Protective effects of amentoflavone on Lamin A-dependent UVB-induced nuclear aberration in normal human fibroblasts

Park, Nok-Hyun; Lee, Chan‐Woo; Bae, Ji-Hyun; Na, Yong Joo

doi:10.1016/j.bmcl.2011.08.067

Cited by 33 publications

(22 citation statements)

References 11 publications

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“…It is also consistent with the previous findings that tumor promotion of carcinogen was positively relevant to its prooxidant and ROS generation [28]. Since amentoflavone could efficiently scavenge excessive ROS which are well known to cause aging, and amentoflavone could be used for the treatment of skin aging induced by UV irradiation [3][4], hence it can be inferred that its pharmacological effect on skin aging is assumed to be via antioxidant mechanism. Finally, anti-inflammatory effects of amentoflavone are also thought to be mainly attributed to its antioxidant ability.…”

Section: Resultssupporting

confidence: 90%

“…Since natural flavonoid plays a critical role in human nutrition and health, therefore its beneficial effects on DNA have attracted increasing attention over the past decade [2]. As a typical biflavonoid naturally occurring in many plants, amentoflavone ( Figure 1) has recently been reported to present radioprotective [3][4] and antiinflammation [5][6] effects. According to free radical biology and medicine [7], we hypothesized that these effects of amentoflavone may be associated with protection against DNA damage induced by ROS.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Amentoflavone Protects against Hydroxyl Radical-induced DNA Damage via Antioxidant Mechanism

Li¹,

Wang²,

Han³

et al. 2014

Turk J Bioch

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Section: Resultssupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Amentoflavone Protects against Hydroxyl Radical-induced DNA Damage via Antioxidant Mechanism

Li¹,

Wang²,

Han³

et al. 2014

Turk J Bioch

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“…A number of studies have demonstrawted that AMF exerts anti-inflammatory (17–20), antioxidant (25–27), anti-viral (28,29) and antitumor effects (30,31), as well as protective effects against radiation-induced damaqge (32,33) and neuroprotective effects (32,33). Na et al found that AMF inhibited protein tyrosine phosphatase 1B activity, implicating a potential use of AMF in the treatment of type 2 diabetes and obesity (21).…”

Section: Discussionmentioning

confidence: 99%

Amentoflavone protects against high fat-induced metabolic dysfunction: Possible role of the regulation of adipogenic differentiation

Chen

Han

et al. 2016

International Journal of Molecular Medicine

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In the present study, we evaluated the protective effects of amentoflavone (AMF) against high-fat (HF) diet-induced metabolic dysfunction and focused on the influence of AMF on adipogenic differentiation during 3T3-L1 adipocyte differentiation. For this purpose, male Wistar rats were fed a HF diet or a HF diet with AMF (10 or 50 mg/kg). We found that AMF protected against HF diet-induced metabolic dysfunction in a dose-dependent manner, as evidenced by a decrease in the fasting blood glucose levels, fasting insulin levels and the homeostatic model assessment-insulin resistance index (HOMA-IR), as well as by a decrease in the glucose level, as shown by the intraperitoneal glucose tolerance test and intraperitoneal insulin tolerance test. Moreover, the results revealed that AMF significantly inhibited the increase in body weight, the weight of perirenal adipose tissues and the serum triglyceride (TG) content of the rats fed the HF diet in a dose-dependent manner. AMF also inhibited the accumulation of oil droplets in differentiated 3T3-L1 adipocytes in a concentration-dependent manner. The incubation of the cells with AMF for 0–8, 0–2, 2–4, or 4–8 days markedly inhibited adipogenesis. During the early phase of the adipocyte differentiation of 3T3-L1 cells, AMF decreased CCAAT/enhancer-binding protein (C/EBP) β expression in a concentration-dependent manner, leading to the inhibition of mitotic clonal expansion (MCE). Moreover, our results demonstrated that AMF significantly increased reactive oxygen species (ROS) generation in the cells and the antioxidant, N-acetylcysteine (NAC), markedly attenuated the inhibitory effects of AMF on adipogenesis. AMF also inhibited the expression of peroxisome proliferator-activated receptor γ (PPARγ) and C/EBPα and the expression of downstream targets in a concentration-dependent manner. The overexpression of PPARγ and C/EBPα (by transfection with respective overexpression plasmids) attentuated the inhibitory effects of AMF on the formation of oil droplets. The inhibitory effects of AMF on adipocyte differentiation may contribute to its protective effects against HF diet-induced metabolic dysfunction. Overall, the data in our study provide novel insight into the mechanisms responsible for the protective effects of AMF against HF diet-induced metabolic dysfunction and those for its inhibitory effect on adipocyte differentiation.

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“…From then on, phytochemical researchers have isolated and identified this biflavonoid from more than 120 plants, some of which have been used as traditional folk medicines in many regions of the world for even thousands of years. With the development of modern pharmacology, more and more evidence has proved many of the bioactivities of amentoflavone, including anti-oxidant [ 2 ], anti-inflammatory [ 3 ], anti-senescence [ 4 ], anti-tumor [ 5 ], anti-virus [ 6 ], and anti-fungal [ 7 ] effects, as well as therapeutic effects on the central nervous system [ 8 ] and cardiovascular system [ 9 ], etc. With its good pharmacological performance and high content, amentoflavone is even listed as the chemical marker of Selaginellae Herba (“Juanbai” in Chinese, which represents the whole plants of Selagenella tamariscina or Selaginella pulvinata ) for quality evaluation in the Chinese Pharmacopoeia [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

A Review on the Phytochemistry, Pharmacology, and Pharmacokinetics of Amentoflavone, a Naturally-Occurring Biflavonoid

et al. 2017

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Amentoflavone (C30H18O10) is a well-known biflavonoid occurring in many natural plants. This polyphenolic compound has been discovered to have some important bioactivities, including anti-inflammation, anti-oxidation, anti-diabetes, and anti-senescence effects on many important reactions in the cardiovascular and central nervous system, etc. Over 120 plants have been found to contain this bioactive component, such as Selaginellaceae, Cupressaceae, Euphorbiaceae, Podocarpaceae, and Calophyllaceae plant families. This review paper aims to profile amentoflavone on its plant sources, natural derivatives, pharmacology, and pharmacokinetics, and to highlight some existing issues and perspectives in the future.

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Protective effects of amentoflavone on Lamin A-dependent UVB-induced nuclear aberration in normal human fibroblasts

Cited by 33 publications

References 11 publications

Amentoflavone Protects against Hydroxyl Radical-induced DNA Damage via Antioxidant Mechanism

Amentoflavone Protects against Hydroxyl Radical-induced DNA Damage via Antioxidant Mechanism

Amentoflavone protects against high fat-induced metabolic dysfunction: Possible role of the regulation of adipogenic differentiation

A Review on the Phytochemistry, Pharmacology, and Pharmacokinetics of Amentoflavone, a Naturally-Occurring Biflavonoid

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