Preventive effect of ethanol extract from Chinese sumac fruits against tetrachloromethane-induced liver fibrosis in mice

Zhou, Jiexin; Liu, Xiaojing; Chen, Taiming; Cheng, Guiguang; Cai, Shengbao

doi:10.1039/d0fo00548g

Cited by 21 publications

(11 citation statements)

References 33 publications

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“…Our previous study had reported that different extracts of R. chinensis fruits exhibited strong ABTS and DPPH radical scavenging activities [10]. Moreover, the ethanol extract of R. chinensis fruits can improve the antioxidant defensive systems in rats with nonalcoholic fatty liver and mice with fibrosis liver in vivo [11,12]. According to those results, it is reasonable to assume that the good inhibitory effect of those extracts toward AGEs formation may be due to their good antioxidant activities.…”

Section: Resultsmentioning

confidence: 99%

“…Rhus chinensis Mill., also known as Chinese sumac, is commonly used as a herb to treat inflammation, diarrhea, malaria, jaundice, alcoholic toxicity and phlegm according to the record of Traditional Chinese Medicine [9]. Previous studies had confirmed that R. chinensis fruits possessed several bioactivities, such as antioxidant and pancreatic lipase inhibitory effects in vitro [10], prevention of liver fibrosis [11], nonalcoholic fatty liver [12] and alcoholic fatty liver [13] in vivo . However, no study has been performed to investigate the in vitro anti‐diabetic effect of R. chinensis fruits.…”

Section: Introductionmentioning

confidence: 99%

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Anti‐Diabetic Effects of Different Phenolic‐Rich Fractions from Rhus Chinensis Mill. Fruits in vitro

Liu

et al. 2021

eFood

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This study investigated the inhibitory effects of the Ethanol Extract (EE), Free Phenolic (TF), Esterified Phenolic (TE) and Insoluble-bound Phenolic (TI) from Rhus chinensis Mill. fruits on a-glucosidase, Dipeptidyl Peptidase-4 (DPP-IV), and the formation of Advanced Glycation End (AGE) products. Results showed that the TF had the strongest inhibition against a-glucosidase and DPP-IV with IC 50 of 0.56 ± 0.04 and 66.08 ± 1.36 μg/mL, respectively (p < 0.05). TI exhibited the strongest inhibitory effect on the formation of AGEs with IC 50 of 0.43 ± 0.03 mg/mL (p < 0.05). Two major compounds (myricetin-3-Orhamnoside and quercetin-3-O-rhamnoside) showed additive or synergistic effects on a-glucosidase inhibition, while displayed antagonistic effect on DPP-IV inhibition. Correlation analysis indicated that myricetin-3-O-(6″-galloyl) glycoside and myricetin O-gallate contributed significantly on a-glucosidase inhibition, while di-O-galloyl-glucoside and its isomer may contribute remarkably toward DPP-IV inhibition. Protocatechuic acid and myricetin-3-O-rhamnoside showed a positive correlation with the suppression of AGEs formation. Those results may provide some scientific information for exploring R. chinensis fruits as nutraceuticals and/or functional foods to prevent or improve diabetes.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anti‐Diabetic Effects of Different Phenolic‐Rich Fractions from Rhus Chinensis Mill. Fruits in vitro

Liu

et al. 2021

eFood

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“…Further analysis revealed that the molecular mechanisms were mainly concentrated in the immune and inflammatory pathways, with the main pathway being the classical IL-17 signaling pathway (Supplementary Figure S1). The key targets of the IL-17 signaling pathway include NF-κB, AP-1, IL-6, IL-1β, TNFα, IFN-γ, CCL2, COX2, MMP1, MMP3, and MMP9, which all exert vital parts in HF development (Tan et al, 2020;Zhou et al, 2020). Accordingly, in addition to the network pharmacology analysis, we next performed experimental validation to clarify the potential inflammatory mechanism of the flavonoids against liver fibrosis.…”

Section: Discussionmentioning

confidence: 99%

Integrating Network Pharmacology and Experimental Validation to Investigate the Effects and Mechanism of Astragalus Flavonoids Against Hepatic Fibrosis

Lin

et al. 2021

Front. Pharmacol.

