Professor Christopher J. Moody

ChemInform Abstract: Pyridazine‐Fused Carbazoles: Synthesis, Reactivity, and Antitumor Activity.

“…Vol. 39 1,4-dimethyl-2,3-carbazolediester [15] under the same conditions gives a five-membered cyclization product, i.e,. the N-aminoimide 8 (Scheme 3) [16].…”

Synthesis of Ellipticine by Hetaryne Cycloadditions − Control of Regioselectivity

“…LiHMDS (0.125 , 6.3 mL, 0.79 mmol) was slowly added to a solution of 8a [41] (140 mg, 0.66 mmol) in dry THF (15 mL) at Ϫ20°C. After this had been heated for 20 min, PhSO 2 Cl (0.14 mL, 1.05 mmol) was added and the mixture was stirred overnight at Ϫ20°C.…”

“…Pyrone 8a [41] (36 mg, 0.169 mmol), CsF (300 mg, 1.98 mmol), and 12a (565 mg, 1.70 mmol) in CH 3 CN (3 mL) gave a 1:1 mixture of adducts 19a and 20a (10 mg, 21%) after chromatography (silica gel; CH 2 Cl 2 /EtOAc, 19:1). (14).…”

One-pot reaction of pyranoindolones with phenylisocyanates: a simple and regioselective approach to β-carbolines

“…26,27 Diels-Alder reactions of pyranoindolones with dienophiles are often employed as a key reaction for the synthesis of fused carbazoles 28,29 e.g., access to the alkaloids carbazomycins A and B. 30 Previously, we described synthetic methodologies towards the synthesis of b-carbolinones based on the reactions of pyranoindolones with phenylhydrazine or benzoylhydrazine 31 or utilizing N,N 0 -disubstituted ureas (PhBr, reflux) 32 (Scheme 1).…”