Preparation and identification of peptides and their zinc complexes with antimicrobial activities from silver carp ( Hypophthalmichthys molitrix ) protein hydrolysates

Jiang, Liangping; Wang, Bo; Лі, Бо; Wang, Chan

doi:10.1016/j.foodres.2014.06.008

Cited by 46 publications

(26 citation statements)

References 34 publications

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“…Anionic AMPs have a large number of negatively charged aspartic and glutamic acid residues ( Lakshmaiah Narayana and Chen, 2015 ). They require zinc as a functional cofactor and the zinc complex shows stronger antibacterial activity ( Jiang et al, 2014 ). Several of these AMPs use metal ions to form cationic salt bridges with the negatively charged components of the microbial membrane to penetrate the membrane.…”

Section: Environmental Factors Affecting the Activity Of Antimicrobiamentioning

confidence: 99%

Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields

et al. 2020

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Antimicrobial peptides (AMPs) are a class of small peptides that widely exist in nature and they are an important part of the innate immune system of different organisms. AMPs have a wide range of inhibitory effects against bacteria, fungi, parasites and viruses. The emergence of antibiotic-resistant microorganisms and the increasing of concerns about the use of antibiotics resulted in the development of AMPs, which have a good application prospect in medicine, food, animal husbandry, agriculture and aquaculture. This review introduces the progress of research on AMPs comprehensively and systematically, including their classification, mechanism of action, design methods, environmental factors affecting their activity, application status, prospects in various fields and problems to be solved. The research progress on antivirus peptides, especially anti-coronavirus (COVID-19) peptides, has been introduced given the COVID-19 pandemic worldwide in 2020.

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Section: Environmental Factors Affecting the Activity Of Antimicrobiamentioning

confidence: 99%

Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields

et al. 2020

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“…Digestion of casein yields physiologically important bioactive peptides, which play an important role in the nervous, cardiovascular, digestive, and immune systems (Kitts, 2005;Silva and Malcata, 2005). Researchers are becoming interested in various peptides within the casein system, such as antioxidant peptides (De Gobba et al, 2014), angiotensin-converting enzyme (ACE) inhibitory peptides (Contreras et al, 2009), immunomodulatory peptides (Malinowski et al, 2014), and metal-chelating peptides (Jiang et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Charge properties of peptides derived from casein affect their bioavailability and cytoprotection against H2O2-induced oxidative stress

Wang

Xie

Лі

2016

Journal of Dairy Science

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The effects of charge properties of casein peptides on absorption stability, antioxidant activity, and cytoprotection were evaluated. Alcalase hydrolysates of casein were separated into 4 fractions by cation-exchange chromatography according to charge properties. After simulated digestion and Caco-2 cell transmembrane transport, we determined the total antioxidant capacity (Trolox equivalent antioxidative capacity and oxygen radical antioxidant activity) and nitrogen content of peptide fractions to estimate available antioxidant efficacy and bioavailability (BA) of peptides. Results showed that negatively charged peptide fractions had greater BA and antioxidant activities after digestion and absorption. The peptide permeates were used to test the cytoprotective effect against H2O2-induced oxidative damage in HepG-2 cells. All peptide permeates increased cell viability, elevated catalase activity, and decreased superoxide dismutase activity. However, negatively charged peptide fractions preserved cell viability to a greater degree. Therefore, the negatively charged peptides from casein may be potential antioxidants and could be used as ingredients in functional foods and dietary supplements.

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“…The DH observed in this work was more than values reported for silver carp protein hydrolysate (8.1%). 15 …”

Section: Discussionmentioning

confidence: 99%

Purification and Characterization of Novel Collagen Peptides against Platelet Aggregation and Thrombosis from Salmo salar

et al. 2020

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Collagen is a rich source of bioactive peptides and is widely distributed in the skin and bone tissue. In this study, collagen from Salmo salar skin was hydrolyzed with Alcalase or Protamex followed by simulated digestion, YMC ODS-A C18 separation, and ESI-MS/MS analysis. A total of 19 peptides were identified and synthesized for investigation of their antiplatelet activities. Hyp-Gly-Glu-Phe-Gly (OGEFG) and Asp-Glu-Gly-Pro (DEGP) exhibited the most potent activity against ADP-induced platelet aggregation among them with IC 50 values of 277.17 and 290.00 μM, respectively, and inhibited the release of β-TG and 5-HT in a dose-dependent manner significantly. Single oral administration of OGEFG and DEGP also inhibited thrombus formation in a ferric chloride-induced arterial thrombosis model at a dose of 200 μmol/kg body weight and did not prolong the bleeding time or cause an immune response in mice. Therefore, our findings indicated that collagen peptides had a potential to be developed into an effective specific medical food in the prevention of thrombotic diseases.

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Preparation and identification of peptides and their zinc complexes with antimicrobial activities from silver carp ( Hypophthalmichthys molitrix ) protein hydrolysates

Cited by 46 publications

References 34 publications

Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields

Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields

Charge properties of peptides derived from casein affect their bioavailability and cytoprotection against H2O2-induced oxidative stress

Purification and Characterization of Novel Collagen Peptides against Platelet Aggregation and Thrombosis from Salmo salar

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