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Hepatic fibrosis (HF) represents the excessive wound healing where an excess amount of connective tissues is formed within the liver, finally resulting in cirrhosis or even hepatocellular carcinoma (HCC). Therefore, it is significant to discover the efficient agents and components to treat HF, thus restraining the further progression of hepatopathy. Astragalus membranaceus (Fisch.) Bunge [also called Astragali Radix (AR)] is a famous herb in traditional Chinese medicine (TCM), which possesses a variety of biological activities and exerts good therapeutic effects in the treatment of HF. Flavonoids account for the major active ingredients related to the AR pharmacological effects. Total AR flavonoids have been proved to exert inhibitory effects on hepatic fibrosis. This study aimed to further undertake network pharmacology analysis coupled with experimental validation and molecular docking to investigate the effects and mechanism of multiple flavonoid components from AR against liver fibrosis. The results of the network pharmacology analysis showed that the flavonoids from AR exerted their pharmacological effects against liver fibrosis by modulating multiple targets and pathways. The experimental validation data showed that the flavonoids from AR were able to suppress transforming growth factor beta 1 (TGF-β1)-mediated activation of hepatic stellate cells (HSCs) and reduce extracellular matrix deposition in HSC-T6 cells via regulating the nuclear factor kappa B (NF-κB) signal transduction pathway. The results of the molecular docking study further showed that the flavonoids had a strong binding affinity for IκB kinase (IKKβ) after docking into the crystal structure. The above results indicated that, flavonoids possibly exerted the anti-inflammatory effect on treating HF by mediating inflammatory signaling pathways. The potential mechanism of these flavonoids against liver fibrosis may be related to suppression of the NF-κB pathway through effective inhibition of IKKβ. This study not only provides a scientific basis for clarifying the effects and mechanism of AR flavonoids against liver fibrosis but also suggests a novel promising therapeutic strategy for the treatment of liver fibrosis.

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“…treatment group (YH). The intervention doses used in this study were referenced as previously described [ 25 ]. Mice in group C were fed with a normal diet, while mice in groups M, YL, and YH were fed with a model diet containing 0.1% DDC.…”

Section: Methodsmentioning

confidence: 99%

Protective Effect of Rhus chinensis Mill. Fruits on 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine-Induced Cholestasis in Mice via Ameliorating Oxidative Stress and Inflammation

et al. 2022

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This study focused on the preventive effects of the extracts of Rhus chinensis Mill. (RCM) fruits on cholestasis induced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) in mice. The results showed that RCM extracts could significantly ameliorate DDC-induced cholestasis via multiple mechanisms, including (1) alleviating liver damage via enhancing antioxidant capacity, such as increasing the contents of glutathione, superoxide dismutase, and catalase and inhibiting the levels of malondialdehyde; (2) preventing liver inflammation by suppressing NF-κB pathway and reducing proinflammatory cytokines secretion (e.g., tumor necrosis factor-α, interleukin-1β, and interleukin-6); (3) inhibiting liver fibrosis and collagen deposition by regulating the expression of transforming growth factor-β and α-smooth muscle actin; (4) modulating abnormal bile acid metabolism through increasing the expression of bile salt export pump and multidrug resistance-associated protein 2. This study was the first to elucidate the potential preventive effect of RCM extracts on DDC-induced cholestasis in mice from multiple pathways, which suggested that RCM fruits could be considered as a potential dietary supplement to prevent cholestasis.

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Preventive effect of ethanol extract from Chinese sumac fruits against tetrachloromethane-induced liver fibrosis in mice

Abstract: Chinese sumac (Rhus chinensis Mill.) fruits are traditionally used as a condiment and herb. The aim of this study was to evaluate the prevention of ethanol extract from Chinese sumac...

Cited by 21 publications

References 33 publications

Anti‐Diabetic Effects of Different Phenolic‐Rich Fractions from Rhus Chinensis Mill. Fruits in vitro

Anti‐Diabetic Effects of Different Phenolic‐Rich Fractions from Rhus Chinensis Mill. Fruits in vitro

Integrating Network Pharmacology and Experimental Validation to Investigate the Effects and Mechanism of Astragalus Flavonoids Against Hepatic Fibrosis

Protective Effect of Rhus chinensis Mill. Fruits on 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine-Induced Cholestasis in Mice via Ameliorating Oxidative Stress and Inflammation

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