Prevention of Transmission of Multidrug-Resistant Organisms during Catheter Exchange using Antimicrobial Catheters

Mohamed, Jamal A.; Rosenblatt, Joel; Jiang, Ying; Hachem, Ray; Chaftari, Anne-Marie; Raad, Issam

doi:10.1128/aac.02886-14

Cited by 14 publications

(9 citation statements)

References 32 publications

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“…Catheter‐related complications, such as malfunction and displacement, and patient/family preferences are also indications for GCE. Different studies performed in adult populations have suggested that GCE is associated with a low complication rate and without an increased risk of infection . However, these findings have not been confirmed in children with malignancies.…”

Section: Introductionmentioning

confidence: 69%

“…evaluated prospectively the usefulness of GCE for the treatment of infected CVCs in 17 patients undergoing HSCT or intensive chemotherapy and concluded that GCE during adequate antimicrobial therapy may be a reasonable option for the treatment of CLABSI when antimicrobial therapy alone has been unsuccessful. Some studies have suggested that GCE with antibiotic‐coated CVCs could prevent CLABSI and be an alternative for removing the CVC and de novo insertion . Minocycline/rifampin‐coated CVCs have been used.…”

Section: Discussionmentioning

confidence: 99%

“…Different studies performed in adult populations have suggested that GCE is associated with a low complication rate and without an increased risk of infection. [13][14][15][16] However, these findings have not been confirmed in children with malignancies. The aim of the present study was to evaluate the indications, postoperative complications, and outcomes of GCE in pediatric cancer patients.…”

Section: Introductionmentioning

confidence: 99%

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Guidewire Catheter Exchange in Pediatric Oncology: Indications, Postoperative Complications, and Outcomes

Fernández-Pineda

Ortega-Laureano

et al. 2016

Pediatric Blood & Cancer

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Section: Introductionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Guidewire Catheter Exchange in Pediatric Oncology: Indications, Postoperative Complications, and Outcomes

Fernández-Pineda

Ortega-Laureano

et al. 2016

Pediatric Blood & Cancer

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“…According to Stocco et al (2016), depending on the tested micro-organism, there will be a short time to CVC colonization. Two in vitro studies of Jamal et al (2014aJamal et al ( , 2014b informed that CHX/ SS-coated CVCs were not as effective in inhibiting biofilm colonization by several resistant Gram-negative and Gram-positive bacteria, including K. pneumoniae, as CHX/M-R (minocycline-rifampin). The authors considered that the CHX-M/R catheters exhibited better antimicrobial durability and were more effective than CHX/SS among others.…”

Section: Discussionmentioning

confidence: 99%

In vitro activity of antimicrobial‐impregnated catheters against biofilms formed by KPC‐producing Klebsiella pneumoniae

et al. 2019

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Aim To evaluate the activity and effectiveness of impregnated central venous catheters (CVC) against Klebsiella pneumoniae biofilms. Methods and Results The antimicrobial activity and durability of impregnated‐CVCs were evaluated over time and the size of zones of inhibition (ZI) was measured. Biofilm formation was observed by quantitative culture and also by scanning electron microscopy. The catheters impregnated with chlorhexidine/silver sulfadiazine (CHX/SS) reduced bacteria counts by 0·3 log and were most effective (P < 0·01) against Klebsiella pneumoniae biofilms N‐acetylcysteine/levofloxacin (NAC/LEV) catheters. It was observed that the catheter impregnated with NAC/LEV had initially the largest average ZI size being statistically significant (P < 0·01). The NAC/LEV combination remained active until day 30, whereas the combination of CHX/SS was completely inactivated from day 15 on. Conclusions The NAC/LEV combination showed greater durability on the catheters, but it was the CHX/SS combination that had the greater initial efficacy in bacterial inhibition. It was also observed that NAC/LEV‐impregnated catheters do not prevent the emergence of resistant subpopulations inside the inhibition halos during antimicrobial susceptibility tests. Significance and Impact of the Study Our results highlighted that the in vitro efficacy of antimicrobial‐impregnated CVCs is limited by time and that their colonization occurred earlier than expected. Our data also demonstrated that NAC/LEV remained active until day 30 of evaluation and CHX/SS combination was completely inactivated from day 15 on. Our findings suggested that implantable devices should be carefully used by medical community.

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“…Furthermore, CHX-M/R CVCs showed superior activity against P. aeruginosa and C. albicans to M/R catheters and were superior to CHX/SS CVCs against MRSA and P. aeruginosa ( Jamal et al 2014 ).…”

Section: Prevention Of Clabsismentioning

confidence: 99%

Biofilm-Based Central Line-Associated Bloodstream Infections

Yousif

Mohamed

Raad

2014

Advances in Experimental Medicine and Biology

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Different types of central venous catheters (CVCs) have been used in clinical practice to improve the quality of life of chronically and critically ill patients. Unfortunately, indwelling devices are usually associated with microbial biofilms and eventually lead to catheter-related bloodstream infections (CLABSIs).An estimated 250,000-400,000 CLABSIs occur every year in the United States, at a rate of 1.5 per 1,000 CVC days and a mortality rate of 12-25 %. The annual cost of caring for patients with CLABSIs ranges from 296 million to 2.3 billion dollars.Biofilm formation occurs on biotic and abiotic surfaces in the clinical setting. Extensive studies have been conducted to understand biofilm formation, including different biofilm developmental stages, biofilm matrix compositions, quorum-sensing regulated biofilm formation, biofilm dispersal (and its clinical implications), and multi-species biofilms that are relevant to polymicrobial infections.When microbes form a matured biofilm within human hosts through medical devices such as CVCs, the infection becomes resistant to antibiotic treatment and can develop into a chronic condition. For that reason, many techniques have been used to prevent the formation of biofilm by targeting different stages of biofilm maturation. Other methods have been used to diagnose and treat established cases of CLABSI.Catheter removal is the conventional management of catheter associated bacteremia; however, the procedure itself carries a relatively high risk of mechanical complications. Salvaging the catheter can help to minimize these complications.In this article, we provide an overview of microbial biofilm formation; describe the involvement of various genetic determinants, adhesion proteins, organelles, mechanism(s) of biofilm formation, polymicrobial infections, and biofilm-associated infections on indwelling intravascular catheters; and describe the diagnosis, management, and prevention of catheter-related bloodstream infections.

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Prevention of Transmission of Multidrug-Resistant Organisms during Catheter Exchange using Antimicrobial Catheters

Cited by 14 publications

References 32 publications

Guidewire Catheter Exchange in Pediatric Oncology: Indications, Postoperative Complications, and Outcomes

Guidewire Catheter Exchange in Pediatric Oncology: Indications, Postoperative Complications, and Outcomes

In vitro activity of antimicrobial‐impregnated catheters against biofilms formed by KPC‐producing Klebsiella pneumoniae

Biofilm-Based Central Line-Associated Bloodstream Infections

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