Preparation and characterization of electrospun antimicrobial fibrous membranes based on polyhydroxybutyrate (PHB)

Fan, Xiaoyan; Jiang, Qianyuan; Sun, Zhe; Li, Gai; Ren, Xiaofeng; Liang, Jie; Huang, Tung‐Shi

doi:10.1007/s12221-015-5108-1

Cited by 39 publications

(21 citation statements)

References 42 publications

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“…A steep reduction of the viable E. coli was detected for PHB/PEO with 1% chlorhexidine in a very short time, but PHB/PEO showed an increasing amount of E. coli at 24 h . Poly[5,5‐dimethyl‐3‐(3′‐triethoxysilylpropyl)hydantoin]/PHB fibrous membranes after chlorine bleach treatment had excellent antimicrobial activities which could inactivate 92% S. aureus and 85% E. coli within 30 min, respectively . Electrospun Pluronic F‐108/PHB fiber meshes were fibroblasts‐compatible wound dressing scaffolds, with a higher blood clotting rate and tensile moduli than PHB.…”

Section: Preparation Of Antimicrobial Surfacementioning

confidence: 99%

Surface Modification of Polyhydroxyalkanoates toward Enhancing Cell Compatibility and Antibacterial Activity

Liu

Zhang

et al. 2017

Macro Materials & Eng

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Biomaterials for in vivo application should induce positive interaction with various histocytes and inhibit bacteria inflection as well. Cells and/or bacteria response to the extracellular environment is therefore the basic principle to design the biomaterials surface in order to induce the specific biomaterial–biological interaction. Polyhydroxyalkanoate (PHAs) are of growing interests because of their natural origin, biodegradability, biocompatibility, and thermoplasticity; however, quite inert and intrinsic hydrophobic characteristics have hindered their extensive usage in medical applications. Surface modification of PHAs tailors the chemistry, wettability, and topography without altering the bulk properties, and introduces specific proteins/peptides and/or antibacterial agents to mediate cell–matrix interactions. This review describes the recent developments on the surface modification of PHAs to construct cell compatible and antibacterial surfaces.

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Section: Preparation Of Antimicrobial Surfacementioning

confidence: 99%

Surface Modification of Polyhydroxyalkanoates toward Enhancing Cell Compatibility and Antibacterial Activity

Liu

Zhang

et al. 2017

Macro Materials & Eng

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“…can also be considered as environmentally friendly as they can undergo disintegration in compost soil thus giving solution to waste accumulation . Among the wide variety of environmentally friendly polymers, poly(3‐hydroxybutyrate) (P3HB) is one of the most promising ones because of its excellent balanced properties such as disintegration in compost soil, biocompatibility, UV light resistance, mechanical features similar to polypropylene, etc . All these features make P3HB an excellent candidate for biomedicine applications, or disposable products from the packaging industry .…”

Section: Introductionmentioning

confidence: 99%

Improvement of Mechanical Ductile Properties of Poly(3-hydroxybutyrate) by Using Vegetable Oil Derivatives

Garcia‐Garcia

Fenollar

Fombuena

et al. 2016

Macromol. Mater. Eng.

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Poly(3‐hydroxybutyrate), P3HB is a thermoplastic polyester synthesized from bacterial fermentation with potential uses in packaging due to its biodegradability. Nevertheless, P3HB is a fragile material and its processing temperature window is very narrow which restricts its use. This study explores the potential of vegetable oil‐derived plasticizers, i.e., maleinized linseed oil (MLO) and an epoxidized fatty acid ester (EFAE) in the 5–20 phr range as environmentally friendly solutions for P3HB industrial formulations with improved toughness. The results show that optimum balance between ductile properties is achieved with low plasticizer content (5 phr) for both plasticizer types. Elongation at break and the impact resistance are increased by 28 and 71% respectively after addition of 5 phr MLO. With regard to EFAE, the elongation at break is improved by 40% and the impact resistance is increased to twice the value of P3HB. Another effect that both plasticizers provide is the thermal stabilization with a delay in the onset degradation temperature.

