Protection against gastric ulcer by verapamil

Srivastava, Sudhir; Nath, Chandishwar; Gupta, M. K. Das; Vrat, S.; Sinha, J. N.; Dhawan, K.N.; Gupta, G.P.

doi:10.1016/s1043-6618(05)80109-4

Cited by 40 publications

(17 citation statements)

References 7 publications

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“…Ulcers formed in stomach of CRU and pyloric ligated rats were scored according to the arbitrary scoring system (Srivastava et al 1991) and graded as follows: (1) shedding of epithelium =10, (2) petechial and frank hemorrhages= 20; (3) one or two ulcers=30, (4) more than two ulcers=40, and (5) perforated ulcers=50. In the AL model, the length of the lesions were measured using a Biovis image analyzer software (Expert Vision Lab Private Ltd., Mumbai, India) and summated to give a total lesion score.…”

Section: Measurement Of Ulcer Indexmentioning

confidence: 99%

Gastroprotective effect of anti-cancer compound rohitukine: possible role of gastrin antagonism and H+ K+-ATPase inhibition

Singh

Shrivastva

et al. 2011

Naunyn-Schmiedeberg's Arch Pharmacol

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The present study was designed to evaluate the anti-ulcerogenic properties of an alkaloid chromane, rohitukine from Dysoxylum binectariferum. Anti-ulcer potential of rohitukine was assessed in cold restrained, pyloric ligated and ethanol induced ulcers in rats. In addition, rohitukine was tested in vitro for H(+) K(+)-ATPase inhibitory activity in gastric microsomes. Moreover, we studied the role of rohitukine on the cytosolic concentration of Ca(2+) in parietal cell-enriched cell suspension in order to ascertain its mechanism of action. Cytoprotective activity was evaluated through PGE(2) level. Rohitukine significantly attenuated the ulcers in cold restraint ulcer (CRU) model in a dose-related manner. Moreover, it significantly lowered the free acidity and pepsin activity in pyloric ligated rats while improved the depleted level of mucin. Furthermore, rohitukine significantly reversed the cold restrained-induced increase in gastrin level. Our in vitro study revealed that rohitukine moderately inhibited the microsomal H(+) K(+)-ATPase activity with respect to positive control omeprazole. Furthermore, rohitukine potently antagonized the gastrin-elicited increase in cytosolic Ca(2+) level in parietal cell-enriched suspension. In ethanol-induced gastric lesions in rats, rohitukine significantly inhibited the formation of erosions and increased PGE(2) content showing more potency than reference drug sucralfate. Our results thus suggest that rohitukine possess significant anti-ulcer and anti-gastrinic activity in rats. It is likely that gastro-protective influences of rohitukine are dependent partly on its acid-lowering potential and partly on cytoprotective property. The acid-reducing effect of rohitukine might be attributed to its lowering effect on gastrin production and/or antagonism of gastrin-evoked functional responses of parietal cells. Thus, rohitukine represent a useful agent in the treatment of peptic ulcer disease.

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Section: Measurement Of Ulcer Indexmentioning

confidence: 99%

Gastroprotective effect of anti-cancer compound rohitukine: possible role of gastrin antagonism and H+ K+-ATPase inhibition

Singh

Shrivastva

et al. 2011

Naunyn-Schmiedeberg's Arch Pharmacol

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“…Ulcers were scored with the help of arbitary scale as described earlier (Srivastava et al, 1991). The following arbitary scoring system was used to grade the incidence and severity of the lesions: (i) shedding of epithelium = 10; (ii) petechial and frank hem- Fig.…”

Section: Measurement Of Ulcer Indexmentioning

confidence: 99%

Evaluation of anti-ulcerogenic and ulcer-healing properties of Ocimum sanctum Linn.

Dharmani

Kuchibhotla

Maurya

et al. 2004

Journal of Ethnopharmacology

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“…[24] AERC depicted significant effectiveness (P<0.01) in PL-induced gastric ulcers showing a 40.73% protection index at dose 400 mg/kg whereas ranitidine showed a 62.95% protection index. AERC significantly (P<0.05-0.01) increased the defensive mucin secretion quantified in terms of TC: P ratio of the gastric juice [25] at 200 and 400 mg/kg doses.…”

Section: Discussionmentioning

confidence: 89%

Antiulcer potential of Rubia cordifolia Linn. in experimental animals

Kalra¹,

Sharma²,

Datusalia³

2011

Int J Green Pharm

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Alcoholic extract of roots of Rubia cordifolia Linn. (AERC) has been examined to evaluate its antiulcer potential on alcohol, ibuprofen, cold-restraint stress and pyloric ligation-induced gastric lesions. AERC of 100-400 mg/kg was administered orally, once daily for 15 days, to rats of different groups. Ranitidine at a dose of 50 mg/kg was used as a standard drug for these gastric ulcer models. The gastric content was collected and the volume was measured. The ulceration index was determined by examining the inner lining of each stomach. Furthermore, the effect was assessed by free acidity, pepsin activity, total carbohydrate, protein content. The extract demonstrated significant protection against 100% alcohol-(P<0.05-0.01), ibuprofen-(P<0.05-0.01), cold-restraint stress-(P<0.01) and pylorus ligation-(P>0.01-P>0.01) compared to ranitidine (P<0.01).

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Protection against gastric ulcer by verapamil

Cited by 40 publications

References 7 publications

Gastroprotective effect of anti-cancer compound rohitukine: possible role of gastrin antagonism and H+ K+-ATPase inhibition

Gastroprotective effect of anti-cancer compound rohitukine: possible role of gastrin antagonism and H+ K+-ATPase inhibition

Evaluation of anti-ulcerogenic and ulcer-healing properties of Ocimum sanctum Linn.

Antiulcer potential of Rubia cordifolia Linn. in experimental animals

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