Prokinetic effect of black tea on gastrointestinal motility

Chaudhuri, Lalima; Basu, Sandip K.; Seth, Pallab; Chaudhuri, T. C.; Besra, Shila Elizabeth; Vedasiromoni, J. R.; Ganguly, Dilip

doi:10.1016/s0024-3205(99)00657-8

Cited by 27 publications

(26 citation statements)

References 19 publications

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“…b Denotes significant increase from loperamide (p < 0.05). The results on the effect of BTE (3% and 6%) on UGT in mice support the earlier findings that a single administration of a 3% solution of BTE increased UGT (Chaudhuri et al , 2000). It has been suggested that the thearubigin fraction (but not theaflavin) is responsible for the increase in UGT caused by BTE (Chaudhuri et al , 2000).…”

Section: Discussionsupporting

confidence: 87%

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Antidiarrhoeal activity of hot water extract of black tea (Camellia sinensis)

Besra

Gomes

Ganguly

et al. 2003

Phytotherapy Research

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The effect of a hot water extract of black tea (Camellia sinensis (L.) O. Kuntze, Theaceae) on upper gastrointestinal transit and on diarrhoea was investigated employing conventional rodent models of diarrhoea. Black tea extract was found to possess antidiarrhoeal activity in all the models of diarrhoea used. Naloxone (0.5 mg/kg i.p.) significantly inhibited the antidiarrhoeal activity of the extract as well as loperamide, thus indicating a role of the opioid system in the antidiarrhoeal activity of the extract.

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Section: Discussionsupporting

confidence: 87%

“…Recent reports from this laboratory indicate that while single administration of a 3% solution of BTE increased gastric transit (Chaudhuri et al ., 2000), chronic administration of a higher concentration of BTE, i.e. 10% solution failed to increase gastric transit (Maity et al , 2001).…”

Section: Introductionmentioning

confidence: 98%

Antidiarrhoeal activity of hot water extract of black tea (Camellia sinensis)

Besra

Gomes

Ganguly

et al. 2003

Phytotherapy Research

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“…The marked reduction in both intestinal transit and gastric emptying observed in all the three ulcerogentreated rats support the suggestion that gastrointestinal motility is involved in the pathogenesis of gastric lesions (28,29). In an earlier report from this laboratory, single administration of a 3% solution of BTE was found to increase gastric transit (30). The failure of BTE in the present study to increase gastric transit may be due to the higher concentration; i.e., 10% solution of BTE administered chronically (once daily for 7 days).…”

Section: Discussionsupporting

confidence: 84%

“…The NO synthesis inhibitors used in the present study are usually considered to inhibit specifically the enzymes that generate NO in peripheral tissues (31) and in the central nervous system (32). In an earlier study, it was reported that L-NMMA increased gastric transit significantly (30). The failure of L-NMMA and L-NAME to reverse the ulcerogen induced decrease in gastric transit in the present study may be due to the higher dose; i.e., 25 mg / kg in our study as against 500 mg/ kg used in the previous study.…”

Section: Discussionmentioning

confidence: 98%

Role of Reduced Glutathione and Nitric Oxide in the Black Tea Extract-Mediated Protection Against Ulcerogen-Induced Changes in Motility and Gastric Emptying in Rats

Maity

Vedasiromoni

Chaudhuri

et al. 2001

Japanese Journal of Pharmacology

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ABSTRACT-The aim of the present study was to investigate the underlying mechanism of the role of hot water extract of black tea [Camellia sinensis (L). O. Kuntze Theaceae] in normalizing the changes in intestinal transit and gastric emptying induced by various ulcerogenic agents in experimental rats. Intestinal transit as well as gastric emptying were significantly reduced in rats treated with glutathione (GSH) depleting agents, diethyl maleate (DEM), indoacetamide (IDA) and N-ethyl maleimide (NEM). Prior oral administration of black tea extract (BTE) at 20 ml / kg of a 10% solution, i.g. once a day for 7 days significantly increased the intestinal transit and gastric emptying with restoration of serum GSH level. Singular administration of succimer (60 mg/ kg, i.g.), the standard sulfhydryl containing antiulcer agent used as a reference drug, was also effective. Increase in intestinal transit caused by BTE was reversed both by N-omega-nitro-L-arginine methyl ester (L-NAME) (25 mg/ kg, i.p.) and N-omega-monomethyl-L-arginine (L-NMMA) (25 mg/ kg, i.p.), but not with N-omega-nitro-D-arginine methyl ester (D-NAME) (25 mg/ kg, i.p.). Furthermore, restoration of intestinal nitric oxide synthase (NOS) activity was found to be associated with BTE treatment. These results provide evidence that nitric oxide may play a role in BTE-mediated improvement of intestinal motility changes and gastric emptying induced by DEM, IDA and NEM.

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“…Curcumin, a polyphenolic from turmeric, reduced inflammation in a mouse model of colonic inflammation . Black tea has multiple effects on physical aspects of the intestinal barrier in that it can improve tight junction integrity and speed gastrointestinal transit (Chaudhuri et al, 2000;Hashimoto et al, 1997). Some polyunsaturated fatty acids (PUFAs) are able to decrease intestinal permeability (Vine et al, 2002) and reduce intestinal inflammation (Knoch et al, 2009).…”

Section: Foods That Enhance Intestinal Barrier Functionmentioning

confidence: 99%