Profile of SGPT and SGOT on Male Rats (Rattus norvegicus) Hyperglycemic After Giving Insulin Leaf Extract (Tithonia diversifolia)

Abstract

The leaves of insulin (Tithonia diversifolia (Hemsl.) A. Gray) are native bush plants from Central America. This plant in Indonesia is often called paitan or kembang bulan. The aim of this research was to know the profile of SGPT and SGOT of male white rat (Rattus norvegicus L.) hyperglycemic after giving insulin leaf extract (Tithonia diversifolia (Hemsl.) A. Gray). This study used 20 male Wistar rats which were divided randomly into 5 groups of treatment. Those were P0 as a group of rats which was not given alloxan and insulin leaf extract, P1 as a group of rats which was given alloxan without insulin leaf extract, P2 as a group of rats which was given alloxan and glibenclamide 2 mg/Body Weight (BW)/day, P3 as a group of rats which was given alloxan and insulin leaf extract 30 mg/BW/day, P4 as a group of rats which was given alloxan and insulin leaf extract 60 mg/BW/day. Each treatment was repeated as many as 4 replications. The results of this study indicated that there was no significant differences in all variables, namely levels of SGPT, SGOT, liver weight, body weight and Hepatosomatic index (HSI), so it can be concluded that giving insulin leaf extract (Tithonia diversifolia (Hemsl.) A. Gray) of 30 mg/BW/day and 60 mg/BW/day could improve liver function of hyperglycemic male white rats (R. norvegicus L.).

An evaluation of pharmacological healing potentialities of Terminalia Arjuna against several ailments on experimental rat models with an in-silico approach

“…In Figure 1 , a significant elevation of body weight was observed after administering T. arjuna extract in alloxan-induced diabetic rats. A similar result was observed after administering Aloe megalacantha Baker extract, Sigesbeckiaorientalis, Panicum maximum, Anacardium occidentale L, Ricinuscommunis, Chloroxylonswietenia, Perseaamericana, and Tithoniadiversifolia [ 44 , 45 , 46 , 47 , 48 , 49 ] but, T. arjuna extract was observed to show a better result than Calpurnia aurea leaves [ 50 ].…”

Anadara granosa shell powder improves the metabolism, testosterone level, and sound frequency of Pelung chickens

“…If there was a significant difference among them, the Duncan test was then conducted for pairwise comparisons. The analysis was conducted using SPSS software, version 15 [ 22 ].…”

The Histomorphometry of Liver and Kidney of Hyperglycemic Albino Rats after Treatment with Tithonia diversifolia Leaf Extract

“…Hyperglycemia in rats is a condition of rat blood glucose of more than 126 mg/dL (Zubaidah et al, 2017). The animals were randomly divided into 5 treatment groups, there were T 0 (rat normal/control), T 1 (hyperglycemic rat without T. diversifolia leaf extract), T 2 (hyperglycemic rat administered with 10 mg/kg BW of Glibenclamide), T 3 (hyperglycemic rat administered with 150 mg/kg BW of T. diversifolia leaf extract), T 4 (hyperglycemic rat administered with 300 mg/kg BW of T. diversifolia leaf extract) (Yuneldi et al, 2018;Sari et al, 2018). Each treatment was repeated 4 times.…”

“…The other treatment was Glibenclamide 10 mg/kg BW. All treatment was done orally for 28 days (Yuneldi et al, 2018). The Ethics Committee of the Faculty of Medicine, Universitas Diponegoro approved all procedures.…”

“…The research on T. diversifolia has been conducted by Sari et al (2018), that showed that administration of 150 mg/kg BW and 300 mg/kg BW for T. diversifolia leaf extract 28 days can reduce blood glucose levels in hyperglycemic rats. According to Yuneldi et al (2018), giving T. diversifolia 30 mg/BW/day and 60 mg/BW/day for 28 days can improve rat liver function. Fakunle and Abatan (2007), reported that T. diversifolia leaf extract at a dose of 400 mg/kg BW for 14 days caused degeneration to necrosis in the liver and kidneys.…”