Prmt1 upregulated by Hdc deficiency aggravates acute myocardial infarction via NETosis

Zhang, Zhiwei; Ding, Saidan; Wang, Zhe; Zhu, Xiaowei; Zhou, Zheliang; Zhang, Weiwei; Yang, Xiangdong; Ge, Junbo

doi:10.1016/j.apsb.2021.10.016

Cited by 22 publications

(10 citation statements)

References 71 publications

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“…Protein arginine methylation, which is catalyzed by protein arginine methyltransferases (PRMTs), is one of the most common PTMs. These PRMTs regulate a broad array of cellular processes and are increasingly being recognized as drivers for human diseases, including cancer 5 , 6 , 7 . Numerous studies showed that several metabolic enzymes are methylated by PRMTs.…”

Section: Introductionmentioning

confidence: 99%

PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism

Sun

Niu

et al. 2023

Acta Pharmaceutica Sinica B

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Section: Introductionmentioning

confidence: 99%

PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism

Sun

Niu

et al. 2023

Acta Pharmaceutica Sinica B

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“…Therefore, validation with different species is needed to further expand the implications of this experiment. The low-level active components of Saussurea involucrata are also worthy of exploration, which requires more sensitive analysis methods and more in-depth metabolic research, and with the study of cardiovascular diseases and gut microbiota [70][71][72][73][74], more targets and mechanism of Saussurea involucrata will be found.…”

Section: Discussionmentioning

confidence: 99%

Metabolites Analysis of Anti-Myocardial Ischemia Active Components of Saussurea involucrata Based on Gut Microbiota—Drug Interaction

Guo

et al. 2022

IJMS

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Saussurea involucrata has been reported to have potential therapeutic effects against myocardial ischemia. The pharmacological effects of oral natural medicines may be influenced by the participation of gut microbiota. In this study, we aimed to investigate the bidirectional regulation of gut microbiota and the main components of Saussurea involucrata. We first established a quantitative method for the four main components (chlorogenic acid, syringin, acanthoside B, rutin) which were chosen by fingerprint using liquid chromatography tandem mass spectrometry (LC-MS/MS), and found that gut microbiota has a strong metabolic effect on them. Meanwhile, we identified five major rat gut microbiota metabolites (M1–M5) using liquid chromatography tandem time-of-flight mass spectrometry (LC/MSn-IT-TOF). The metabolic properties of metabolites in vitro were preliminarily elucidated by LC-MS/MS for the first time. These five metabolites of Saussurea involucrata may all have potential contributions to the treatment of myocardial ischemia. Furthermore, the four main components (10 μg/mL) can significantly stimulate intestinal bacteria to produce short chain fatty acids in vitro, respectively, which can further contribute to the effect in myocardial ischemia. In this study, the therapeutic effect against myocardial ischemia of Saussurea involucrata was first reported to be related to the intestinal flora, which can be useful in understanding the effective substances of Saussurea involucrata.

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“…Regarding MI, studies have found that HDC is associated with ROS and myeloid cell differentiation. Zhang et al investigated the effect of HDC on ROS production in neutrophils with PMA treatment and observed that the level of ROS produced by neutrophils in the absence of HDC was significantly higher than that in the HDC group, irrespective of PMA treatment [ 51 ] Moreover, previous studies have demonstrated that excess ROS promotes NET production, thus highlighting that HDC plays a crucial role in regulating neutrophils function, especially cellular activity. Additionally, NETs isolated from HDC bone marrow were co-cultured with cardiomyocytes under hypoxic conditions for 24 h after PMA activation and revealed that HDC-deficient neutrophils caused more cardiomyocyte-related death than controls.…”

Section: Nets In Acsmentioning

confidence: 99%

“…In conclusion, neutrophils are recruited to the ischemic injury site of the myocardium when MI occurs, wherein point HDC deficiency leads to attenuated neutrophil adhesion but enhanced migration. Furthermore, PRMT1 increases the production of ROS and NETs through the H1R-SWI/SNF-PRMT1-ROS pathway [ 51 ], which in turn promotes cardiomyocyte death and cardiac fibroblast proliferation, ultimately leading to the aggravation of MI.…”

Section: Nets In Acsmentioning

confidence: 99%

Neutrophil extracellular traps in acute coronary syndrome

Wei

et al. 2023

J Inflamm

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Acute coronary syndrome (ACS) is a group of clinical syndromes caused by acute myocardial ischemia, which can cause heart failure, arrhythmia and even sudden death. It is the major cause of disability and death worldwide. Neutrophil extracellular traps (NETs) are reticular structures released by neutrophils activation and have various biological functions. NETs are closely related to the occurrence and development of ACS and also the subsequent damage after myocardial infarction. The mechanisms are complex and interdependent on various pathways, which require further exploration. This article reviewed the role and mechanism of NETs in ACS, thereby providing a valuable reference for the diagnosis and clinical treatment of ACS.

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Prmt1 upregulated by Hdc deficiency aggravates acute myocardial infarction via NETosis

Cited by 22 publications

References 71 publications

PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism

PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism

Metabolites Analysis of Anti-Myocardial Ischemia Active Components of Saussurea involucrata Based on Gut Microbiota—Drug Interaction

Neutrophil extracellular traps in acute coronary syndrome

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