Programmable Biopolymers for Advancing Biomedical Applications of Fluorescent Nanodiamonds

Wu, Yuzhou; Ermakova, Anna; Liu, Weina; Pramanik, Goutam; Vu, Tran Minh; Kurz, Andrea; McGuinness, Liam P.; Naydenov, Boris; Hafner, Susanne; Reuter, Rolf; Wrachtrup, Joerg; Isoya, Junichi; Förtsch, Christina; Barth, Holger; Simmet, Thomas; Jelezko, Fedor; Weil, Tanja

doi:10.1002/adfm.201502704

Cited by 89 publications

(126 citation statements)

References 60 publications

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“…DNA, as well as drug transport and release of polycationic QDs and NDs into cells has been visualized by confocal imaging, which, in principle, offers monitoring of the entire gene delivery pathway inside cells. 357,715 …”

Section: In Vivo Combination Of Diagnosis and Treatment (“Theranostics”)mentioning

confidence: 99%

Diverse Applications of Nanomedicine

Pelaz¹,

et al. 2017

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The design and use of materials in the nanoscale size range for addressing medical and health-related issues continues to receive increasing interest. Research in nanomedicine spans a multitude of areas, including drug delivery, vaccine development, antibacterial, diagnosis and imaging tools, wearable devices, implants, high-throughput screening platforms, etc. using biological, nonbiological, biomimetic, or hybrid materials. Many of these developments are starting to be translated into viable clinical products. Here, we provide an overview of recent developments in nanomedicine and highlight the current challenges and upcoming opportunities for the field and translation to the clinic.

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Section: In Vivo Combination Of Diagnosis and Treatment (“Theranostics”)mentioning

confidence: 99%

Diverse Applications of Nanomedicine

Pelaz¹,

et al. 2017

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“…[166] Av ariety of functionalities can be introduced into the protein bioadhesive by chemical modification, for example, drug molecules,D NA,p olymers,o ri maging groups (Figure 13 c). [167] During protein coating, these functionalities are transferred to the nanoparticle surface,w hich results in efficient drug transporters or nanotheranostics for cancer therapy. [167b] Moreover,a dditional stabilization could be achieved by the introduction of appropriate chemical functional groups to confer better interactions with the nanoparticles.O ne could envision engineered multifunctional nanoparticle interfaces based on proteins encoded with defined structural information as ac onvenient platform to address specific biological challenges.…”

Section: Denatured Protein Coatings For Drug Delivery and Theranosticsmentioning

confidence: 99%

Engineering Proteins at Interfaces: From Complementary Characterization to Material Surfaces with Designed Functions

et al. 2018

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Once materials come into contact with a biological fluid containing proteins, proteins are generally-whether desired or not-attracted by the material's surface and adsorb onto it. The aim of this Review is to give an overview of the most commonly used characterization methods employed to gain a better understanding of the adsorption processes on either planar or curved surfaces. We continue to illustrate the benefit of combining different methods to different surface geometries of the material. The thus obtained insight ideally paves the way for engineering functional materials that interact with proteins in a predetermined manner.

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“…Wu et al chemically modified HSA with ethylenediamine for covalent conjugation with polyethylene glycol (PEG) and the anticancer drug doxorubicin (DOX). The positively charged HSA‐based biopolymers were then physically attached to the negatively charged FND surface . They reported that the nanohybrids have excellent colloidal stability, high biocompatibility, and cellular uptake, as well as effective release of DOX from the carriers in A549 cells.…”

Section: Biohybrid Fndsmentioning

confidence: 99%

Biohybrid fluorescent nanodiamonds as dual‐contrast markers for light and electron microscopies

Sotoma

Hsieh

Chang

2018

J Chinese Chemical Soc

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Cathodoluminescence (CL) and correlative light‐electron microscopy (CLEM) are two useful analytical tools in diverse research areas. Recently, fluorescent nanodiamonds (FNDs) have emerged as promising imaging agents for both CL and CLEM owing to their exceptional photophysical and chemical properties. However, to realize their practical applications in the life sciences, surface modification and functionalization of the nanomaterials with bioactive molecules are critical and essential. Here we provide a comprehensive review on the methods of synthesizing biohybrid FNDs as well as recent advances of CL and CLEM imaging of cells with these carbon nanoparticles as dual‐contrast markers.

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Programmable Biopolymers for Advancing Biomedical Applications of Fluorescent Nanodiamonds

Cited by 89 publications

References 60 publications

Diverse Applications of Nanomedicine

Diverse Applications of Nanomedicine

Engineering Proteins at Interfaces: From Complementary Characterization to Material Surfaces with Designed Functions

Biohybrid fluorescent nanodiamonds as dual‐contrast markers for light and electron microscopies

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