Prolonged antifungal effects of clotrimazole-containing mucoadhesive thermosensitive gels on vaginitis

Chang, Jung Yun; Oh, Yu‐Kyoung; Kong, Hak Soo; Kim, Eun Jung; Jang, Dong Deuk; Nam, Ki Taek; Kim, Chong Kook

doi:10.1016/s0168-3659(02)00086-x

Cited by 149 publications

(67 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In particular, topical antifungal therapy is 39 preferred due to the systemic toxicity of antifungal drugs (Chang et al, 2002). In pregnant 40 patients, the two main therapy goals can be summarized as i) assuring the high local drug 41 concentration with concomitant avoidance of systemic absorption and ii) prevention of 42 infection recurrence (Vanić and Škalko-Basnet, 2013).…”

Section: Introduction 37mentioning

confidence: 99%

Chitosan-coated liposomes for topical vaginal therapy: Assuring localized drug effect

Jøraholmen

Vanić

Tho

et al. 2014

International Journal of Pharmaceutics

View full text Add to dashboard Cite

16The choice of drug therapy in pregnant patients suffering from vaginal infections is limited 17 by the safety profile of the drug. Assuring the efficient topical therapy to avoid systemic 18 absorption is considered the best therapy option. Chitosan-coated liposomes have been 19 developed and optimized to assure localized therapy of clotrimazole. Chitosan was selected 20 as mucoadhesive polymer both to prolong system's retention at the vaginal site and act on 21 biofilms responsible for high recurrence of infections. Sonicated liposomes were coated 22 with chitosan in three different concentrations, namely 0.1, 0.3 and 0.6 % (w/v).

show abstract

Section: Introduction 37mentioning

confidence: 99%

Chitosan-coated liposomes for topical vaginal therapy: Assuring localized drug effect

Jøraholmen

Vanić

Tho

et al. 2014

International Journal of Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…Chang Yun et al (2002 fabricated Clotrimazole-loaded cyclodextrin complex by using combination of poloxamers (P) 407, 188, and polycarbophil (PC). The results showed that controlled release of drug was achieved and exhibit excellent in-vivo anti-fungal activity in female rats (Yun Chang et al, 2002).…”

Section: Polycarbophilmentioning

confidence: 94%

“…Hydroxypropyl-b-cyclodextrin complex was reported to increase solubility of Amphotericin B; when both were formulated as thermo-sensitive, pH-sensitive gel, controlled release was successfully achieved. Cyclodextrin complexes were also successfully employed in anti-viral therapy to deliver anti-HIV agents (Yang et al, 2008). Chang Yun et al (2002 fabricated Clotrimazole-loaded cyclodextrin complex by using combination of poloxamers (P) 407, 188, and polycarbophil (PC).…”

Section: Polycarbophilmentioning

confidence: 99%

Advanced topical drug delivery system for the management of vaginal candidiasis

et al. 2014

View full text Add to dashboard Cite

Vaginal candidiasis or vulvovaginal candidiasis (VC) is a common mucosal infection of vagina, mainly caused by Candida species. The major symptoms of VC are dyspareunia, pruritis, itching, soreness, vagina as well as vulvar erythema and edema. Most common risk factors that lead to the imbalance in the vaginal micro biota are the use of antibiotics, pregnancy, diabetes mellitus, immuno suppression as in AIDS or HIV patients, frequent sexual intercourse, spermicide and intra-uterine devices and vaginal douching. Various anti-fungal drugs are available for effective treatment of VC. Different conventional vaginal formulations (creams, gels, suppositories, powder, ointment, etc.) for VC are available today but have limited efficacy because of lesser residence time on vaginal epithelium due to self-cleansing action of vagina. So to overcome this problem, an extended and intimate contact with vaginal mucosa is desired; which can be accomplished by utilizing mucoadhesive polymers. Mucoadhesive polymers have an excellent binding capacity to mucosal tissues for considerable period of time. This unique property of these polymers significantly enhances retention time of different formulations on mucosal tissues. Currently, various novel formulations such as liposomes, nano-and microparticles, micro-emulsions, bio-adhesive gel and tablets are used to control and treat VC. In this review, we focused on current status of vaginal candidiasis, conventional and nanotechnology inspired formulation approaches.

show abstract

“…NMP could dissolve a large amount of the polymer, thus controlling both drug diffusion and easiness of syringeability. 27 The main critical parameters of depot formation or structure change to form a gel were both temperature increase to 37°C and water diffusion rate into the Zein nanoparticlesloaded triblock polymer. The diffusion rate of the aqueous phosphate buffer pH 7.2 into the polymeric solutions decreased with increasing the triblock polymer concentration (P,0.05; Figure 5) due to the increased gel viscosity.…”

Section: Characterization Of the Prepared In Situ Gelsmentioning

confidence: 99%

Mechanistic analysis of Zein nanoparticles/PLGA triblock in situ forming implants for glimepiride

Ahmed¹,

Zidan²,

Khayat³

2016

IJN

View full text Add to dashboard Cite

Objectives The study aims at applying pharmaceutical nanotechnology and D-optimal fractional factorial design to screen and optimize the high-risk variables affecting the performance of a complex drug delivery system consisting of glimepiride–Zein nanoparticles and inclusion of the optimized formula with thermoresponsive triblock copolymers in in situ gel. Methods Sixteen nanoparticle formulations were prepared by liquid–liquid phase separation method according to the D-optimal fractional factorial design encompassing five variables at two levels. The responses investigated were glimepiride entrapment capacity (EC), particle size and size distribution, zeta potential, and in vitro drug release from the prepared nanoparticles. Furthermore, the feasibility of embedding the optimized Zein-based glimepiride nanoparticles within thermoresponsive triblock copolymers poly(lactide- co -glycolide)-block-poly(ethylene glycol)-block-poly(lactide- co -glycolide) in in situ gel was evaluated for controlling glimepiride release rate. Results Through the systematic optimization phase, improvement of glimepiride EC of 33.6%, nanoparticle size of 120.9 nm with a skewness value of 0.2, zeta potential of 11.1 mV, and sustained release features of 3.3% and 17.3% drug released after 2 and 24 hours, respectively, were obtained. These desirability functions were obtained at Zein and glimepiride loadings of 50 and 75 mg, respectively, utilizing didodecyldimethylammonium bromide as a stabilizer at 0.1% and 90% ethanol as a common solvent. Moreover, incorporating this optimized formulation in triblock copolymers-based in situ gel demonstrated pseudoplastic behavior with reduction of drug release rate as the concentration of polymer increased. Conclusion This approach to control the release of glimepiride using Zein nanoparticles/triblock copolymers-based in situ gel forming intramuscular implants could be useful for improving diabetes treatment effectiveness.

show abstract

Prolonged antifungal effects of clotrimazole-containing mucoadhesive thermosensitive gels on vaginitis

Cited by 149 publications

References 17 publications

Chitosan-coated liposomes for topical vaginal therapy: Assuring localized drug effect

Chitosan-coated liposomes for topical vaginal therapy: Assuring localized drug effect

Advanced topical drug delivery system for the management of vaginal candidiasis

Mechanistic analysis of Zein nanoparticles/PLGA triblock in situ forming implants for glimepiride

Contact Info

Product

Resources

About