase (six months after RAI treatment). Results: The mean thyroid-stimulating hormone (TSH) values of the patients in the euthyroid, OH and SCH phases were 1.62±1.17, 76.4±37.5 and 0.09±0.07 μIU/mL, respectively. The mean MPV values of the patients in the euthyroid, OH and SCH phases were 9.45±1.33, 9.81±1.35 and 9.96±1.21 fL, respectively. MPV was significantly higher in the SCH phase than in the euthyroid phase (p=0.013). Platelet count, NLR and PLR were not statistically different between the euthyroid, OH and SCH phases. Conclusion: The results of this study demonstrated that the levels of MPV increased significantly in the SCH phase in patients with papillary thyroid carcinoma (PTC), and increased MPV values contributed to increased risk of cardiovascular complications. These findings suggest that MPV can be a valuable, practical parameter for monitoring the haemostatic condition in thyroid disorders. No significant difference was observed in platelet count, NLR and PLR in all stages of PTC.

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The Evaluation of Pretreatment and Posttreatment Platelet/Lymphocyte and Neutrophil/Lymphocyte Ratios in Patients with Hyperthyroidism

Cindoğlu

Guler

Eren

et al. 2020

Harran Üniversitesi Tıp Fakültesi Dergisi

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Öz.Amaç: Hipertiroidizm, yüksek serbest triiyodotironin (serbest T3) ve / veya serbest tiroksin düzeyleri (serbest T4) ile birlikte subnormal (genellikle saptanamayan) bir serum tirotropin (TSH) olarak tanımlanır. Endojen hipertiroidi en sık Graves hastalığı (GH) veya nodüler tiroid hastalığına bağlıdır. GH başta tiroid bezi olmak üzere, göz ve nadiren cildi tutan otoimmün bir hastalıktır. Hastalık genelde hipertiroidiye bağlı semptomlar ile tanınır. Tedavisinde anti-tiroid ilaçlar kullanılmakta olup, bu ilaçlar tiroid hormon sentezinin yanı sıra anti-inflamatuar özelliklere de sahiptir. Trombosit/lenfosit (TLO) ve nötrofil/lenfosit (NLO) oranları ise rutin kan sayımından elde edilen, ucuz ve tekrarlanabilir, sistemik inflamasyon belirteçleridir. Hipertirodide tedavi öncesi ve tedavi sonrası TLO ve NLO' nın değerlendirilmesi amaçlanmıştır. Materyal ve Metod: Çalışmaya Harran Üniversitesi Tıp Fakültesi Endokrinoloji Polikliniği'ne başvuran hastaların geçmişe yönelik kayıtları incelenerek hipertiroidi tanısı alan ve medikal tedavi başlanan hastalar alındı. Aktif enfeksiyonu ve hematolojik patolojisi olan hastalar çalışmaya dahil edilmedi. Hastaların kayıtlarından tanı anındaki ve 3-6 ay sonraki laboratuvar sonuçları değerlendirildi. Medikal tedavi öncesi ve sonrası NLO ve TLO değerlerinin karşılaştırılması planlandı. Bulgular: GH grubunda tedavi öncesi ve tedavi sonrası TSH, sT3, sT4, lökosit, nötrofil, lenfosit ve hemoglobin düzeylerinde artış vardı ve bu artış istatistiksel anlamlıydı. Bununla birlikte toksik nodüler guatr (TNG)/multınodüler guatr (MNG) grubunda TSH, sT3, sT4 değerlerinde anlamlı artış varken, lökosit, nötrofil, lenfosit ve hemoglobin düzeylerinde tedavi öncesi ve sonrası anlamlı bir fark yoktu. GH grubunda NLO tedavi sonrası öncesine göre anlamlı yüksekti ancak TLO'nda anlamlı fark gözlenmedi Sonuç: Hipertiroidi özellikle en sık nedeni olan GH hemotolojik parametrelerde çeşitli mekanizmalarla değişiklik yapabilmektedir. Antitiroid ilaçlar tiroid hormon düzeyleriyle birlikte kan sayımında da değişikliklere neden olur

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Predictive role of neutrophil-lymphocyte and platelet-lymphocyte ratios in thyroid nodules with cytological diagnosis of "undetermined significance" and "suspicious for malignancy"

Cited by 3 publications

References 18 publications

Evaluation of Serum Neutrophil to Lymphocyte Ratio in The Results of Thyroid Fine Needle Aspiration: Can It Discriminate A Clinical Benefit for the Atypia of Undetermined Significance?

Evaluation of Serum Neutrophil to Lymphocyte Ratio in The Results of Thyroid Fine Needle Aspiration: Can It Discriminate A Clinical Benefit for the Atypia of Undetermined Significance?

Comparison of Mean Platelet Volume, Platelet Count, Neutrophil/ Lymphocyte Ratio and Platelet/Lymphocyte Ratio in the Euthyroid, Overt Hypothyroid and Subclinical Hyperthyroid Phases of Papillary Thyroid Carcinoma

The Evaluation of Pretreatment and Posttreatment Platelet/Lymphocyte and Neutrophil/Lymphocyte Ratios in Patients with Hyperthyroidism

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