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“…There were 2 degradation steps that occurred in the TGA curves for all samples. In PHB/PBAT, the first degradation was PHB, and its weight loss was from 250°C to 300°C . The PBAT was the second degradation, and the temperature for its weight loss was from 400°C to 472°C .…”

Section: Resultsmentioning

confidence: 99%

“…N ‐Halamine precursors could be attached onto surfaces of fibers and polymers by grafting techniques or other coating methods to prepare antibacterial materials . Besides, electrospun N ‐halamine membranes have been reported for its favorable property …”

Section: Introductionmentioning

confidence: 99%

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Preparation and characterization of PHB/PBAT–based biodegradable antibacterial hydrophobic nanofibrous membranes

Lin

Fan

et al. 2017

Polymers for Advanced Techs

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In this study, polyhydroxybutyrate/poly(butyleneadipate-co-terephthalate) (PHB/PBAT) nanofibrous membranes were produced by electrospinning the blends of biodegradable PHB and PBAT. The antibacterial hydrophobic nanofiber membranes were obtained by grafting 1-allylhydantoin and perfluorooctyl acrylate onto the PHB/PBAT membranes. The prepared nanofibrous membranes were chlorinated with chlorine bleach and characterized by scanning electron microscopy, Fourier transform infrared, and thermogravimetric analysis. The chlorinated nanofibrous membranes exhibited efficient antimicrobial activity against Escherichia coli O157:H7 (ATCC 43895) and Staphylococcus aureus (ATCC 6538) with 6.08 and 5.78 log reduction, respectively. The contact angle of this antibacterial membrane was 123.1°± 1.9°. The treated membranes showed good stability and durability towards UV-A light exposure and storage. To effectively block the entry of water and moisture and slow down food spoilage, food packaging materials need to be hydrophobic.Hydrophobic agents including wax, aluminum soap, zirconium soap, | ElectrospinningEight percent (wt) of PHB and PBAT (PHB/PBAT, 1:1, w/w) were dissolved in a mixture of CHCl 3 and DMF (CHCl 3 /DMF, 10:1, w/w).Electrospinning was performed at 20 kV with a flow rate of 1.5 mL·h −1 at ambient temperature. The distance from tip to collector was 15 cm. The electrospun fibrous membranes were collected on a rotating drum covered with an aluminum foil at a speed of 50 rpm. | Grafting AH and PFAThe mechanism scheme of AH and PFA grafting on PHB/PBAT surfaces is shown in Scheme 1. Initially, AH (1, 2, 3, 4, 5, 7, and 9 wt%) and AIBN (10 wt% of AH) were dissolved in ethanol solution in an ultrasonic bath for 20 minutes. Ethanol solution was at a bath ratio of 50:1 on the weight of fibrous membranes. Then, a certain amount of PHB/PBAT fibrous membranes was immersed in the above solution in a water bath at 75°C for 3 hours. Subsequently, fibrous membrane was extracted in ethanol for 24 hours using a Soxhlet extractor.Perfluorooctyl acrylate (3, 5, 7, 9, 11, and 13 wt%), AIBN (10 wt% of PFA), and OP-10 (2 wt% of PFA) were dissolved in ethanol solution by ultrasonic vibration for 20 minutes at room temperature. The PHB/PBAT fibrous membranes were added into the solution in a water bath at 75°C for 3 hours. Subsequently, fibrous membrane was extracted in ethanol for 24 hours using a Soxhlet extractor. | Chlorination and titrationThe PHB/PBAT-AH/PFA fibrous membranes were immersed in a 0.05% of NaOCl solution, pH 7, at ambient temperature for 1 hour to become an antimicrobial material. Then, the chlorinated fibrous membranes were washed thoroughly with deionized water and dried at 45°C for 1 hour to remove the unbound chlorine. The loaded active chlorine content on the membranes was measured by the modified iodometric/thiosulfate titration method. The chlorine weight percent of the membranes was calculated according to the equation below:where Cl + (%) is the weight percent of active chlorine on the sample; N and V are...

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Preparation and characterization of electrospun antimicrobial fibrous membranes based on polyhydroxybutyrate (PHB)

Cited by 39 publications

References 42 publications

Surface Modification of Polyhydroxyalkanoates toward Enhancing Cell Compatibility and Antibacterial Activity

Surface Modification of Polyhydroxyalkanoates toward Enhancing Cell Compatibility and Antibacterial Activity

Improvement of Mechanical Ductile Properties of Poly(3-hydroxybutyrate) by Using Vegetable Oil Derivatives

Preparation and characterization of PHB/PBAT–based biodegradable antibacterial hydrophobic nanofibrous membranes

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