Pregnane Derivatives from <i>Potentilla evestita</i>

Khan, Rahmat Ullah; Siddiq, Farah; Fatima, Itrat; Yasmeen, Shazia; Karim, Aman; Malik, Abdul; Afza, Nighat; Hameed, Saira

doi:10.1177/1934578x1100600807

Cited by 3 publications

(3 citation statements)

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“…The rhizomes of P. evestita contains rich amount of tannins, i.e. 3.5% hydrolysable tannins and 15 -20% condensed tannins, pregnane derivative, 2,6b,7b-trihydroxy-4-methyl-19-norpregna-1,3,5(10)-trien-17-one, and pregnane derivative, 11a,17a,21-trihydroxypregna-4,16(22)-diene-3,20-dione, has also isolated from P. evestita (Khan, Saeed, et al 2011;Khan, Siddiq, et al 2011;Rauf et al 2013). Keeping in mind the potential ethnopharmacological uses of the plant, the isolated compound from (Figure 1) P. evestita, umbelliferone was subjected to q 2014 Taylor & Francis *Corresponding author.…”

Section: Introductionmentioning

confidence: 99%

In vivoantinociceptive and anti-inflammatory activities of umbelliferone isolated fromPotentilla evestita

Khan¹,

Khan

Pervez

et al. 2014

Natural Product Research

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This study was designed to evaluate the antinociceptive and anti-inflammatory activities of a compound, umbelliferone, isolated from the chloroform fraction of Potentilla evestita in animal models. When tested against acetic acid-induced noxious stimulus, it significantly prolonged pain threshold and provided 38.38% and 60.95% reduction in abdominal constriction at 5 and 10 mg/kg i.p., respectively. Post-umbelliferone injection evoked significant dose-dependent reduction in noxious stimulation with 33.65% and 58.89% pain attenuation at 5 and 10 mg/kg i.p., respectively, in the initial phase. In the late phase, it illustrated more dominant effect with 37.65% and 63.79% blockade of painful sensation. Similarly, it exhibited significant anti-inflammatory activity during various assessment times (1-5 h) with 46.28% and 66.13% amelioration after 4th of administration against induced oedema. In conclusion, umbelliferone possessed strong antinociceptive and anti-inflammatory activities by inhibiting both peripheral and centrally acting pain mediators.

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Section: Introductionmentioning

confidence: 99%

In vivoantinociceptive and anti-inflammatory activities of umbelliferone isolated fromPotentilla evestita

Khan¹,

Khan

Pervez

et al. 2014

Natural Product Research

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“…The rhizomes of P. evestita contains rich amount of tannins i.e . 3.5% hydrolysable tannins and 15-20% condensed tannins, pregnane derivative, 2,6 beta,7beta-trihydroxy-4-methyl-19-norpregna-1,3,5(10)-trien-17-one, and pregnane derivative, 11alpha,17alpha,21-trihydroxypregna-4,16(22)-diene-3,20-dione, have also isolated and reported from P. evestita [ 3 , 4 ]. The in - vivo antinociceptive and anti-inflammatory activities of umbelliferone isolated from the chloroform fraction of P. evestita is already reported [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Antipyretic and antinociceptive potential of extract/fractions of Potentilla evestita and its isolated compound, acacetin

Khan¹,

Khan

Ullah

et al. 2014

BMC Complement Altern Med

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BackgroundFever and pain management is a very challenging job for the clinician as the available synthetic agents are causing serious side effects. The present research article deals with the antipyretic and antinociceptive activity of extract/fractions of Potentilla evestita and acacetin isolated from the chloroform fraction of the plant.MethodsVarious chromatographic and spectroscopic techniques were used for the isolation and characterizion of compound. In-vivo yeast induced fibrile mice were used for antipyretic activity while acetic acid induced writhing and formalin tests were used for antinociceptive.ResultsThe extract/fractions of P. evestita caused marked antipyretic effect during various assessment times in which chloroform was the most prominent followed by ethyl acetate. When acacetin was injected, it produced marked effect with maximum activity of 33.28% and 55.01% at 5 and 10 mg/kg i.p respectively. When studied in acetic acid induced writhing test, the extract/fractions evoked significant antinociceptive effect in which chloroform was the most effective fraction followed by ethyl acetate. Acacetin showed significant antinociceptive effect with 44.77% and 67.03% reduction in abdominal constriction at 5 and 10 mg/kg i.p., respectively. Similarly, it evoked significant dose dependent reduction in noxious stimulation with 42.07% and 64.57% pain attenuation at 5 and 10 mg/kg i.p., respectively in initial phase. In the late phase, it illustrated more dominant effect with 46.32% and 67.29% reduction of painful sensation.ConclusionsIn conclusion, the extract/fractions of P. evestita as well as the isolated compound, acacetin showed strong antipyretic and antinociceptive activity in various animal models possibly mediated through both peripheral and central mechanism.

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“…Phytochemically, approximately 43 compounds have been isolated from P. evestita. The rhizomes of P. evestita contains rich amount of tannins that is 3.5% hydrolysable tannins and 15-20% condensed tannins, pregnane derivative, 2,6 beta,7beta-trihydroxy-4-methyl-19-norpregna-1,3,5(10)-trien-17-one, and pregnane derivative, 11alpha,17alpha,21-trihydroxypregna-4,16(22)-diene-3,20-dione, have also been isolated from P. evestita (Khan et al, 2011). In continuation of our research work on medicinal plants (Uddin et al, 2011a;2012b;Rauf et al, 2012a) herein we are reporting the isolation of three compounds using chromatographic *Corresponding author.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant studies of various solvent fractions and chemical constituents of Potentilla evestita Th. Wolf

Rauf¹

2013

Afr. J. Pharm. Pharmacol.

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In the present research work acacetin (1), chrysin (2) and umbelliferone (3) were isolated for the first time from the chloroform fraction of Potentilla evestita. The isolated compounds as well as various solvent fractions of the crude ethanolic extract were assessed for their antioxidant potentials. A significant DPPH free radical scavenging effect was observed in the methanolic and chloroform fractions. The acacetic and chrysin demonstrated significant free radical scavenging activity. Likewise compound 3 showed moderate activity as comparative. It was concluded that the therapeutic potential of this plant is due to its antioxidant potential and the antioxidant effect of P. evestita is due to the presence of these three isolated antioxidant compounds.

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Pregnane Derivatives from Potentilla evestita

Cited by 3 publications

References 2 publications

In vivoantinociceptive and anti-inflammatory activities of umbelliferone isolated fromPotentilla evestita

In vivoantinociceptive and anti-inflammatory activities of umbelliferone isolated fromPotentilla evestita

Antipyretic and antinociceptive potential of extract/fractions of Potentilla evestita and its isolated compound, acacetin

Antioxidant studies of various solvent fractions and chemical constituents of Potentilla evestita Th. Wolf

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