Role of serum copper and ceruloplasmin level in patients with dysfunctional uterine bleeding

Khandhadiya, Ketki; Chianeh, Yousef Rezaei; Rao, Pragna

doi:10.5455/2320-1770.ijrcog20140608

Cited by 4 publications

(3 citation statements)

References 21 publications

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“…16,18 It has been shown that growth of the blood vessels in some circumstances has some unknown etiology, subsequently it is being attributed to involvement of copper. 19 Presently it has been confirmed that copper can induce the neovascularisation.…”

Section: Copper and Ceruloplasminmentioning

confidence: 99%

See 1 more Smart Citation

Angiogenic factors in relation to embryo implantation

Bagheri

Chianeh

Kumar

et al. 2014

Int J Reprod Contracept Obstet Gynecol

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Section: Copper and Ceruloplasminmentioning

confidence: 99%

“…Copper can stimulate, synthesis and proliferate many growth factors 16,17 and it has a common pathway for utilization of hypoxia to regulate VEGF-A expression. 16,18 It has been shown that growth of the blood vessels in some circumstances has some unknown etiology, subsequently it is being attributed to involvement of copper.…”

Section: Copper and Ceruloplasminmentioning

confidence: 99%

Angiogenic factors in relation to embryo implantation

Bagheri

Chianeh

Kumar

et al. 2014

Int J Reprod Contracept Obstet Gynecol

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“…High levels of ceruloplasmin expression have been demonstrated in various cancers and non-cancerous condition such as thyroid carcinoma 19 ,melanoma 20 and patient with dysfunctional uterine bleeding 21,22 . Dysregulation of copper transport due to ceruloplasmin expression in tumors has been studied by suppressing copper with tetrathiomolybdate in head and neck tumors in clinical trials.This study has designed to identify a possible role and correlations between serum ceruloplasmin level and CA125 in ovarian cancer that indicate the role of ceruloplasmin in the pathophysiology of ovarian cancer.…”

Section: Introductionmentioning

confidence: 99%

Over Kanserli Hastalarda CA-125 ve Seruloplazmin Düzeyleri

Hegde¹,

Chianeh²,

Shetty³

et al. 2015

Cukurova Medical Journal

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Purpose: The initial stage of proliferation of epithelial ovarian carcinoma (EOCa) is usually asymptomatic. Due to the lack of sensitive and reliable markers in majority of patients the disease is widespread at the time of diagnosis. The reliable serum biomarkers currently accepted is CA125 but there is limitation in case of sensitivity of CA125 as it is detectable only in 50% of patients in stage I and 80% of patients with advanced stage. We have investigated a correlation between serum CA125 and ceruloplasmin (as a marker of angiogenesis) in ovarian cancer in pre-treatment and post-treatment patients, compared with controls and found to be a significant marker for diagnosis. Material and Methods: A study was done in age group between 18-45 years diagnosed with ovarian cancer. (cases: n=50, controls: n=50). Cancer was diagnosed based on biopsy and histopathological examination. Serum Ceruloplasmin and CA 125 were estimated in pre-treatment and post-treatment patients and statistically significant decrease of these biomarkers observed in post treatment when compared with pre treatment patients. Result: We found that serum CA 125 to ceruloplasmin ratio was moderately increased in pre-treatment ovarian cancer patient. The serum ceruloplasmin (p<0.0001) level was significantly increased in ovarian cancer patients as compared to controls. Conclusion: Serum ceruloplasmin as well CA-125 level decline after treatment, and have been associated with efficacy and safety of novel therapeutic strategy to improve diagnosis and treatment for cancer. Key words: Epithelial ovarian carcinoma (EOCa), Ceruloplasmin, Carbohydrate antigen 125 (CA-125). ÖZETAmaç: Epitelial ovarian karsinomunda proliferasyonunun başlangıç aşaması genellikle asemptomatiktir. Hastaların büyük kısmında hassas ve güvenilir belirteçlerin eksikliği nedeni ile hastalık teşhis aşamasında artık yayılmış bulunmaktadır. Güvenilir olarak kabul edilen serum belirteci CA-125'tir ancak evre I hastalarının sadece %50'sinde ve ilerlemiş evre hastaların %80'ninde saptanabilmesinden dolayı, CA-125'in hassasiyeti konusunda bir sınırlama mevcuttur. Bu çalışmada, tedavi öncesi ve tedavi sonrası over kanserli hastalarda CA-125 ve seruloplazmin'in (anjiyogenez belirteci) serum seviyeleri arasındaki korelason araştırılmış, kontroller ile karşılaştırılmış ve teşhis için anlamlı bir belirteç olduğu bulunmuştur. Materyal ve Metod: Çalışma 18-45 yaş arası over kanseri teşhisi alan hastalar ile yapılmıştır (vaka n=50, kontrol n=50). Kanser teşhisi, biyopsi ve histopatolojik değerlendirme sonucu konulmuştur. Tedavi öncesi ve tedavi sonrası serum seruloplazmin ve CA-125 seviyeleri değerlendirilmiş ve tedavi öncesi ile karşılaştırıldığında, bu belirteçlerin tedavi sonrası hastalarda anlamlı derecede düştüğü gözlenmiştir. Araştırma Makalesi / Research Article

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Collagen metabolism and antioxidant status in the paw tissue of type II collagen-induced arthritic rats—protective role of alginic acid isolated from Sargassum wightii

Sarithakumari

Kurup

2014

Comp Clin Pathol

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Role of serum copper and ceruloplasmin level in patients with dysfunctional uterine bleeding

Cited by 4 publications

References 21 publications

Angiogenic factors in relation to embryo implantation

Angiogenic factors in relation to embryo implantation

Over Kanserli Hastalarda CA-125 ve Seruloplazmin Düzeyleri

Collagen metabolism and antioxidant status in the paw tissue of type II collagen-induced arthritic rats—protective role of alginic acid isolated from Sargassum wightii

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