Preparation and Properties of Liposomes Composed of Various Phospholipids with Different Hydrophobic Chains Using a Supercritical Reverse Phase Evaporation Method

Sakai, Hideki; Gotoh, Toshihiro; Imura, Tomohiro; Sakai, Kenichi; Otake, Katsuto; Abe, Masahiko

doi:10.5650/jos.57.613

Cited by 24 publications

(11 citation statements)

References 51 publications

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“…DOPC) demonstrated a higher EE than those liposomes using saturated phospholipids (e.g. DPPC) [84]. The EE was more dependent on the number of unsaturated bonds than on the alkyl chain length of the phospholipid molecule [84].…”

Section: Hydrophilic Bioactive Agentsmentioning

confidence: 89%

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Liposomes in tissue engineering and regenerative medicine

Monteiro

Martins

Reis

et al. 2014

J. R. Soc. Interface.

329

217

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Liposomes are vesicular structures made of lipids that are formed in aqueous solutions. Structurally, they resemble the lipid membrane of living cells. Therefore, they have been widely investigated, since the 1960s, as models to study the cell membrane, and as carriers for protection and/or delivery of bioactive agents. They have been used in different areas of research including vaccines, imaging, applications in cosmetics and tissue engineering. Tissue engineering is defined as a strategy for promoting the regeneration of tissues for the human body. This strategy may involve the coordinated application of defined cell types with structured biomaterial scaffolds to produce living structures. To create a new tissue, based on this strategy, a controlled stimulation of cultured cells is needed, through a systematic combination of bioactive agents and mechanical signals. In this review, we highlight the potential role of liposomes as a platform for the sustained and local delivery of bioactive agents for tissue engineering and regenerative medicine approaches.

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Section: Hydrophilic Bioactive Agentsmentioning

confidence: 89%

“…DPPC) [84]. The EE was more dependent on the number of unsaturated bonds than on the alkyl chain length of the phospholipid molecule [84].…”

Section: Hydrophilic Bioactive Agentsmentioning

confidence: 93%

Liposomes in tissue engineering and regenerative medicine

Monteiro

Martins

Reis

et al. 2014

J. R. Soc. Interface.

329

217

View full text Add to dashboard Cite

show abstract

“…High drug entrapment efficiency in liposomes is yielded when they are prepared from unsaturated phospholipids. [ 113 ] This approach was later utilized to develop various drug formulations using SCF after optimization of formulation variables. [ 114 ] Although much research has been done in preparing liposomes through the SCF technology, the scalability and industrial implementation of these processes are expensive.…”

Section: Drug Deliverymentioning

confidence: 99%

Supercritical Fluid Technology: An Emphasis on Drug Delivery and Related Biomedical Applications

Kankala

Zhang

Wang

et al. 2017

Adv Healthcare Materials

233

184

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During the past few decades, supercritical fluid (SCF) has emerged as an effective alternative for many traditional pharmaceutical manufacturing processes. Operating active pharmaceutical ingredients (APIs) alone or in combination with various biodegradable polymeric carriers in high-pressure conditions provides enhanced features with respect to their physical properties such as bioavailability enhancement, is of relevance to the application of SCF in the pharmaceutical industry. Herein, recent advances in drug delivery systems manufactured using the SCF technology are reviewed. We provide a brief description of the history, principle, and various preparation methods involved in the SCF technology. Next, we aim to give a brief overview, which provides an emphasis and discussion of recent reports using supercritical carbon dioxide (SC-CO2) for fabrication of polymeric carriers, for applications in areas related to drug delivery, tissue engineering, bio-imaging, and other biomedical applications. We finally summarize with perspectives.

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“…Critical packing parameter (CPP) can be defined as the parameter governing the packing of phospholipids together [46] . Phospholipids possessing larger CPP form larger liposomes with higher entrapment efficiency [47] . Sakai et al reported that trapping efficiency increases on increasing the unsaturated bonds and bulkiness of the molecule [47] .…”

Section: Properties Of Glycerosomes Mo-lecular Geometrymentioning

confidence: 99%

“…Phospholipids possessing larger CPP form larger liposomes with higher entrapment efficiency [47] . Sakai et al reported that trapping efficiency increases on increasing the unsaturated bonds and bulkiness of the molecule [47] . CPP=v/lc AP, CPP=AhP/AP, where v/lc is AhP, v is the volume of hydrophobic groups, lc is the hydrophobic group length, AP is the cross sectional area of hydrophilic head group and Ahp is the cross sectional area of hydrophobic head group.…”

Section: Properties Of Glycerosomes Mo-lecular Geometrymentioning

confidence: 99%

Glycerosomes: Advanced Liposomal Drug Delivery System

Gupta¹,

Mazumder²,

Padhi³

2020

Indian J Pharm Sci

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Gupta et al.: Glycerosomal Drug Delivery Systems Although liposomes have proved to be versatile in the field of drug delivery, there are still some issues that need to be addressed mainly problems related to entrapment, penetration, fluidity and stability. Glycerosomes represent a novel drug delivery systems composed of phospholipids, water and glycerol in varying amounts. Glycerosomes are upgraded versions of liposomes meant for topical and transdermal drug delivery. In these preparations, glycerol acts as an edge activator and penetration enhancer. These drug delivery systems manifest improved stability, fluidity, entrapment and penetration in comparison to conventional liposomes. Increasing the concentration of glycerol by 10, 20 or 30 % leads to a drastic increase in glycerosome stability. This article is a detailed review of glycerosomes focusing on methods of preparation, evaluation, applications, advantages and disadvantages based on studies reported so far. In this review article, how the structure of liposomes can be modified by the addition of glycerol and how this modified structure can be used to address the problems related to liposomes is discussed. The influence of increasing glycerol concentration on the nature of glycerosomes that lead to an increase in both entrapment and encapsulation of a drug while causing slower drug release is discussed.

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Preparation and Properties of Liposomes Composed of Various Phospholipids with Different Hydrophobic Chains Using a Supercritical Reverse Phase Evaporation Method

Cited by 24 publications

References 51 publications

Liposomes in tissue engineering and regenerative medicine

Liposomes in tissue engineering and regenerative medicine

Supercritical Fluid Technology: An Emphasis on Drug Delivery and Related Biomedical Applications

Glycerosomes: Advanced Liposomal Drug Delivery System

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