Presentation of a new magnetic field therapy system for the treatment of human solid tumors with magnetic fluid hyperthermia

Jordan, Andreas; Scholz, Robert; Maier-Hauff, K.; Johannsen, Manfred; Wust, Peter; Nadobny, Jacek; Schirra, Hermann; Schmidt, Helmut K.; Değer, Serdar; Loening, Stefan A.; Lanksch, W.; Félix, R.

doi:10.1016/s0304-8853(00)01239-7

Cited by 682 publications

(420 citation statements)

References 11 publications

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“…The principle of heating with superparamagnetic particles (that show no magnetic hysteresis at low frequencies) by an AC field has been reviewed by Rosensweig (2002): the dissipation results from the orientational relaxation of the particles having thermal fluctuations in a viscous medium (Hergt et al 1998). A number of studies have demonstrated the therapeutic efficacy of this form of treatment in animal models (for a review, see, for example, Moroz et al (2002)), but the application of this technology to human patients is just starting (Jordan et al 2001). …”

Section: Hyperthermiamentioning

confidence: 99%

Magnetic bead handling on-chip: new opportunities for analytical applications

Gijs

2004

Microfluid Nanofluid

497

555

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This review describes recent advances in the handling and manipulation of magnetic particles in microfluidic systems. Starting from the properties of magnetic nanoparticles and microparticles, their use in magnetic separation, immuno-assays, magnetic resonance imaging, drug delivery, and hyperthermia is discussed. We then focus on new developments in magnetic manipulation, separation, transport, and detection of magnetic microparticles and nanoparticles in microfluidic systems, pointing out the advantages and prospects of these concepts for future analysis applications.

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Section: Hyperthermiamentioning

confidence: 99%

Magnetic bead handling on-chip: new opportunities for analytical applications

Gijs

2004

Microfluid Nanofluid

497

555

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“…A recently developed method of local hyperthermia is magnetic fluid hyperthermia, which involves the injection of magnetic nanoparticles that are suspended in a fluid either intravenously, or directly into the tumour site [5]. Once the magnetic nanoparticles are in place at the tumour site, an alternating magnetic field is then applied to the local area.…”

Section: Introductionmentioning

confidence: 99%

Energy losses in interacting fine-particle magnetic composites

Burrows¹,

Parker²,

Evans³

et al. 2010

J. Phys. D: Appl. Phys.

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Abstract. The coercivity and energy losses in superparamagnetic magnetite and FePt nanoparticle composites subjected to an external, alternating magnetic field have been calculated as a function of the mean particle-size and packing density. The effect of interactions has been investigated by fitting the Sharrock law to the coercivity results as a function of the field cycle frequency of the magnetic field. This fitting leads to effective parameters for the anisotropy field H ef f K and β ef f = KV /k B T , which are themselves dependent on the interaction strength. The increase or decrease of the coercivity with interactions depends upon the relative change of H ef f K and β ef f , thus demonstrating the complex effect that interactions have in these nanoparticle composites. The interparticle interactions have a non-trivial effect on the energy loss per cycle. The energy loss is reduced for systems with larger particles since the reduction in coercivity together with a corresponding reduction in the remanence dominates. For small particle sizes, the energy loss is increased. The primary mechanism here seems to be an enhancement of the energy barrier due to interactions, which changes the nature of the particles from superparamagnetic to being thermally stable.

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“…Similar self-assembled aggregates must be produced for a number of biomedical applications such as magnetic drug targeting ͑MDT͒, 10,11 magnetic fluid hyperthermia, 12 and magnetic resonance imaging ͑MRI͒ contrast enhancement. 13 MDT is a promising technique for the treatment of various diseases and cardiovascular episodes such as stenosis and thrombosis.…”

Section: Introductionmentioning

confidence: 99%

Field-induced self-assembled ferrofluid aggregation in pulsatile flow

2005

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Ferrofluid aggregation and dispersion occurs at several length scales in pulsatile flow applications, e.g., in ferrofluidic pumps, valves, and biomedical applications such as magnetic drug targeting. Because of a yet limited understanding, ferrohydrodynamic investigations involving laboratoryscale studies in idealized geometries are of considerable use. We have injected a ferrofluid into a pulsatile host flow and produced field-induced dissolution ͑aggregation͒ using external magnets. A comparison is made with ferrofluid aggregation in a steady flow. Subsequently, the accumulation and dispersion of the ferrofluid aggregates in pulsatile flow are characterized by analyzing their size, mean position, and the flow frequency spectrum. The maximum aggregate size A max , time to form it t max , and the aggregate half-life t half are found to scale according to the relations A max ϰ Re −0.71 , t max ϰ Re −2.1 , and t half ϰ Re −2.2 . While the experiments are conducted at a macroscopic length scale for useful experimental resolution, the results also enable an understanding of the micro-and mesoscale field-assisted self-assembly of magnetic nanoparticles.

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Presentation of a new magnetic field therapy system for the treatment of human solid tumors with magnetic fluid hyperthermia

Cited by 682 publications

References 11 publications

Magnetic bead handling on-chip: new opportunities for analytical applications

Magnetic bead handling on-chip: new opportunities for analytical applications

Energy losses in interacting fine-particle magnetic composites

Field-induced self-assembled ferrofluid aggregation in pulsatile flow

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