Protective effect of basic fibroblast growth factor on retinal injury induced by argon laser photocoagulation

Abstract

Laser photocoagulation treatment is often complicated by a side effect of visual impairment, which is caused by the unavoidable laser-induced retinal destruction. At present no specific is found to cure this retinopathy. The aim of this study was to observe the neuroprotective effect of bFGF on laserinduced retinal injury. Chinchilla rabbits were divided into three groups and argon laser lesions were created in the retinas. Then bFGF or dexamethasone, a widely used ophthalmic preparation, or saline was given severally by retrobulbar injection. The retinal lesions were evaluated histologically and morphometrically, and visual function was examined by ERG. The results showed that bFGF administration better preserved morphology of retinal photoreceptors and significantly diminished the area of the lesions. Furthermore, bFGF promoted the restoration of the ERG b-wave amplitude. In rabbits treated with dexamethasone, however, the lesions showed almost no ameliorative changes. This is the first study to investigate the potential role of bFGF as a remedial agent in laser photocoagulation treatment. These findings suggest that bFGF has significant neuroprotective properties in the retina and this type of neuroprotection may be of clinical significance in reducing iatrogenic laser-induced retinal injuries in humans. Time after exposure, day

Fluorescence photobleaching dynamics of meso tetra hydroxy phenyl chlorin (mTHPC)

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Optical image analysis of fat cells for indocyanine green mediated near-infrared laser treatment

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Wound treatment on a diabetic rat model by a 808 nm diode laser

“…In recent years, lasers have been widely used in many medical fields [1][2][3]: photostimulation development for biological research and clinical application [4][5][6]. Healing is a natural process of human skin and epidermal tissue regeneration trauma.…”