Process Analytical Chemistry—Application of Mass Spectrometry in Environmental Analysis: An Overview

Llamas, Álvaro; Ojeda, C. Bosch; Rojas, F. Sánchez

doi:10.1080/05704920701293810

Cited by 10 publications

(5 citation statements)

References 214 publications

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“…Several reviews describe MIMS research trends, [3] its environmental applications [4] and its role in process analytical chemistry. [5] MIMS is thus a part of a recent wave of MS-based techniques that minimize sample preparation and make it possible to carry out direct on-line analysis in complex samples. The overall mass transfer of analyte across a semi-permeable membrane, on the molecular level, involves partitioning into the membrane material, diffusion through the membrane, and partitioning out of the membrane at the opposite surface.…”

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confidence: 99%

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Characterization of a condensed‐phase membrane introduction mass spectrometry (CP‐MIMS) interface using a methanol acceptor phase coupled with electrospray ionization for the continuous on‐line quantitation of polar, low‐volatility analytes at trace levels in complex aqueous samples

Duncan

McCauley

Krogh

et al. 2011

Rapid Comm Mass Spectrometry

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We report the development and application of a capillary hollow fibre membrane interface using methanol as an acceptor phase to deliver target analytes to an electrospray ionization source and a triple quadrupole mass spectrometer. Superior fluid handling systems lead to greater signal stability and membrane integrity for the continuous on-line monitoring of polar and charged analytes in complex aqueous samples with detection limits in the parts-per-trillion to parts-per-billion range. The system can be operated in either a continuous flow or a stopped acceptor flow mode - the latter giving rise to greater sensitivity. We report detection limits, enrichment factors and signal response times for selected analytes with polydimethylsiloxane and Nafion® polymer membrane interfaces. In addition, we demonstrate the use of this interface to detect pharmaceuticals and other contaminants in natural water and artificial urine. The improved sensitivity and analytical response times of our CP-MIMS system make it possible to continuously monitor dynamic chemical systems with temporal resolutions on the order of minutes. Presented is a comparison of the performance of CP-MIMS versus direct infusion electrospray ionization, demonstrating the potential advantages over direct infusion for trace analyte measurements in complex, high ionic strength samples. Furthermore, by continuously flowing a reaction mixture in a closed loop over the interface, we demonstrate the use of the system as an in situ reaction-monitoring platform for the chlorination of a model organic compound in aqueous solution.

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confidence: 99%

Characterization of a condensed‐phase membrane introduction mass spectrometry (CP‐MIMS) interface using a methanol acceptor phase coupled with electrospray ionization for the continuous on‐line quantitation of polar, low‐volatility analytes at trace levels in complex aqueous samples

Duncan

McCauley

Krogh

et al. 2011

Rapid Comm Mass Spectrometry

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“…Calibration for quantitative analysis is achieved by measurement of calibration gases, which can be readily purchased. Advancements in MS instrumentation have been reviewed, 43 emphasizing the miniaturization that has been achieved, thus making available fi eldportable mass spectrometers.…”

Section: Mass S Pectrometrymentioning

confidence: 99%

Future Trends for PAT for Increased Process Understanding and Growing Applications in Biomanufacturing

Bakeev¹,

Menezes²

2010

Process Analytical Technology

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“…Mass spectrometry has been widely employed for detection of environmental pollutants, illegal drugs, and explosives for its rapid, high sensitivity, and accuracy in qualitative analysis [ 1 ]. However, traditional mass spectrometry used in lab can barely be applied for in situ detection due to its size and weight.…”

Section: Introductionmentioning

confidence: 99%

Development of a Portable Single Photon Ionization-Photoelectron Ionization Time-of-Flight Mass Spectrometer

Huang

Tang

et al. 2015

International Journal of Analytical Chemistry

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A vacuum ultraviolet lamp based single photon ionization- (SPI-) photoelectron ionization (PEI) portable reflecting time-of-flight mass spectrometer (TOFMS) was designed for online monitoring gas samples. It has a dual mode ionization source: SPI for analyte with ionization energy (IE) below 10.6 eV and PEI for IE higher than 10.6 eV. Two kinds of sampling inlets, a capillary inlet and a membrane inlet, are utilized for high concentration and trace volatile organic compounds, respectively. A mass resolution of 1100 at m/z 64 has been obtained with a total size of 40 × 31 × 29 cm, the weight is 27 kg, and the power consumption is only 70 W. A mixture of benzene, toluene, and xylene (BTX), SO2, and discharging products of SF6 were used to test its performance, and the result showed that the limit of quantitation for BTX is as low as 5 ppbv (S/N = 10 : 1) with linear dynamic ranges greater than four orders of magnitude. The portable TOFMS was also evaluated by analyzing volatile organic compounds from wine and decomposition products of SF6 inside of a gas-insulated switchgear.

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Process Analytical Chemistry—Application of Mass Spectrometry in Environmental Analysis: An Overview

Cited by 10 publications

References 214 publications

Characterization of a condensed‐phase membrane introduction mass spectrometry (CP‐MIMS) interface using a methanol acceptor phase coupled with electrospray ionization for the continuous on‐line quantitation of polar, low‐volatility analytes at trace levels in complex aqueous samples

Characterization of a condensed‐phase membrane introduction mass spectrometry (CP‐MIMS) interface using a methanol acceptor phase coupled with electrospray ionization for the continuous on‐line quantitation of polar, low‐volatility analytes at trace levels in complex aqueous samples

Future Trends for PAT for Increased Process Understanding and Growing Applications in Biomanufacturing

Development of a Portable Single Photon Ionization-Photoelectron Ionization Time-of-Flight Mass Spectrometer

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