Preparation and Characterization of Insulin-Loaded Acrylic Hydrogels Containing Absorption Enhancers.

Uchida, Takahiro; Toida, Yuka; Sakakibara, Sadako; Miyanaga, Yohko; Tanaka, Hiromi; Nishikata, Mayumi; Tazuya, Keiko; Yasuda, Noriko; Matsuyama, Kenji

doi:10.1248/cpb.49.1261

Cited by 18 publications

(5 citation statements)

References 13 publications

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“…Increasing Capmul ® MCM C8 concentration from 0 to 10% w/w had no significant effect on the drug release profile, while increasing it to 20% w/w (F3) resulted in a significant higher drug release. This improved release can be explained by the formation of micelles by Capmul ® MCM C8 within the polymeric network [32][33][34]. This result was also confirmed by the release rate constants obtained in table 2.…”

Section: In Vitro Drug Release Studiessupporting

confidence: 61%

Drug Release Control and Enhancement Using Carriers With Different Concentrations of Capmul® MCM C8

Bayan

2021

Int J App Pharm

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Objective: The main aim of this study was to design a drug carrier capable to control and enhance the release of poorly water soluble drugs. Methods: Three polymeric formulations, based on poly (2-hydroxyethyl methacrylate) and loaded with different Capmul® MCM C8 concentrations (0, 10 and 20 % w/w), were prepared. Felodipine, which is a poorly soluble substance, was selected as a model drug. The effect of Capmul® MCM C8 on swelling behavior and in vitro release profile of the prepared polymer was investigated in PBS. Results: The swelling profiles of allformulationswere statistically similar, which indicated the non-significant effect of added Capmul® MCM C8 on polymer's swelling behavior. All formulations showed a delayed drug release. Formulation-F3, which is loaded with 20% w/wCapmul® MCM C8 displayed a significant higher release compared to the other formulations. Conclusion: Capmul® MCM products, which are widely used in food industries, can be used to improve the oral delivery of poorly soluble substances. The optimized formulation exhibited the ability to control and enhance the release of the model drug.

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Section: In Vitro Drug Release Studiessupporting

confidence: 61%

Drug Release Control and Enhancement Using Carriers With Different Concentrations of Capmul® MCM C8

Bayan

2021

Int J App Pharm

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“…Poloxamer and HPMC-based composite hydrogels have been studied for the delivery of quinine by rectal route in children [242] . Insulin-loaded acrylate hydrogels have shown capability to decrease serum glucose concentrations when administered rectally [243] . Drug loaded microspheres have been incorporated within the hydrogel-based rectal suppositories [244] .…”

Section: Rectal Deliverymentioning

confidence: 99%

Hydrogel-Based Controlled Release Formulations: Designing Considerations, Characterization Techniques and Applications

Pal

Singh

Anis

et al. 2013

Polymer-Plastics Technology and Engineering

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Hydrogels have evolved over the last decade as materials of choice in varied biomedical applications. This is associated with the inherent biocompatible nature of the hydrogels. The modulation of the properties of the hydrogels is easily possible due to the availability of polymers of varied chemistry and physical properties. This review discusses the pharmaceutical aspects of the controlled release of bioactive agents from hydrogel-based formulations.

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“…The polymeric nanocarriers have been used to enhance solubility, bioavailability, and prolonged circulation times of insulin 108. The rectal form of insulin composed of acrylic hydrogels containing absorption enhancers was applied in in vitro and in vivo environment 109…”

Section: Hydrogels For Peptide Hormone Deliverymentioning

confidence: 99%

<p>Hydrogels For Peptide Hormones Delivery: Therapeutic And Tissue Engineering Applications</p>

Doostmohammadi¹,

Ameri²,

Mohammadinejad³

et al. 2019

DDDT

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Peptides are the most abundant biological compounds in the cells that act as enzymes, hormones, structural element, and antibodies. Mostly, peptides have problems to move across the cells because of their size and poor cellular penetration. Therefore, a carrier that could transfer peptides into cells is ideal and would be effective for disease treatment. Until now, plenty of polymers, e.g., polysaccharides, polypeptides, and lipids were used in drug delivery. Hydrogels made from polysaccharides showed significant development in targeted delivery of peptide hormones because of their natural characteristics such as networks, pore sizes, sustainability, and response to external stimuli. The main aim of the present review was therefore, to gather the important usages of the hydrogels as a carrier in peptide hormone delivery and their application in tissue engineering and regenerative medicine.

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Preparation and Characterization of Insulin-Loaded Acrylic Hydrogels Containing Absorption Enhancers.

Cited by 18 publications

References 13 publications

Drug Release Control and Enhancement Using Carriers With Different Concentrations of Capmul® MCM C8

Drug Release Control and Enhancement Using Carriers With Different Concentrations of Capmul® MCM C8

Hydrogel-Based Controlled Release Formulations: Designing Considerations, Characterization Techniques and Applications

<p>Hydrogels For Peptide Hormones Delivery: Therapeutic And Tissue Engineering Applications</p>

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