Preparation and anti-influenza A virus activity of κ-carrageenan oligosaccharide and its sulphated derivatives

Wang, Wei; Zhang, Pan; Yu, Guangli; Li, Chunxia; Hao, Cui; Qi, Xin; Zhang, Lijuan; Guan, Huashi

doi:10.1016/j.foodchem.2012.01.108

Cited by 98 publications

(72 citation statements)

References 30 publications

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“…Twelve signals corresponding to the disaccharide repeating unit of CAO were observed in Figure 3B. The signal at 91.22 ppm was assigned to the C-1 of 4-1inked residue D, and the signal of at 103.62 ppm was related to the C-1 of 3-1inked residue G. The region from 60 ppm to 90 ppm was that of the other signals of CAO, as reported previously [23,24,25]. The structure of CAO was determined to be the repeating disaccharide as shown in the inset of Figure 3A.…”

Section: Resultssupporting

confidence: 80%

Green Synthesis of Gold Nanoparticles Using Carrageenan Oligosaccharide and Their In Vitro Antitumor Activity

et al. 2018

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Gold nanoparticles (AuNPs) have been widely used in catalysis, photothermal therapy, and targeted drug delivery. Carrageenan oligosaccharide (CAO) derived from marine red algae was used as a reducing and capping agent to obtain AuNPs by an eco-friendly, efficient, and simple synthetic route for the first time. The synthetic conditions of AuNPs were optimized by response surface methodology (RSM), and the CAO-AuNPs obtained were demonstrated to be ellipsoidal, stable and crystalline by means of transmission electron microscopy (TEM), scanning electron microscopy (SEM) and X-ray diffraction (XRD). The CAO-AuNPs showed localized surface plasmon resonance (LSPR) oscillation at about 530 nm with a mean diameter of 35 ± 8 nm. The zeta potential of CAO-AuNPs was around −20 mV, which was related to the negatively charged CAO around AuNPs. The CAO-AuNPs exhibited significant cytotoxic activities to HCT-116 and MDA-MB-231 cells, which could be a promising nanomaterial for drug delivery.

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Section: Resultssupporting

confidence: 80%

Green Synthesis of Gold Nanoparticles Using Carrageenan Oligosaccharide and Their In Vitro Antitumor Activity

et al. 2018

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“…(3) and (4) leads to Eqs. (5), (6), and (7) for zero order (kz), first order (kf), and second order (ks) reaction, respectively.…”

Section: (4)mentioning

confidence: 99%

“…The high-molecular-weight (HMW) κ-carrageenan has limited applications as it is insoluble in water and it forms a viscous solution. By changing HMW -carrageenan into low molecular weight (LMW), -carrageenan increases the bioavailability and its potential applications for biomedical applications [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

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Kinetics of Oxidative Depolymerization of κ-carrageenan by Ozone

Prasetyaningrum

Ratnawati

Jos

2017

Bull. Chem. React. Eng. Catal.

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Depolymerization kinetics of κ-carrageenan by ozone treatment has been studied at various pHs and times. The purified κ-carrageenan with the initial molecular weight of 271 kDa was dispersed in water to form (1 % w/v) solution. Ozone with 80±2 ppm concentration and constant flow rate of 3 L.min -1 was bubbled into the κ-carrageenan solution. The experiments were conducted at pH of 3, 7, and 10 at different times (5, 10, 15, and 20 minutes) of ozonation. The viscosity of the solution was measured using Ubbelohde capillary viscometer, which was then used to find the number-average molecular weight by Mark-Houwink equation. The number-average molecular weight data was treated using zero, first, and the second-order reaction kinetics model, to obtain the kinetics of κ-carrageenan depolymerization. The depolymerization is assumed to occur by random scission. The results show that the kinetics rate constant of κ-carrageenan depolymerization is higher at lower pHs. The second-order model is more suitable for describing the kinetics of depolymerization of κ-carrageenan by ozonation process. The rate constants for the second-order kinetics model are 5.45×10 -4 min -1 , 1.27×10 -4 min -1 , and 7.21×10 -5 min -1 for pH 3, 7, and 10, respectively. The actual values of reaction order under acid and alkali conditions are ranging from 1.88 to 1.90.

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“…Large molecular size of κ-carrageenan have limited applications as it is insoluble in water and it forms viscous solution. Converting the High Molecular Weight Fraction of carrageenan (HMWF) into Low Molecular Weight of carrageenan (LMWF) will construct the bioavailability and enlarge the potential uses of carrageenan in pharmaceutical and biomedical [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Chemical and Spectral Characterization of The Ozonation Products of κ-Carrageenan

et al. 2018

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Abstract. Kappa (κ-) carrageenan oligomers are known to have several biological activities. Recent progress in the development of modified κ-carrageenan has resulted low molecular of κ-carrageenan. Ozone is a powerful oxidant and considered for depolymerization of κ-carrageenan. However, few studies have investigated the changes in κ-carrageenan properties associated with ozone treatment. This study would investigate on the changes in chemical structure after ozonation process. The experiments were carried out in a glass reactor equipped with an ozone bubble diffuser. Ozone with concentration of 80 ± 2 was bubbled into the solution. The ozone treatment was conducted at different times, i.e., 0 (control), 5, 10, 15, and 20 minutes. The experiments were conducted at pH 7 and constant stirring speed (200 rpm). Ozone-treated κ-carrageenan was dried at 60 o C for 24 h in a forced air oven. The chemical and spectral analyses of κ-carrageenan after ozonation process were carried out using UV-Vis and FT-IR spectroscopy. These changes are seen in the UV spectra as a high intensity of absorbance peak at 290 nm. It is shows that ozonation of κ-carrageenan leads to some chemical changes such as the formation of carbonyl, carboxyl or double bonds.The FT-IR spectra reveals that the chemical structure of degraded κ-carrageenan, in term of sulfate content, is only slightly affected by the ozone treatment.

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Preparation and anti-influenza A virus activity of κ-carrageenan oligosaccharide and its sulphated derivatives

Cited by 98 publications

References 30 publications

Green Synthesis of Gold Nanoparticles Using Carrageenan Oligosaccharide and Their In Vitro Antitumor Activity

Green Synthesis of Gold Nanoparticles Using Carrageenan Oligosaccharide and Their In Vitro Antitumor Activity

Kinetics of Oxidative Depolymerization of κ-carrageenan by Ozone

Chemical and Spectral Characterization of The Ozonation Products of κ-Carrageenan

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