Preoperative MRA Flow Quantification in CEA Patients

Rutgers, D. R.; Blankensteijn, Jan D.; Grond, Jeroen van der

doi:10.1161/01.str.31.12.3021

Cited by 67 publications

(9 citation statements)

References 51 publications

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“…Compared with other studies, the main contribution of this paper is that the anatomical variations in the posterior circulation were investigated and we have considered more variations. The major concern of this study are blood flow rates of various cerebral arteries, however, there is not enough data based on all of the cases in this study, therefore, we just comparing the distribution of flow of afferent and efferent arteries with published PC-MRI measurements [ 27 , 28 , 31 ] for some special models, such as the NT and fuFTP models. In the case of NT model with no-stenosis, the VFR of unilateral ICA, MCA and ACA with this measurement are about 210-280 ml/min, 130-155 ml/min and 75-90 ml/min, respectively.…”

Section: Discussionmentioning

confidence: 99%

A 3D numerical study of the collateral capacity of the circle of Willis with anatomical variation in the posterior circulation

Ren

Chen

2015

BioMed Eng OnLine

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Section: Discussionmentioning

confidence: 99%

A 3D numerical study of the collateral capacity of the circle of Willis with anatomical variation in the posterior circulation

Ren

Chen

2015

BioMed Eng OnLine

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“…Knowledge of the circle of Willis is of importance, since the prevalence of adequate collateral supply via the circle of Willis is associated with a reduced risk of recurrent stroke [2], a smaller infarct size [11], a normal response to CO 2 reactivity tests [12] and a reduced occurrence of ischemia during clamping of the carotid artery [13]. Likewise, a significant difference in the prevalence of normal circles between patients with and without cerebral infarction has been shown at autopsy (22 vs. 52%) [6].…”

Section: Discussionmentioning

confidence: 99%

Anatomic Variations in the Circle of Willis in Patients with Symptomatic Carotid Artery Stenosis Assessed with Multidetector Row CT Angiography

et al. 2006

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Purpose: To assess the presence of anterior and posterior collateral pathways in the circle of Willis in patients with symptomatic carotid artery stenosis (SCAS) and to compare this to patients without carotid artery stenosis. Materials and Methods: Multislice CT angiography was performed in 91 patients and 91 control subjects. Using consensus reading, 2 observers evaluated the presence and diameter of the anterior communicating artery (AcomA), the A1 segments of the anterior cerebral arteries, the posterior communicating arteries (PcomA) and the P1 segments of the posterior cerebral arteries. Anterior or posterior pathways were assumed to be present if the diameter of continuous arterial segments was >1 mm; both A1 segments and AcomA anterior, and ipsilateral P1 segment and PcomA posterior. Comparison between patients and controls was performed using the χ² test. Results: In the patients we found significantly more hypoplastic (<1 mm) or invisible A1 segments (16 and 14 vs. 4 and 1, respectively, p < 0.01). The AcomA was invisible in 4 patients versus 1 control. An isolated compromised anterior pathway and a combined compromised anterior and posterior pathway occurred more frequently in the patients as compared to the controls; 9 versus 1% (p < 0.01) and 26 versus 4% (p < 0.01). Conclusion: A compromised anterior collateral pathway, usually combined with a compromised posterior pathway, occurs more frequently in patients with SCAS as compared to controls, which suggests a relation between symptomatic carotid stenosis and an incomplete circle of Willis.

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“…Determination of total cerebral (tCBF) blood flow to the brain, by measuring flow in the internal carotid arteries (ICA) and posterior circulation has been applied in patients with obstructive disease of the ICA or posterior circulation[1], [2], arteriovenous malformations[3], acute neurotrauma[4], cerebral ischemia[5], and the evaluation of vascular interventions such as bypass surgery[6] or carotid endarterectomy[7]. In these studies tCBF was expressed in mL/min, regardless of the volume of the supplied brain.…”

Section: Introductionmentioning

confidence: 99%

Associations between Total Cerebral Blood Flow and Age Related Changes of the Brain

Grond

Dam

et al. 2010

PLoS ONE

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Background and PurposeAlthough total cerebral blood flow (tCBF) is known to be related to age, less is known regarding the associations between tCBF and the morphologic changes of the brain accompanying cerebral aging. The purpose of this study was to investigate whether total cerebral blood flow (tCBF) is related to white matter hyperintensity (WMH) volume and/or cerebral atrophy. Furthermore, we investigate whether tCBF should be expressed in mL/min, as was done in all previous MR studies, or in mL/100 mL/min, which yielded good results in precious SPECT, PET and perfusion MRI studies investigating regional cerebral blood flow.Materials and MethodsPatients were included from the nested MRI sub-study of the PROSPER study. Dual fast spin echo and FLAIR images were obtained in all patients. In addition, single slice phase contrast MR angiography was used for flow measurements in the internal carotids and vertebral arteries. tCBF was expressed in both mL/min and mL/100 mL/min.ResultsWe found a significant correlation between tCBF in mL/min and both age (r = −.124; p = p≤.001) and parenchymal volume (r = 0.430; p≤.001). We found no association between tCBF in mL/min and %-atrophy (r = −.077; p = .103) or total WMH volume (r = −.069; p = .148). When tCBF was expressed in mL/100 mL/min the correlation between tCBF and age was no longer found (r = −.001; p = .985). Multivariate regression analyses corrected for age showed a significant correlation between tCBF in mL/100 mL/min and WMH volume (r = −.106; p = .044). No significant association between tCBF in mL/100 mL/min and %-atrophy was found.ConclusionFrom this study we conclude that, when evaluating tCBF alterations due to various pathologies, tCBF should in mL/100 mL/min instead of mL/min. Furthermore, changes or differences in WMH volume should be accounted for.

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Preoperative MRA Flow Quantification in CEA Patients

Cited by 67 publications

References 51 publications

A 3D numerical study of the collateral capacity of the circle of Willis with anatomical variation in the posterior circulation

A 3D numerical study of the collateral capacity of the circle of Willis with anatomical variation in the posterior circulation

Anatomic Variations in the Circle of Willis in Patients with Symptomatic Carotid Artery Stenosis Assessed with Multidetector Row CT Angiography

Associations between Total Cerebral Blood Flow and Age Related Changes of the Brain

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