Prostate angiosarcoma: a case report and literature review

Abstract

Angiosarcomas are a relatively rare histological subtype of sarcomas and represent <1% of all sarcomas. Prostate angiosarcoma is extremely rare and displays remarkable clinical and pathological heterogeneity. Despite the rarity, it usually presents with dysuria, hematuria, or pelvic pain and represents a treatment challenge. Only nine cases have been reported in the literature, and we report the 10th case of prostate angiosarcoma and the first case of prostate angiosarcoma with recurrent adenocarcinoma.

Mesenchymal tumours of the bladder and prostate: an update

“…36 Angiosarcoma Angiosarcoma primary to the prostate is exceptionally rare, with only about 10 cases reported in the literature, according to two recent reviews. 37,38 Patients varied largely in age with a mean of 40 years, with one case reported in a 2-year-old child, ranging up to 80 years. [37][38][39][40][41][42][43] Two patients were in their 30s.…”

“…37,38 Patients varied largely in age with a mean of 40 years, with one case reported in a 2-year-old child, ranging up to 80 years. [37][38][39][40][41][42][43] Two patients were in their 30s. 41,42 In one of the cases, the angiosarcoma was an element of a prostatic teratoma.…”

Prostate angiosarcoma: is there any association with previous radiation therapy?

“…Khaliq et al . [12] reported the 10 th case, a 73-year-old man who had undergone external beam radiation therapy with brachytherapy boost for prostate adenocarcinoma 8 years previously and later presented with prostate angiosarcoma along with recurrent adenocarcinoma.…”

“…[14] proposed that radiation-induced sarcoma may occur in a previously irradiated area within a latent period of as long as 7 years. Although the association of angiosarcoma with radiation exposure has been described previously [15,16], only three out of 10 reported cases of prostate angiosarcoma had previous radiation exposure where PSA levels were within normal range or undetectable [9,11,12]. …”

Post-radiation epithelioid angiosarcoma of the urinary bladder and prostate

“…[1][2][3][4][5][6] There are only 14 reported cases of angiosarcoma of the prostate, five of which were associated with radiation therapy. [7][8][9][10][11][12][13] Epithelioid angiosarcoma is a variant of angiosarcoma composed of large rounded epithelioid endothelial cells that are positive for cytokeratin on immunostaining.…”