Prolonged impact of a one-week course of clindamycin on Enterococcus spp. in human normal microbiota

Lindgren, Marianne; Löfmark, Sonja; Edlund, Charlotta; Huovinen, Pentti; Jalava, Jari

doi:10.1080/00365540802651897

Cited by 25 publications

(18 citation statements)

References 23 publications

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“…Several studies have shown the adverse effects of different antibiotics on the host gut microbiota in both human subjects (54,58,135,171,304) and animal models (8,51,272,344). The aftermath of antibiotic administration often lasts for a long time after discontinuation of treatment (51,58,135,167,171), suggesting that a prolonged dysfunction is induced in the host's microbial "organ. "…”

Section: A Imbalance Leads To Chaosmentioning

confidence: 99%

Gut Microbiota in Health and Disease

Sekirov

Russell

Antunes

et al. 2010

Physiological Reviews

3,526

2,609

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Gut microbiota is an assortment of microorganisms inhabiting the length and width of the mammalian gastrointestinal tract. The composition of this microbial community is host specific, evolving throughout an individual's lifetime and susceptible to both exogenous and endogenous modifications. Recent renewed interest in the structure and function of this "organ" has illuminated its central position in health and disease. The microbiota is intimately involved in numerous aspects of normal host physiology, from nutritional status to behavior and stress response. Additionally, they can be a central or a contributing cause of many diseases, affecting both near and far organ systems. The overall balance in the composition of the gut microbial community, as well as the presence or absence of key species capable of effecting specific responses, is important in ensuring homeostasis or lack thereof at the intestinal mucosa and beyond. The mechanisms through which microbiota exerts its beneficial or detrimental influences remain largely undefined, but include elaboration of signaling molecules and recognition of bacterial epitopes by both intestinal epithelial and mucosal immune cells. The advances in modeling and analysis of gut microbiota will further our knowledge of their role in health and disease, allowing customization of existing and future therapeutic and prophylactic modalities.

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Section: A Imbalance Leads To Chaosmentioning

confidence: 99%

Gut Microbiota in Health and Disease

Sekirov

Russell

Antunes

et al. 2010

Physiological Reviews

3,526

2,609

View full text Add to dashboard Cite

show abstract

“…In populations without underlying chronic diseases the selective pressure of prolonged antibiotic treatment can trigger a substantial reduction of metabolically important bacterial groups [1,2], favor selection of antimicrobial resistant strains [3] and decrease colonization resistance, eliciting overgrowth by potentially pathogenic microorganisms [4]. Moreover, several studies have reported a long-term post-treatment perturbation [5][6][7][8]. In young children, antibiotic-associated GI dysbiosis might have severe consequences for their quality of life by disturbing the maturation of the mucosa-associated lymphoid system [9][10][11][12] and inadequate immune development [13,14], thus increasing the risk for acquiring infections.…”

Section: Introductionmentioning

confidence: 99%

Dysbiosis of bifidobacteria and Clostridium cluster XIVa in the cystic fibrosis fecal microbiota

Duytschaever

Huys

Bekaert

et al. 2013

Journal of Cystic Fibrosis

114

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“…Shortterm changes in the quantity and composition of the bacteria comprising the normal human flora as a response to antibiotic exposure have been extensively recorded (for example Sullivan et al, 2001). However, only a few recent studies have investigated the long-term impacts of antibiotic administration, including development of resistance (Jakobsson et al, 2007;Jernberg et al, 2007;Lindgren et al, 2009;Löfmark et al, 2006;Nyberg et al, 2007;Sjölund et al, 2003).…”

Section: Impact Of Antibiotics On Normal Gut Microbiota Compositionmentioning

confidence: 99%

Long-term impacts of antibiotic exposure on the human intestinal microbiota

et al. 2010

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Although it is known that antibiotics have short-term impacts on the human microbiome, recent evidence demonstrates that the impacts of some antibiotics remain for extended periods of time. In addition, antibiotic-resistant strains can persist in the human host environment in the absence of selective pressure. Both molecular-and cultivation-based approaches have revealed ecological disturbances in the microbiota after antibiotic administration, in particular for specific members of the bacterial community that are susceptible or alternatively resistant to the antibiotic in question. A disturbing consequence of antibiotic treatment has been the long-term persistence of antibiotic resistance genes, for example in the human gut. These data warrant use of prudence in the administration of antibiotics that could aggravate the growing battle with emerging antibioticresistant pathogenic strains.

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Prolonged impact of a one-week course of clindamycin on Enterococcus spp. in human normal microbiota

Cited by 25 publications

References 23 publications

Gut Microbiota in Health and Disease

Gut Microbiota in Health and Disease

Dysbiosis of bifidobacteria and Clostridium cluster XIVa in the cystic fibrosis fecal microbiota

Long-term impacts of antibiotic exposure on the human intestinal microbiota

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