Previous outpatient antibiotic use in patients admitted to hospital for COPD exacerbations: room for improvement

Miravitlles, Marc; Soler-Cataluña, Juan José; Baranda, F.; Greses, J.V.; Roza, Cristian de la

doi:10.1007/s15010-012-0316-8

Cited by 4 publications

(2 citation statements)

References 43 publications

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“…Hospitalizations have important social and economic implications as well (18). By the way, a low rate of previous antibiotic use among patients with a COPD exacerbation requiring hospital admission has been reported in the literature (19); therefore, our study population seems once again of interesting originality.…”

Section: Discussionmentioning

confidence: 85%

Prulifloxacin vs Levofloxacin for Exacerbation of COPD after Failure of Other Antibiotics

Giusti

Blasi

Iori³

et al. 2016

COPD: Journal of Chronic Obstructive Pulmonary Disease

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The chronic course and evolution of chronic obstructive pulmonary disease (COPD) is often characterized by periods of exacerbation of symptoms, which have a negative impact on the quality of life of patients, as well as on the evolution of COPD, and represent a significant cause of medical intervention and hospitalization. Very few data are available on the efficacy of rescue antibiotics in patients with acute exacerbation of COPD (AECOPD) unresponsive to previous treatment. The aim of this study was to evaluate the efficacy of two fluoroquinolones in AECOPD previously treated without success. The FADOI-FLOR study is a randomized, single-blind, non-inferiority comparison between levofloxacin and prulifloxacin. Primary end-point was "therapeutic success" at Day 10 of treatment, defined as disappearance of signs/symptoms or decrease of at least three points of a global score of symptomatology (maximum score = 15). 258 patients were enrolled (128 levofloxacin and 130 prulifloxacin), in 25 centers. A very high proportion of patients in the two groups had therapeutic success at Day-10 (levofloxacin 93.0% vs prulifloxacin 96.7%, population intention-to-treat; 94.6% vs 99.1%, population per-protocol). Earlier therapeutic success (within 7 days) was achieved in 32.0% and 36.2% of patients receiving levofloxacin or prulifloxacin, respectively. At 3-month follow-up, re-exacerbations occurred in 17.8% of patients treated with levofloxacin and 14.2% of those receiving prulifloxacin (p = 0.44). In conclusion, fluoroquinolones are very effective in the treatment of AECOPD resistant to other antibiotics.

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Section: Discussionmentioning

confidence: 85%

Prulifloxacin vs Levofloxacin for Exacerbation of COPD after Failure of Other Antibiotics

Giusti

Blasi

Iori³

et al. 2016

COPD: Journal of Chronic Obstructive Pulmonary Disease

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show abstract

“…In the past, long-term administration of antibiotics was used to treat acute exacerbations of COPD, but metaanalyses of the studies of antibiotic administration showed no significant benefit (2). A multicenter, crosssectional, observational study was conducted in 30 Spanish hospitals among COPD patients aged > 40 years who were hospitalized for an acute exacerbation showed that antibiotic use was significantly associated with yellow or green-yellow sputum prior to the exacerbation, a higher number of exacerbations in the previous year, more visits to emergency departments, and bronchiectasis (3). Because of these problems with antibiotic treatment, more and more traditional Chinese physicians are focusing on exploring the therapeutic effect of Chinese herbal medicine in COPD.…”

Section: Introductionmentioning

confidence: 99%

Effects of Xiaoqinglong decoction on gene expression profiles in a rat chronic obstructive pulmonary disease model

Zhang

et al. 2012

Biosci Trends

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Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Weiden¹,

Horowitz²

2015

Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases

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Previous outpatient antibiotic use in patients admitted to hospital for COPD exacerbations: room for improvement

Abstract: This study demonstrates a low rate of previous outpatient treatment and antibiotic use among patients with a COPD exacerbation requiring hospital admission.

Cited by 4 publications

References 43 publications

Prulifloxacin vs Levofloxacin for Exacerbation of COPD after Failure of Other Antibiotics

Prulifloxacin vs Levofloxacin for Exacerbation of COPD after Failure of Other Antibiotics

Effects of Xiaoqinglong decoction on gene expression profiles in a rat chronic obstructive pulmonary disease model

Acute Exacerbations of Chronic Obstructive Pulmonary Disease

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