Preparation and Characterization of pH Sensitive Semi-interpenetrating Network Hydrogel Based on Methacrylic Acid, Bovine Serum Albumin (BSA), and PEG

Dynamics of Pseudomonas aeruginosa association with anionic hydrogel surfaces in the presence of aqueous divalent-cation salts

“…2b illustrates that when p-MAA beads initially saturated with PBS (pH = 7.4) were exposed to 100-mM NaCl in PBS (pH = 7.4), they shrank by about 10%. These two results strongly suggest that appended carboxylic side groups in the p-MAA polymeric network are ionized at pH = 7.4 in agreement with the expected p K a of less than 7 [40,41]. Experiments performed on p-MAA and p-AA membranes showed similar results (data not shown).…”

Biodegradable poly(ɛ-caprolactone)–poly(ethylene glycol) copolymers as drug delivery system

“…In order to increase bioavailability of drugs by oral route, pH-sensitive hydrogels are used as the drug delivery system (Peppas and Klier, 1991;Markland et al, 1999;Torres-Lugo and Peppas, 1999;Ichikawa and Peppas, 2003;Kim et al, 2003a;Chao et al, 2006Chao et al, , 2008Chen et al, 2008b;Wang et al, 2009). The pH-sensitive hydrogels contain pendant acidic or alkaline groups which can accept or release protons in response to changes of environmental pH (known as polyanionic and polycationic hydrogel, respectively).…”

“…In past decades, the stimuli-sensitive copolymer hydrogel has gained increasing attention owing to their biodegradability, biocompatibility, and smart responsibility to the environmental stimulus, including chemical substances and changes in temperature, pH, light, pressure, electric field, etc. Among them, especially, the thermosensitive physical crosslinked hydrogels and pH-sensitive hydrogels, consisted of hydrophobic PCL (A) blocks and hydrophilic PEG (B) blocks, have been extensively studied because of their potential biomedical applications in advanced drug delivery system, including controlled drug delivery, cell encapsulation and tissue repair (Jeong et al, 1997;Markland et al, 1999;Torres-Lugo and Peppas, 1999;Lee et al, 2001;Jeong et al, 2002;Kissel et al, 2002;Ichikawa and Peppas, 2003;Kim et al, 2003a;Li et al, 2003a,b;Song et al, 2004;Chao et al, 2006Chao et al, , 2008Liu et al, 2007a,b;Chen et al, 2008b;Wang et al, 2009).…”

Schizophrenic micellization of poly(ethylene oxide-b-methacrylic acid) induced by phosphate and calcium ions

“…All the measurements for the PMAA-core micelles were carried out at pH 9 as almost all the PMAAs (pKa = 5.5) [26,27] get completely ionized at this pH. The pH of the solution was adjusted using 0.01 M sodium hydroxide and 0.01 M hydrochloric acid.…”