Prolonged iron depletion afterallogeneic 2‐unit RBC apheresis

Högler, Wolfgang; Mayer, W; Messmer, Christian; Eibl, Günther; Innerhofer, Petra; Schönitzer, Diether; Nußbaumer, Walter

doi:10.1046/j.1537-2995.2001.41050602.x

Cited by 21 publications

(20 citation statements)

References 15 publications

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“…It is well-known that blood donation depletes the donor of blood components, including a significant amount of iron in the RBCs (about 200-240 g) [28,29]. Indeed, several studies show that ferritin levels drop by about 50% after blood donation and that this effect worsens with frequent donation [30,31]. It has also been observed that a 4-month interval between donations is not sufficient to restore ferritin levels [31,32].…”

Section: Research Articlementioning

confidence: 99%

“…Indeed, several studies show that ferritin levels drop by about 50% after blood donation and that this effect worsens with frequent donation [30,31]. It has also been observed that a 4-month interval between donations is not sufficient to restore ferritin levels [31,32]. Thus, it is unlikely that the ferritin levels of the volunteers would have returned to baseline by the time the transfusion phase started (5 weeks after the blood donation).…”

Section: Research Articlementioning

confidence: 99%

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Hepcidin as a new biomarker for detecting autologous blood transfusion

et al. 2016

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Autologous blood transfusion (ABT) is an efficient way to increase sport performance. It is also the most challenging doping method to detect. At present, individual follow-up of haematological variables via the athlete biological passport (ABP) is used to detect it. Quantification of a novel hepatic peptide called hepcidin may be a new alternative to detect ABT. In this prospective clinical trial, healthy subjects received a saline injection for the control phase, after which they donated blood that was stored and then transfused 36 days later. The impact of ABT on hepcidin as well as haematological parameters, iron metabolism, and inflammation markers was investigated. Blood transfusion had a particularly marked effect on hepcidin concentrations compared to the other biomarkers, which included haematological variables. Hepcidin concentrations increased significantly: 12 hr and 1 day after blood reinfusion, these concentrations rose by seven-and fourfold, respectively. No significant change was observed in the control phase. Hepcidin quantification is a cost-effective strategy that could be used in an "ironomics" strategy to improve the detection of ABT.

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Section: Research Articlementioning

confidence: 99%

Section: Research Articlementioning

confidence: 99%

Hepcidin as a new biomarker for detecting autologous blood transfusion

et al. 2016

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“…Cardiovascular effects were minimal, but, while Hb had almost returned to the starting level at 16 weeks postdonation (Hb 14·4 ± 1·4 vs. 13·9 ± 1·3 g dL −1 ), ferritin levels remained altered (40 ± 24 vs. 18 ± 10 ng mL −1 ), as did mean plasma iron and free erythroprotoporphyrin. A study of Hb and iron stores in 20 males before and for 4 months following DDRC donation (Högler et al ., 2001) showed that Hb returned to predonation levels in all subjects within 2 months, whereas ferritin levels declined significantly from 54·2 ± 33·7 to 23·42 ± 21·94 ng mL −1 at 30 days postdonation and remained significantly below predonation levels, but within the normal range, until the end of the study period (4 months after donation). It was concluded that a 4‐month donation interval may be appropriate for red cell recovery but not for maintenance of iron stores.…”

Section: Donor Recruitment and Selectionmentioning

confidence: 99%

Automated red cell collection – quality and value

Harrison

2006

Transfusion Medicine

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Automated red cell collection was initially used largely for therapeutic purposes. New technology has rendered the procedure safer for donors and easier for machine operators. Optimal additive solution can be automatically added and the red cells filtered to provide a leucodepleted product. Two units of red cells may be collected during a single procedure from individuals who have a high enough red cell mass, whilst a single unit of red cells plus platelets or plasma can be collected from smaller donors. In vitro studies suggested that red cells collected by automated methods would be of better quality than those collected by gravity. This was not confirmed in vivo, but red cells collected by automated methods have the major advantage of consistency in terms of haemoglobin content, volume and haematocrit, compared with red cells collected by gravity. This standardised product is of particular value for transfusion dependent patients as the patient's haemoglobin can be maintained within narrow limits. The use of a double dose red cell product for transfusion to a single patient also confers benefit in terms of reduction in donor exposure.

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“…In the study by Högler et al . , 7 iron was not administered, and ferritin values declined significantly and remained below predonation values after 4 months. The present randomized, double‐blind, placebo‐controlled study demonstrates the positive effect of iron supplementation after repeated 2‐unit RBC apheresis during an 8‐ to 10‐week period.…”

Section: Discussionmentioning

confidence: 99%