Pregnane Glycosides from <i>Caralluma adscendens</i> var. <i>fimbriata</i>

Kunert, Olaf; Rao, Vijayalakshmi; Babu, Gummadi Sridhar; Sujatha, Palatheeya; Sivagamy, M.; Anuradha, S.; Rao, Belvotagi Venkatrao Adavi; Kumar, Bobbala Ravi; Alex, Robert Michael; Schühly, Wolfgang; Kühnelt, Doris; Rao, Ghanakota Venkateshwara; Rao, A. S.

doi:10.1002/cbdv.200890021

Cited by 29 publications

(10 citation statements)

References 12 publications

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“…3,6 Caralluma fimbriata is an edible succulent cactus and wild medicinal plant in the family Apocynaceae, growing in dry places, used by tribal Indians to suppress hunger and known as "famine food" with no history of adverse effects, which contains pregnane glycosides. 7 This plant has been investigated for its myriad biological effects such as antihyperglycaemic and hypolipidaemic, hepatoprotective, antioxidant activity and came out with promising results. [8][9][10] In light of above reports, it is reasonable to assume that this plant could have anticancer potential.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Effect of Caralluma fimbriata Against Human Colon Cancer Cells

Ashwini¹,

Ezhilarasan²,

Anitha³

2017

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Aim: The present study was designed to examine the cytotoxic effects of ethanolic leaf extract of Caralluma fimbriata in the COLO 320 cell line. Materials and Method: The anti-proliferative effects were evaluated using the MTT assay. The COLO 320 cells were treated with different concentrations of the leaf extract of Caralluma (100 -300 µg/ml) for 24 h. The cell viability and IC 50 was calculated from the cytotoxicity. The morphology of the Caralluma treated cells, control, and positive control were observed under reverse phase inverted microscope. Result: The C. fimbriata ethanolic leaf extract showed dose dependant increase in cytotoxicity in COLO 320 human colon cancer cells. The maximum cytotoxic effect was noticed with maximum dose used in this study i.e., 300 µg with an IC 50 value of 233.87 µg. Conclusion: The present study shows that the ethanolic leaf extract of Caralluma fimbriata is capable of reducing cell proliferation by inducing cytotoxicity of COLO 320 cells.

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Section: Introductionmentioning

confidence: 99%

Cytotoxic Effect of Caralluma fimbriata Against Human Colon Cancer Cells

Ashwini¹,

Ezhilarasan²,

Anitha³

2017

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“…It is proposed that the active components within the hydroethanolic extract of Caralluma are the pregnane glycosides, which reportedly have selective serotonin reuptake inhibitor (SSRI)-like activity. [ 29 ] One proposed notion for the mechanism of hyperphagia in PWS, is namely, that reduced serotonin (5-hydroxytryptamine; 5-HT)-mediated signaling may cause decreased signaling of satiety in the brain. [ 10 19 ] Limited studies on SSRIs in PWS[ 30 31 ] have shown some clinical efficacy.…”

Section: Discussionmentioning

confidence: 99%

Caralluma fimbriata supplementation improves the appetite behavior of children and adolescents with Prader-Willi syndrome

Griggs

Mathai

2015

North Am J Med Sci

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Background:Prader-Willi syndrome (PWS) results from a deletion of the paternal genes in the region of chromosome 15q11-q13. PWS develops hyperphagia, which when left unmanaged, leads to an excessive ingestion of food. To date there is inadequate pharmacological treatment or supplementation for modification of the PWS hyperphagia and/or the associated behaviors. Therefore, the best practice is familial supervision and restriction of diet and environment.Aim:We aimed to determine if the natural supplement of Caralluma fimbriata extract (CFE) could attenuate hyperphagia or the associated appetite behaviors in children and adolescents with PWS over the 4-week pilot trial period.Materials and Methods:We conducted a placebo-controlled, double-blind, randomized crossover trial over a 10-week period to investigate the effects of CFE on hunger control, in a cohort of children and adolescents with confirmed PWS (n =15, mean age 9.27 ± 3.16 years, body weight 43.98 ± 23.99 kg). Participants from Australia and New Zealand ingested CFE or a placebo of maltodextrin/cabbage leaf over a 4-week period, with a 2-week washout before the crossover to the other treatment. Weekly comparisons in appetite behavior, severity, and drive were recorded by parents, as scaled time-point measures on a hyperphagia questionnaire validated for PWS.Results:CFE administration was found to induce a significant accumulative easing of hyperphagia (P = 0.05), with decreases evident in one-third of the participants. Furthermore due to CFE supplementation, a significant decrease (P ≤ 0.05) was recorded in the category of behavior and a decrease in hyperphagia (n = 8, P = 0.009) was observed at the highest dose 1,000 mg/day (recommended adult dose). There were no reported adverse effects at any dose.Conclusion:We demonstrate that an extract of the Indian cactus succulent Caralluma fimbriata eases hyperphagic appetite behavior within a cohort of children and adolescents (n = 15) with PWS without notable adverse effects. The outcomes of this study will have a potential positive impact on PWS management.

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“…Plusieurs especes appartenant au genre Caralluma (c. ascendens, C. dalzielli, C. penicillata, C. retrospiciens, C. russeliana, C. tuberculata), renferment des glycosides de pregnane sous forme d'esters [7][8][9][10][11][12][13][14][15]. La cytotoxicite de certains glycosides de pregnane sur differentes lignees cellulaires a ete mise en evidence [15].…”

Section: Parties Et Principes Toxiquesunclassified