Protective Effects of Green Tea Extract against Hepatic Tissue Injury in Streptozotocin-Induced Diabetic Rats

Abstract

Although diabetic hepatopathy is potentially less common, it may be appropriate for addition to the list of target organ conditions related to diabetes. This study was designed to evaluate the hepatoprotective properties of green tea extract (GTE) in STZ-induced diabetes in rats. Wistar rats were made diabetic through single injection of STZ (75 mg/kg i.p.). The rats were randomly divided into four groups of 10 animals each: Group 1, healthy control; Group 2, nondiabetics treated with GTE administered orally (1.5%, w/v); Group 3, diabetics; Group 4, diabetics treated with GTE (1.5%, w/v) for 8 weeks. Serum biomarkers were assessed to determine hepatic injury. Malondialdehyde (MDA) and reduced glutathione (GSH) contents were measured to assess free radical activity in the liver tissue. Hepatic antioxidant activities of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase (CAT) were also determined. The biochemical findings were matched with histopathological verifications. Liver MDA content and serum levels of ALT, AST, ALP, and bilirubin in Group 3 significantly increased compared to Group 1 (P < 0.05) and significantly decreased in Group 4 compared to Group 3 (P < 0.05). Serum albumin level and GSH, SOD, CAT, and GSH-Px contents of the liver in Group 3 were significantly decreased compared to Group 1 (P < 0.05) and were significantly increased in Group 4 compared to Group 3 (P < 0.05). Histopathologically, the changes were in the same direction with biochemical findings. This study proved the hepatoprotective activity of GTE in experimentally induced diabetic rats.

Combinatorial Effects of Aqueous Root Extract of Jatropha Curcas and J. Gossypiifolia in Alloxan-Induced Diabetic Rats

“…Such agents include sulphonylureas and biguanides, despite the report on their negative effects. Therefore, in searching for alternative agent that will be cheaper and safer, attention has now been focused on the use of medicinal plants for the management of diabetes disease ( [12][13][14].…”

Hypolipidemic Action of hydroxycinnamic Acids from Cabbage (<i>Brassica oleracea L. var. capitata</i>) on Hypercholesterolaemic Rat in Relation to Its Antioxidant Activity

“…Mateos reported that, fruit powders rich in phenolic compounds are very effective in reducing lipid peroxidation in hypercholesterolaemic rats [29]. Furthermore, oral feeding of green tea reduces hyperlipidemia and enhances the activities of SOD and CAT in rats [30]. These studies revealed that beneficial effects of phenolic compounds maybe mediated by one or more mechanisms such as by inhibiting lipid peoxidation, platelet aggregation and enhancing of antioxidant defense.…”

Antioxidant and Antidiabetic Activity of Aqueous Extract of Myrtus Communis L. Berries on Streptozotocin-Induced Diabetic Rats

“…Elevated serum MDA levels are considered to be an indicator of cellular membrane injury caused by oxidative stress 30 . Many studies have reported on diminished enzymatic and non-enzymatic antioxidant activities in diabetic rats 31,32 . Oxidative stress resulting from excessive production of ROS has been suggested to be a potential mechanism involved in diabetic hepatopathy 32 and other complications 33,34 .…”

“…Many studies have reported on diminished enzymatic and non-enzymatic antioxidant activities in diabetic rats 31,32 . Oxidative stress resulting from excessive production of ROS has been suggested to be a potential mechanism involved in diabetic hepatopathy 32 and other complications 33,34 . In the current study, the administration of aqueous extract of MC berries provided a significant improvement in the antioxidant system, namely an increment in SOD activity and GSH levels and a reduction in MDA levels.…”