Preliminary Observations on Urinary Oestrogen Excretion in Certain Gynaecological Disorders

Brown, J. B.; Kellar, Robert J.; Matthew, G. Douglas

doi:10.1097/00006254-196002000-00028

Cited by 6 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, it is unlikely to have a similar role in women because it is well established that after hysterectomy (Beavis, Brown & Smith, 1969) and in the congenital absence of Mullerian duct structures (Fallopian tubes, uterus, vagina) the cyclic ovarian function is maintained (Brown, Kellar & Matthew, 1959;Fraser, Baird, Hobson, Michie & Hunter, 1973). This paper has shown clearly that there is a cyclic variation in the levels…”

Section: Discussionmentioning

confidence: 77%

Levels of prostaglandins in human endometrium during the normal menstrual cycle

Downie¹,

Poyser²,

Wunderlich³

1974

The Journal of Physiology

213

View full text Add to dashboard Cite

SUMMARYThe levels of prostaglandins in the human endometrium throughout the normal menstrual cycle were measured by bioassay. The identity of prostaglandin F. and prostaglandin E2 in endometrial tissue extracts was established by combined gas chromatography/mass spectrometry.The levels of prostaglandin F2,, and prostaglandin E2 are low during the proliferative phase of the cycle (10-25 ng/100 mg tissue). Prostaglandin F2. rises significantly during the luteal phase to levels of 65-75 ng/100 mg of tissue. Prostaglandin E2 levels are similar to prostaglandin Fu levels in the proliferative phase but remain lower during the luteal phase. The prostaglandin E2 level is highest at menstruation (52 ng/100 mg tissue). The implications of these findings are discussed in relation to the menstrual process and to the steroid hormonal changes during the cycle.

show abstract

Section: Discussionmentioning

confidence: 77%

Levels of prostaglandins in human endometrium during the normal menstrual cycle

Downie¹,

Poyser²,

Wunderlich³

1974

The Journal of Physiology

213

View full text Add to dashboard Cite

show abstract

“…For urine hormone levels, it was difficult to compare and combine data from different studies. This is true, in part, because some used overnight data corrected for creatinine (34) and others used 24 h urine collections (35)(36)(37) without creatinine correction. Following the suggestion of Metcalf and MacKenzie (38), this review has analyzed the number of days in a cycle in which the total urinary estrogen excretion exceeded the normal midcycle peak (MCP) level in that assay system.…”

mentioning

confidence: 99%

Perimenopause: The Complex Endocrinology of the Menopausal Transition

1998

View full text Add to dashboard Cite

“…26 The endometrium often breaks down unevenly, even when circulating estrogen concentrations are high or rising, with scattered red patches as seen in hysteroscopy, corresponding to thrombotic foci of necrotic disintegration, adjacent to the abnormally proliferated endometrium. 27,28 An increased production of endometrial nitric oxide (endothelium derived relaxing factor) in response to excessive and unopposed estrogen has been postulated as another mechanism leading to excessive blood loss in anovulatory menstruation. 29 Although anovulation is the most common finding associated with DUB, a number of ovulatory patients have intermenstrual bleeding.…”

Section: Discussionmentioning

confidence: 99%