Protective Effect of Nigella sativa Seeds Against Lead-induced Hepatorenal Damage in Male Rats

Farrag, Ashraf; Mahdy, Karam A; Rahman, Gamal H Abdel; Osfor, M. M. H.

doi:10.3923/pjbs.2007.2809.2816

Cited by 41 publications

(12 citation statements)

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“…In the present study, treatment with LA (LAwS) resulted in a significant increase of LIP as indicated by the significant increase of MDA levels and the significant decrease of GSH levels. Similar results have been reported [12,38-40]. The observed LIP in the current study may also assume that there was a disruption of prooxidant/antioxidant balance in lead exposure.…”

Section: Discussionsupporting

confidence: 92%

“…Lead produces oxidative damage in the kidney, by enhancing LIP [11,12]. In the present study, treatment with LA (LAwS) resulted in a significant increase of LIP as indicated by the significant increase of MDA levels and the significant decrease of GSH levels.…”

Section: Discussionmentioning

confidence: 48%

“…On the other hand, lead is known to also affect the kidney, which is another important target [10]. Lead produces oxidative damage in the kidney as evidenced by enhancing lipid peroxidation (LIP) [11,12]. …”

Section: Introductionmentioning

confidence: 99%

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Protective effects of Spirulina maxima on hyperlipidemia and oxidative-stress induced by lead acetate in the liver and kidney

et al. 2010

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BackgroundOxidative damage has been proposed as a possible mechanism involved in lead toxicity, specially affecting the liver and kidney. Previous studies have shown the antioxidant effect of Spirulina maxima in several experimental models of oxidative stress. The current study was carried out to evaluate the antioxidant activity of Spirulina maxima against lead acetate-induced hyperlipidemia and oxidative damage in the liver and kidney of male rats. Control animals were fed on a standard diet and did not receive lead acetate (Control group). Experimental animals were fed on a standard laboratory diet with or without Spirulina maxima 5% in the standard laboratory diet and treated with three doses of lead acetate (25 mg each/weekly, intraperitoneal injection) (lead acetate with Spirulina, and lead acetate without Spirulina groups).ResultsThe results showed that Spirulina maxima prevented the lead acetate-induced significant changes on plasma and liver lipid levels and on the antioxidant status of the liver and kidney. On the other hand, Spirulina maxima succeeded to improve the biochemical parameters of the liver and kidney towards the normal values of the Control group.ConclusionsIt was concluded that Spirulina maxima has protective effects on lead acetate-induced damage, and that the effects are associated with the antioxidant effect of Spirulina.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 48%

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Protective effects of Spirulina maxima on hyperlipidemia and oxidative-stress induced by lead acetate in the liver and kidney

et al. 2010

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“…The antioxidant properties of N. sativa has been well documented previously (67,68,69), therefore its administration protects hepatic tissue from deleterious effects of toxic metals such as lead, and attenuates hepatic lipid peroxidation following exposure to chemicals such as carbon tetrachloride. ( 70,71).Accordingly, the antioxidant activity of both vitamin E and flavoniods restore cellular integrity with maintaining liver function including maintaining bilirubin concentration.…”

Section: Groupsmentioning

confidence: 99%

Effect of Flavonoids Extracted from Black Cumin (Nigella sativa) and Vitamin E in Ameliorating Hepatic Damage Induced by Sodium Nitrate in adult male rats

Al-Okaily

Mohammed²,

Al-Mzain³

et al. 2012

Iraqi J. Vet. Med.

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This study was designed to investigate the effect of sodium nitrate as oxidant agent on hepatic function of adult male rats, as well as the possible protective role of vitamin E and flavonoid extracted from Nigella Sativa seeds against the deleterious effects of sodium nitrate. Forty adult male rats were randomly divided in to 4 equal groups and treated daily for 84 days as follows: Animals in the first group were received normal saline, serving as control (group C), rats of the second group (T1) were intubated orally sodium nitrate 30mg/kg. B.W.; animals in T2 group were intubated orally vit. E 40mg/Kg B.W. in addition to sodium nitrate, while rats in the fourth group (T3) were intubated orally 50mg/kg B.W of flavonoids was extracted from Nigella Sativa seeds with sodium nitrate. Blood samples were collected at 0, 21, 42, 63 and 84 days of experiment to study the following parameters: Serum alanine aminotransferase (ALT) and alkaline phosphtase activity (ALP), serum billirubin, as well as hemoglobin concentration. The result revealed that oral intubation of 30mg/kg. B.W of sodium nitrate (T1 group) for 84 days caused hepatic damage manifested by significant increase (p<0.05) in serum ALT and ALP activities, bilirubin concentration and depression in hemoglobin concentration. On other hand, the protective role of vitamin E and flavonoids extracted from Nigella Sativa was clarified in groupsT2 and T3, including correction of hepatic damage manifested by significant (p<0.05) depression in ALT and ALP activities and bilirubin concentration as well as significant (p<0.05) elevation in hemoglobin concentration. In conclusion, the results of this study confirm the protective role of vitamin E and flavonoids of Nigella sativa seed against hepatic dysfunction caused by sodium nitrate manifested by structural and functional changes.

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“…The active constituent of Nigella sativa principally thymoquinone have potential therapeutic properties; they exhibited anti-inflammatory effect on several inflammatory disorders including encephalomyelitis, colitis, edema and arthritis through suppression of prostaglandin and leukotriene as inflammatory mediator [13]. The protective effect of N. sativa against lead acetate induced liver toxicity in male rats was demonstrated [14].…”

Section: Introductionmentioning

confidence: 99%

The effect of fixed oil extracts of Nigella sativa on sickle cells: An in-vitro study in Khartoum state -Sudan

Dafaalla¹,

Humeida²

2021

World J. Adv. Res. Rev.

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In Sudan, sickle cell anemia (SCA) is one of the most common inherited disorders of hemoglobin that has complications and becomes world problem. Nigella sativa NS (black seed) has been reported to have calcium antagonist and antioxidant activities, both of which play a role in the management of sickle cell anemia. The aim of the current study was to evaluate of the anti-sickling activity of the NS extracts, forty patients with sickle cell anemia were recruited for the study. A total of 3ml of venous blood was collected from each patient after obtaining the consent and the ethical approval, the blood was treated with Nigella sativa (NS) extract, and sickling test was performed. Descriptive study and p-values were used, and the correlation was evaluated, data was analyzed by SPSS. Recent study found that the sickling test after treating blood with Nigella sativa extract showed a negative result in 75% of patients and a 25% of patients showed persistently positive sickling test result. The anti-sickling effect in relation to various hemoglobin concentration, gender and age group showed p values of 0.007, 0.672 and 0.853 respectively indicating significant relationship with Hb concentration. Our study concluded that the fixed oil extract from Nigella sativa has an in-vitro anti-sickling activity on patients with SCA and this finding could indicate the use of this extract in treatment.

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Protective Effect of Nigella sativa Seeds Against Lead-induced Hepatorenal Damage in Male Rats

Cited by 41 publications

References 0 publications

Protective effects of Spirulina maxima on hyperlipidemia and oxidative-stress induced by lead acetate in the liver and kidney

Protective effects of Spirulina maxima on hyperlipidemia and oxidative-stress induced by lead acetate in the liver and kidney

Effect of Flavonoids Extracted from Black Cumin (Nigella sativa) and Vitamin E in Ameliorating Hepatic Damage Induced by Sodium Nitrate in adult male rats

The effect of fixed oil extracts of Nigella sativa on sickle cells: An in-vitro study in Khartoum state -Sudan

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