Preparation of curcumin nanoparticle by using reinforcement ionic gelation technique

Suryani, Suryani; Halid, Nur Hatidjah Awaliyah; Akib, Nur Illiyyin; Rahmanpiu,; Mutmainnah, Nina

doi:10.1063/1.4982185

Cited by 7 publications

(6 citation statements)

References 6 publications

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“…The percentage encapsulation efficiency of the prepared nanoparticles was found to be in the range of 91% to 95% (Table 2 ). High Encapsulation Efficiency could be attributed to curcumin alginate interactions (Hydrophilic and Hydrophobic) [23]. Higher EE values obtained in our formulations imply that formulation composition and protocol aresatisfactory and suitable for industrial scale up.…”

Section: Resultsmentioning

confidence: 90%

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Enhanced Water Dispersibility of Curcumin Encapsulated in Alginate-Polysorbate 80 Nano Particles and Bioavailability in Healthy Human Volunteers

Govindaraju¹,

Karki

Chandrashekarappa³

et al. 2019

PNT

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Background: The turmeric (Curcuma longa) plant, a perennial herb of the ginger family, is an agronomic crop in the south and southeast tropical Asia. Turmeric an Indian yellow gold and universal spice is described in Ayurveda, an ancient treatise on longevity and quality life for the treatment of various inflammatory disorders. The oral bioavailability of curcumin is low due to poor aqueous solubility, alkaline instability and speedy elimination. Objective: The present study is designed to prepare alginate polysorbate 80 nanoparticles to enhance aqueous solubility/dispersibility, hence bioavailability. Method: Curcumin-loaded alginate - polysorbate 80 nanoparticles were prepared by ionotropic gelation technique. Results: The optimized nano particles exhibited higher encapsulation efficiency (95%), particle size of 383 nm and Zeta potential of +200 mV. Formulations exhibited very low dissolution in Simulated Gastric Fluid (SGF) and Simulated Intestinal Fluid (SIF), but the major portion released in SCF which is attributed to the digestibility of alginate in Simulated Colonic Fluid (SCF) under the influence of colonic micro flora. FTIR and DSC observations revealed the successful entrapment of curcumin in alginate polysorbate-80 nanoparticles. The nanoparticles were more spherical, discrete and homogeneous. In healthy human volunteers, the oral bioavailability (AUC) of curcumin increased 5-fold after the consumption of curcumin nanosuspension compared to curcumin suspension. Maximum plasma concentration Cmax- 636 ± 122 ng/ml was observed at tmax- 2h for nanosuspension, whereas Cmax-87.7 ± 17.9ng/ml at tmax- 4h for suspension. Conclusion: Curcumin-loaded alginate - polysorbate 80 nanoparticles prepared by ionotropic gelation method, successfully entrapped curcumin. Both curcumin suspension and curcumin nanosuspension were safe and well tolerated and may thus be useful in the prevention or treatment of various inflammatory diseases of mankind.

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Section: Resultsmentioning

confidence: 90%

“…Zc, optimized formulations have an average of 383 ± 7 nm. The Polydispersity index (PDI) is 0.2, PDI nearer to zero implies homogeneity of dispersions and greater than 0.3 indicates heterogeneity [23]. The observations suggest that concentration of sodium alginate and polysorbate 80 can be tailored to get the desired particle size.…”

Section: Resultsmentioning

confidence: 99%

Enhanced Water Dispersibility of Curcumin Encapsulated in Alginate-Polysorbate 80 Nano Particles and Bioavailability in Healthy Human Volunteers

Govindaraju¹,

Karki

Chandrashekarappa³

et al. 2019

PNT

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“…Curcumin nanoparticles were taken from the Laboratory of Pharmaceutics, Faculty of Pharmacy, Halu Oleo University, Kendari, Indonesia. Curcumin nanoparticles were formulated from chitosan and tripolyphosphate (the reinforcement ionic gelation method) [4]. Other materials included HPMC (ShimEtsu, Japan), EC n10 (Hercules, USA),chloroform (Merck, Germany), NaOH (Brataco, Indonesia), polyethylene glycol 400 (PEG 400) (Merck, Germany), dichloromethane (Merck, Germany), potassium dihydrogen phosphate (Merck, Germany), ethanol (Brataco, Indonesia), menthol (Brataco, Indonesia), white rats (Rattus Norvegicus), and distilled water (Brataco, Indonesia).…”

Section: Methodsmentioning

confidence: 99%

“…One way to overcome this limitation is by formulating drugs as nanoparticles. In our previous work, we formulated curcumin nanoparticles from chitosan polymers and tripolyphosphate [4] and provided good characteristics of curcumin nanoparticles. The use of chitosan could affect the permeation rate of active agents [5].…”

