Protective effect of Xin-Ji-Er-Kang on cardiovascular remodeling in high-salt induced hypertensive mice: Role ofoxidative stress and endothelial dysfunction

Wang, Xiaoyun; Huang, Guang-yao; Lian, Feng-zhen; Pan, Min‐Hsiung; Ruan, Cheng-shao; Ling, Xin-xin; Chen, Mei‐Ling; Shen, Adong; Gao, Shan

doi:10.1016/j.biopha.2019.108937

Cited by 20 publications

(15 citation statements)

References 45 publications

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“…Previous research suggests that LVH enhanced cardiovascular diseases related mortality and morbidity (Lang et al., 2018 ; Wang et al., 2019 ). It is proofed that the CVD risk factors are linked with the expansion of LVH.…”

Section: Discussionmentioning

confidence: 96%

“…Before, the insertion of the catheters, it should be soaked into the Alconox for 30 min. The rate of LV pressure rise, LV end-diastolic pressure (LVEDP) and LV systolic pressure (LVSP) were recorded (Wang et al., 2019 ).…”

Section: Methodsmentioning

confidence: 99%

“…At the end of the experimental study, all group mice were sacrificed and the heart tissue were successfully removed and calculated the heart to body weight ratio (HW/BW) by dividing the heart weight (HW) via body weight (BW) after the harvest and weighting the hearts (Lang et al., 2018 ; Wang et al., 2019 ).…”

Section: Methodsmentioning

confidence: 99%

“…Previous research suggests that obesity has been described as an inflammatory state and oxidative stress and chronic inflammation play an imperative role in the pathogenesis of obesity and related complications (Abel & Doenst, 2011 ; Rosca et al., 2013 ). It has been confirmed that the, during the obesity enhance the level of fatty acid, which further activated the nuclear factor kappa B (NF-kB) pathway, afterward, boost the expression of inflammatory cytokines and reaction and inducing the oxidative stress (Silambarasan et al., 2014 ; Wang et al., 2019 ). Still, the molecular mechanisms involved in obesity-related cardiac hypertrophy still unclear.…”

Section: Introductionmentioning

confidence: 97%

“…It is well documented that cardiac hypertrophy is the risk factor for adverse CVD events. Various factors are involved in the pathophysiology of cardiac hypertrophy such as oxidative stress and inflammation plays a crucial role in the expansion of disease (Silambarasan et al., 2014 ; Wang et al., 2019 ). Among cardiovascular disease, obesity has a great impact on cardiac remodeling and its function such as myocardial fibrosis, damaged ventricular contractility and hemodynamic load, which leads to the expansion of heart failure (Mooney, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

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Thiopental sodium loaded solid lipid nano-particles attenuates obesity-induced cardiac dysfunction and cardiac hypertrophy via inactivation of inflammatory pathway

Zhu

Wang

et al. 2020

Drug Delivery

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This work evaluates solid lipid nanoparticles of thiopental sodium against obesity-induced cardiac dysfunction and hypertrophy and explores the possible mechanism of action. TS loaded SLNs were formulated by hot-homogenization and solvent diffusion method. TS-SLNs were scrutinized for entrapment efficiency, drug loading capacity, gastric stability, particle size, in vitro drug release. Mice were feed with the normal chow or high-fat diet for 08 weeks to induce obesity and primary cardiomyocytes. The therapeutic effects of thiopental sodium in the high fat diet (HFD) induced cardiac hypertrophy. Systolic blood pressure (SBP) was estimated at a regular time interval. At the end of the experimental study, systolic pressure left ventricular, LV end-diastolic pressure and rate of increase of LV pressure and antioxidant, apoptosis, cytokines and inflammatory scrutinized. HFD induced group mice exhibited a reduction in the body weight and enhancement of cardiac hypertrophy marker and dose-dependent treatment of thiopental sodium up-regulation the body weight and down-regulated the cardiac hypertrophy. Thiopental sodium significantly (p < .001) dose-dependently altered the antioxidant, biochemical, cardiac parameters and remodeling. Thiopental sodium significantly (p < .001) dose-dependently reduced the SBP. Thiopental sodium altered the apoptosis marker, pro-inflammatory cytokines, inflammatory parameters along with reduced the p38-MAPK level. The cardiac protective effect of thiopental sodium shed light on future therapeutic interventions in obesity and related cardiovascular complications via inflammatory pathway.

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Section: Discussionmentioning

confidence: 96%

Section: Methodsmentioning

confidence: 99%