Preliminary clinical studies of a biological skin equivalent in burned patients

Wassermann, D.; Schlotterer, M.; Toulon, A.; Cazalet, C; Marien, M.; Cherruau, B.; Jaffray, Patrick

doi:10.1016/0305-4179(88)90076-9

Cited by 37 publications

(8 citation statements)

References 11 publications

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“…Cellular dermis equivalents like Dermagraft TM consisting in a culture of neonatal fibroblasts onto a bioresorbable synthetic matrix are also considered [10]. Composites with both dermal and epidermal components were first introduced by Bell et al but were not fully satisfying for the treatment of severely burned patients [11]. Nevertheless, they allowed the development of new strategies and new materials such as Apligraft s [12] constituted of a fibroblast/collagen matrix on which a fine layer of stratified human epithelium was cultivated.…”

Section: Introductionmentioning

confidence: 98%

The use of physical hydrogels of chitosan for skin regeneration following third-degree burns

Boucard¹,

Viton²,

Agay³

et al. 2007

Biomaterials

343

173

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Section: Introductionmentioning

confidence: 98%

The use of physical hydrogels of chitosan for skin regeneration following third-degree burns

Boucard¹,

Viton²,

Agay³

et al. 2007

Biomaterials

343

173

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“…In another larger study using this technique in patients with fullthickness burn wounds clinical results were more disappointing. 61 In most patients treated, 60 to 90% lysis of the grafts occurred. This was thought to be related to collagenases in the wound bed.…”

Section: Cultured Autografts Combined With Cadaveric Dermal Allograftsmentioning

confidence: 97%

“…There was rapid take of grafts in three patients with good cosmetic appearance and 20% wound contraction. In another larger study using this technique in patients with full‐thickness burn wounds clinical results were more disappointing 61 . In most patients treated, 60 to 90% lysis of the grafts occurred.…”

Section: Cultured Autografts Combined With Cadaveric Dermal Allograftsmentioning

confidence: 99%

Biologic Skin Substitutes

Phillips

1993

The Journal of Dermatologic Surgery and Oncology

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“…Ambos começam com uma matriz colagênica que, depois de transplantada, se torna vascularizada e colonizada por células vindas da superfície da ferida, pois suas estruturas química e física funcionam como um esqueleto que permite a invasão celular, o que leva a se transformar numa pele substituta. Esses modelos já foram bem testados em ensaios clínicos, mas ainda existem problemas, como a rápida degradação proteolítica após o enxerto(WASSERMANN, 1988) ou a formação de cicatrizes nas margens da ferida e em áreas onde a derme artificial não foi perfeita. A ocorrência de uma prolongada instabilidade entre o enxerto e a cobertura epidérmica definitiva também foi um problema freqüentemente relatado(DESAI, 1991;RUE, 1993).Materiais à base de colágeno estão sendo investigados para reparos cirúrgicos por causa de sua baixa antigenicidade inerente e sua habilidade de se integrar com os tecidos adjacentes.…”

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Comportamento de matrizes de colágeno utilizadas no tratamento de feridas planas induzidas em pele de rato

Girardi¹

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The potentiality of the use of a collagen based matrix and of a cream prepared by the mixture of a commercial cream plus collagen (90:10 w/w) were evaluated in the healing process of rats' skin. The acellular collagen matrix and the collagen gel were obtained by an alkaline treatment of porcine serosa which does not damage the native collagen structure and removes cellular components. This study compared by macroscopy analysis and histology the skin healing repair of wounds treated with physiological solution or commercial cream (control groups) and those treated with collagen based matrix suture or commercial cream plus collagen mix. The wounds were made by removing a skin flap with 20mm 2 and have received treatment every day. The material for histology was retired on the 3 rd , 5 th , 7 th and 9 th days after surgery. Even without an accentuated difference in the healing process of both control groups and the wounds treated with de commercial cream plus collagen, its presence in the cream showed a small difference of the collagen level in the new skin what validate more investigations on this way, searching better cream:gel proportion and/or different gel concentration. The matrix demonstrated to be a very good option to help wound healing because it is easily shelf able and obtainable, it has cheap cost and it is extremely nice to handle (resistant and manipulation able), besides to follow the main requirements present in the literature citation for any biologic occlusive dressing.

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Preliminary clinical studies of a biological skin equivalent in burned patients

Cited by 37 publications

References 11 publications

The use of physical hydrogels of chitosan for skin regeneration following third-degree burns

The use of physical hydrogels of chitosan for skin regeneration following third-degree burns

Biologic Skin Substitutes

Comportamento de matrizes de colágeno utilizadas no tratamento de feridas planas induzidas em pele de rato

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