Protective effect of<i>Astragalus membranaceus</i>on intestinal mucosa reperfusion injury after hemorrhagic shock in rats

Hei, Ziqing; Huang, Heqing; Zhang, Mengjie; Chen, Bingxue; Li, Xiaoyun

doi:10.3748/wjg.v11.i32.4986

Cited by 46 publications

(25 citation statements)

References 26 publications

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“…Astragalus membranaceus is widely used for prevention of ROS-mediated injury in pathological situation through its antioxidant properties. 13,[31][32][33] In an in vitro study, it was demonstrated by electron paramagnetic resonance imaging technique that Astragalus membranaceus can potently inhibit ROS produced by the dimethyl sulphoxide system and scavenge over 90% of ROS. 34) Recently, the emerging experiments reported that a herbal formulation, comprising Astragalus membranaceus, improved the pancreatic beta cell function via the antioxidative effect.…”

Section: Discussionmentioning

confidence: 99%

Astragaloside IV Improves Homocysteine-Induced Acute Phase Endothelial Dysfunction via Antioxidation

Qiu

Xie

Zhang

2010

Biological & Pharmaceutical Bulletin

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Hyperhomocysteinemia is an independent risk factor for cardiovascular disease.1) Elevation of homocysteine (HCY) in blood plasma (Ͼ15 mmol/l), resulting from metabolic abnormalities in HCY remethylation or transsulfuration, is common in subjects with cardiovascular disease. In the last decade, insights from the animal models have established that experimental hyperhomocysteinemia produces several phenotypic effects, including endothelial dysfunction. The most common abnormality of the dysfunction observed during hyperhomocysteinemia is impaired relaxation of conduit vessels (aorta, carotid arteries, renal, or pulmonary) or impaired dilatation of micro vessels (mesenteric, cremasteric, coronary, skeletal, or cerebral arterioles) in response to the endothelium-dependent vasodilators in rat, mice, monkey, or guinea pigs, whereas no impairment was seen in response to exogenous nitric oxide (NO) donors.2-8) Therefore, it was suggested that the underlying mechanism by which endothelium derived NO, which then diffuses into the adjacent vascular muscle layer and causes its relaxation, may play an important role in mediating these deleterious effects on endothelial function in hyperhomocysteinemia. 2,5,8) Furthermore, the emerging evidence suggest that hyperhomocysteinemia leads to increased vascular superoxide production through the upregulation and activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, and that reactive oxygen species (ROS) generated by NADPH oxidase contribute to the vascular phenotype. 4,[9][10][11] Radix Astragali is the dried root of Astragalus membranaceus (FISCH.) BGE. var. mongholicus (BGE.) HSIAO or Astragalus membranaceus (FISCH.) BGE. It has been widely used in Chinese medicine since ancient times for the improvement of immune disorders and management of cardiovascular diseases with an excellent safety.12) Research suggests that this herb was able to inhibit free radicals, decreases lipid peroxidation, and increases antioxidant enzymes.13) Many medicinally active compounds have been isolated from this plant, including polysaccharides, flavones and astragalosides. Astragalosides is the major active component extracted from the root of Astragalus membranaceus.12) Previous studies from our laboratory demonstrated that crude astragalosides fraction can potently protect endothelium-dependent relaxation against the acute injury from HCY through nitric oxide regulatory pathways, in which antioxidation played a key role. 14)Astragaloside IV (AST-IV), 3-o-beta-D-xylopyranosyl-6-obeta-D-glucopyranosyl-cycloastragenol (Fig. 1), was a small molecular saponin. AST-IV can exert multipotent activities under pathophysiological conditions, such as anti-hypertension, 15) positive inotropic action, 16) anti-inflammation, 17) and anti-infarction.18) Up to now, however, whether AST-IV has an exact protective effect on vessels in hyperhomocysteinemia and the mechanism are not known. The aim of the present study is to examine the effect of AST-IV on vasomotor dysfunction induced by HCY in rat ao...

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Section: Discussionmentioning

confidence: 99%

Astragaloside IV Improves Homocysteine-Induced Acute Phase Endothelial Dysfunction via Antioxidation

Qiu

Xie

Zhang

2010

Biological & Pharmaceutical Bulletin

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“…This herb has demonstrated high antioxidant activity in protecting against intestinal mucosal reperfusion injury in rats. 26 Because this was an in vivo study, it is possible that antioxidant activity was modified within the whole animal. Although we have analyzed the lipophilic and hydrophilic radical-quenching capacity using the ORAC assay, which has been found to be the most relevant for biologic samples, 27 limitations of in vitro antioxidant assays include the fact that they do not account for bioavailability, retention of antioxidants by tissues, and reactivity in vivo.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Capacity of 55 Medicinal Herbs Traditionally Used to Treat The Urinary System: A Comparison Using A Sequential Three-Solvent Extraction Process

Wojcikowski

Stevenson

Leach

et al. 2007

The Journal of Alternative and Complementary Medicine

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“…Medicinally, AR is used as a diuretic and tonic herb in many Asian countries, to enhance physical strength and endurance, strengthen the immune system, lower blood pressure, and promote excretion and circulation (Zhao et al, 1990;Sheng et al, 2001;Yu et al, 2006). Clinically, AR is used to treat chronic phlegmatic disorders and general gastrointestinal disturbances including stomach ulcers and diarrhea (Yang, 1993;Hei et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Astragali Radix elicits anti-inflammation via activation of MKP-1, concomitant with attenuation of p38 and Erk

Ryu

Kim

Chun

et al. 2008

Journal of Ethnopharmacology

149

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Protective effect ofAstragalus membranaceuson intestinal mucosa reperfusion injury after hemorrhagic shock in rats

Cited by 46 publications

References 26 publications

Astragaloside IV Improves Homocysteine-Induced Acute Phase Endothelial Dysfunction via Antioxidation

Astragaloside IV Improves Homocysteine-Induced Acute Phase Endothelial Dysfunction via Antioxidation

Antioxidant Capacity of 55 Medicinal Herbs Traditionally Used to Treat The Urinary System: A Comparison Using A Sequential Three-Solvent Extraction Process

Astragali Radix elicits anti-inflammation via activation of MKP-1, concomitant with attenuation of p38 and Erk

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