Section: Introductionmentioning

confidence: 99%

Formulation and Physical Characterization of Curcumin Nanoparticle Transdermal Patch

et al. 2019

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Objective: This study was conducted to formulate curcumin nanoparticles transdermal patches and to evaluate their physical characterization. Methods: Curcumin nanoparticles transdermal patches were formulated by the casting evaporation method. Transdermal patches were made using combinations of hydroxypropyl methylcellulose (HPMC) and ethyl cellulose (EC) at ratios of 4.5:1.5 for Formula 1 (F1), 4:1 for Formula 2 (F2), 3.5:1.5 for Formula 3 (F3), 3:2 for Formula 4 (F4), and 2.5:2.5 for Formula 5 (F5). Physical characterization evaluation (organoleptic properties, pH, weight uniformity, thickness uniformity, percent moisture content, and tensile strength) was then performed. The permeation of curcumin nanoparticles into the skin was evaluated using Franz diffusion cells. Results: Curcumin nanoparticles transdermal patches could be formulated by the casting evaporation method with the organoleptic properties characterized as smooth, dry, yellow in color, having menthol odor, and transparent. The pH values ranged between 5.0 and 6.0. The thickness of the patches ranged from 0.1 to 0.2 mm. The average of the patches’ weight was 0.7 g, and the percent moisture content ranged from 1.0 to 6.0%. The tensile strength values were 1.0 to 2.0 N/mm. Curcumin nanoparticles could penetrate into the skin with flux values being 1.271 µg. cm-2 (F1), 0.938 µg. cm-2 (F2), 0.775 µg. cm-2 (F3), 0.837 µg. cm-2 (F4), and 0.569 µg. cm-2 (F5). Conclusion: All patches met the requirement of the physical characterization for the transdermal patch.

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“…Furthermore, curcumin has been incorporated into CS-ALG sponge to improve its wound healing property 33,34. More recently, curcumin NPs have been produced by using CS, ALG, TPP, and calcium chloride 35. Regarding the necessity of finding an alternative drug delivery system for cancer therapy, the present study describes a new approach for loading curcumin onto CS, ALG, and STPP NPs by an ultrasonic-assisted method.…”

Section: Introductionmentioning

confidence: 99%

Induction of apoptosis in HeLa cancer cells by an ultrasonic-mediated synthesis of curcumin-loaded chitosan–alginate–STPP nanoparticles

Ahmadi¹,

Ghasemi-Kasman²,

Ghasemi³

et al. 2017

IJN

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Natural herbal compounds have been widely introduced as an alternative therapeutic approach in cancer therapy. Despite potent anticancer activity of curcumin, its clinical application has been limited because of low water solubility and resulting poor bioavailability. In this study, we designed a novel ultrasonic-assisted method for the synthesis of curcumin-loaded chitosan–alginate–sodium tripolyphosphate nanoparticles (CS-ALG-STPP NPs). Furthermore, antitumor effect of curcumin-loaded NPs was evaluated in vitro. Field emission scanning electron microscopy (FE-SEM) and atomic force microscopy (AFM) were used to characterize the properties of NPs. Antitumor activity of curcumin-loaded NPs was assessed by using MTT and quantitative real-time polymerase chain reaction (qRT-PCR). FE-SEM and AFM data revealed the spherical morphology, and the average size of NPs was <50 nm. In vitro cytotoxicity assay suggested that curcumin-loaded CS-ALG-STPP NPs displayed significant antitumor activity compared with the free curcumin. Gene expression level analyses showed that curcumin NPs significantly increased the apoptotic gene expression. Collectively, our results suggest that curcumin-loaded NPs significantly suppressed proliferation and promoted the induction of apoptosis in human cervical epithelioid carcinoma cancer cells, which might be regarded as an effective alternative strategy for cancer therapy.

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Preparation of curcumin nanoparticle by using reinforcement ionic gelation technique

Cited by 7 publications

References 6 publications

Enhanced Water Dispersibility of Curcumin Encapsulated in Alginate-Polysorbate 80 Nano Particles and Bioavailability in Healthy Human Volunteers

Enhanced Water Dispersibility of Curcumin Encapsulated in Alginate-Polysorbate 80 Nano Particles and Bioavailability in Healthy Human Volunteers

Formulation and Physical Characterization of Curcumin Nanoparticle Transdermal Patch

Induction of apoptosis in HeLa cancer cells by an ultrasonic-mediated synthesis of curcumin-loaded chitosan–alginate–STPP nanoparticles

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Preparation of curcumin nanoparticle by using reinforcement ionic gelation technique

Cited by 7 publications

References 6 publications

Enhanced Water Dispersibility of Curcumin Encapsulated in Alginate-Polysorbate 80 Nano Particles and Bioavailability in Healthy Human Volunteers

Enhanced Water Dispersibility of Curcumin Encapsulated in Alginate-Polysorbate 80 Nano Particles and Bioavailability in Healthy Human Volunteers

Formulation and Physical Characterization of Curcumin Nanoparticle Transdermal Patch

Induction of apoptosis in HeLa cancer cells by an ultrasonic-mediated synthesis of curcumin-loaded chitosan&ndash;alginate&ndash;STPP nanoparticles

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Induction of apoptosis in HeLa cancer cells by an ultrasonic-mediated synthesis of curcumin-loaded chitosan–alginate–STPP nanoparticles