Prospective evaluation of computed tomography and mediastinoscopy in mediastinal lymph node staging

Gdeedo, A; Schil, Paul Van; Corthouts, B.; Mieghem, François Van; Meerbeeck, Jan Van; Marck, E. Van

doi:10.1183/09031936.97.10071547

Cited by 164 publications

(75 citation statements)

References 33 publications

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“…Accuracy of CT in preoperative mediastinal lymph node staging was 45 to 79% (11)(12)(13)(14)(15). Recently, cervical mediastinoscopy or positron emission tomography (PET) scanning with 2-(fluorine-18) fluoro-2-deoxy-D-glucose (FDG) proved more accurate than computed tomography (CT) in demonstration and staging of nodal involvement (11)(12)(13).…”

Section: Effect Of Mediastinal Lymph Nodes Sampling In Patients With mentioning

confidence: 99%

Effect of mediastinal lymph nodes sampling in patients with clinical stage I non-small cell lung cancer

et al. 2008

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:Objective : Systematic nodal dissection has been recommended for patients with resectable non-small cell lung cancer because of its staging accuracy. However, in patients with clinical stage I non-small cell lung cancer whether systematic nodal dissection provides more benefits than mediastinal lymph node sampling or not is controversial. In this retrospective study, we evaluated the effect of mediastinal lymph node sampling in patients with clinical stage I NSCLC. Methods : One hundred and nineteen consecutive patients with clinical stage I NSCLC, who underwent curative operation between January 1994 and December 2000, were retrospectively reviewed (dissection group = 58 : sampling group= 61). Systematic nodal dissection was defined as complete removal of mediastinal lymph node, and mediastinal lymph node sampling was defined as removal of lymph node levels 3, 4, and 7 for right-sided tumors and levels 5, 6, and 7 for left-sided tumors. Results : The total number of removed mediastinal lymph nodes in patients who underwent systematic nodal dissection was 22.1 9.7, which was significantly higher than that in patients who underwent mediastinal lymph node sampling of 11.4 7.0 (p 0.001). Postoperatively N2 disease was detected in 8 patients (13.8% %) in the dissection group and 7 (11.5% %) in the sampling group. After the median follow up of 79 months, the cancer specific survival rate at 5 year was 78.0% % in the dissection group and 76.2% % in the sampling group (p = 0.60). Conclusions : Mediastinal lymph node sampling showed the similar effect to systematic nodal dissection in patients with clinical stage I non-small cell lung cancer. J. Med. Invest. 55 : 37-43, February, 2008

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Section: Effect Of Mediastinal Lymph Nodes Sampling In Patients With mentioning

confidence: 99%

Effect of mediastinal lymph nodes sampling in patients with clinical stage I non-small cell lung cancer

et al. 2008

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“…In the present study, metastatic lymph nodes were defined as mediastinal lymph nodes larger than 10 mm along the short axis on CT scan. However, in the diagnosis of mediastinal lymph node metastasis with CT scan, with a sensitivity of 40-75% and a specificity of 40-66%, is inferior to mediastinoscopy, with a sensitivity of 80% to 90% and a specificity of 100%, or to positron-emission tomography, with a sensitivity of 90% and a specificity of 86% (24)(25)(26). Additionally, the exact stage of T3 or T4 tumors is difficult to determine with a CT scan.…”

Section: Discussionmentioning

confidence: 99%

Induction chemoradiotherapy followed by surgery for locally advanced non-small cell lung cancer

Kusumoto

Hirose²,

Fukayama³

et al. 2009

Oncol Rep

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Abstract. We examined the efficacy and toxicity of a divided schedule of cisplatin and vinorelbine with concurrent radiotherapy followed by surgery in patients with locally advanced non-small cell lung cancer (NSCLC). Patients with clinical stage IIIA or IIIB NSCLC were eligible if they had a performance status of 0 or 1, were 75 years or younger, and had adequate organ function. Patients were treated with cisplatin (40 mg/m 2 ) and vinorelbine (20 mg/m 2 ) on days 1 and 8 every 3 weeks. Thoracic radiotherapy (2 Gy per fraction; total dose, 40 Gy) was given concurrently. Surgical resection was performed after induction therapy had been completed. If disease was considered clinically inoperable after induction therapy, patients received 2 additional cycles of the chemotherapy and 20 Gy of additional radiotherapy. Twenty-three patients (20 men and 3 women; median age, 63 years; age range, 45-72 years) were enrolled. The overall response rate was 78.3%. Although grade 3-4 toxicities included neutropenia in 95.7% of patients and anemia in 39.1%, no grade 3-4 radiation pneumonitis or esophagitis occurred. Thirteen patients (56.5%) underwent thoracotomy and complete resection. There were no treatment-related deaths. The median survival time was 36 months (range, 4-78 months), the 2-year survival rate was 74%, and the median time to disease progression was 15 months (range, 2-59 months). This trimodality therapy is effective and well tolerated and is an acceptable therapeutic option for patients with locally advanced NSCLC.

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“…O acesso aos linfonodos subcarinais e aos da janela aorto-pulmonar somente é conseguido através da mediastinostomia anterior. A mediastinoscopia tem rendimento diagnóstico que varia de 89 a 100% (48) . Ambos os procedimentos são realizados sob anestesia geral com mí-nima morbidade e mortalidade: respectivamente, 0,6% e 0,2% (49) .…”

Section: Diagnóstico Da Doença Mediastinalunclassified

Diagnóstico e estadiamento do câncer de pulmão

Fernandez

Jatene

Zamboni³

2002

J. Pneumologia

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O câncer do pulmão pode apresentar-se sob diversas formas e vários são os meios de diagnosticá-lo. A escolha do melhor método para o seu diagnóstico depende de diferentes aspectos relacionados ao tumor, ao paciente e à habilidade da equipe médica. Dentre os métodos mais comumente utilizados para o diagnóstico do câncer do pulmão, podemos contar, além dos exames radiológicos, que não serão abordados neste artigo, a citologia do escarro, a broncofibroscopia, a punção aspirativa transtorácica e a toracoscopia, entre outros. O estadiamento reflete a extensão anatômica do câncer.As

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Prospective evaluation of computed tomography and mediastinoscopy in mediastinal lymph node staging

Cited by 164 publications

References 33 publications

Effect of mediastinal lymph nodes sampling in patients with clinical stage I non-small cell lung cancer

Effect of mediastinal lymph nodes sampling in patients with clinical stage I non-small cell lung cancer

Induction chemoradiotherapy followed by surgery for locally advanced non-small cell lung cancer

Diagnóstico e estadiamento do câncer de pulmão

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