Proteomics and Nutrition Research

Tewari, Arun K.; Mohanty, Sudhasri; Roy, Sashwati

doi:10.1002/9781118930458.ch18

Cited by 4 publications

(4 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite variations in the serum concentration of immunoglobulins, after supplementation with Macleaya cordata extract, we observed a healthy response in growing pigs ( Table 2 ). According to the work of Tewari et al [ 18 ], the underlying mechanisms that regulate immunological function are likely to be multifactorial. As such, they recommended that future studies use molecular biology and proteomics technologies.…”

Section: Discussionmentioning

confidence: 99%

Macleaya cordataExtract Decreased Diarrhea Score and Enhanced Intestinal Barrier Function in Growing Piglets

Liu

Guan

Fang

et al. 2016

BioMed Research International

View full text Add to dashboard Cite

Macleaya cordata extract is of great scientific and practical interest to researchers, due to its antimicrobial and anti-inflammatory responses within experimental animals. This study was designed to determine the diarrhea score and innate immunity of growing piglets after they had received Macleaya cordata extract supplements. A total of 240 growing pigs were randomly assigned to one of three dietary treatments, with 8 replicates per treatment and 10 piglets per replicate. All pigs received a basal diet containing similar amounts of nutrients. The three treatments were a control (no additive), an antibiotic (200 mg/kg colistin), and the Macleaya cordata extract supplement group (40 mg/kg Macleaya cordata extract). The diarrhea score was calculated after D 28. The jejunal samples were obtained from five piglets selected randomly from each treatment on D 28. In comparison with the control group, the dietary Macleaya cordata extract and colistin group demonstrated a substantially decreased diarrhea score. The introduction of Macleaya cordata extract supplements to the diet significantly increased volumes of ZO-1 and claudin-1, particularly in comparison with the pigs in the control group (P < 0.05). The findings indicate that Macleaya cordata extract does enhance intestinal barrier function in growing piglets and that it could be used as a viable substitute for antibiotics.

show abstract

Section: Discussionmentioning

confidence: 99%

Macleaya cordataExtract Decreased Diarrhea Score and Enhanced Intestinal Barrier Function in Growing Piglets

Liu

Guan

Fang

et al. 2016

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…Proteomics can provide details about the changes and comparisons in expression pattern of proteins in a specific physiological or pathological condition. Protein profiling approaches can also be used to analyze quality, origin, or adulterations of food 20 .…”

Section: X21 Omics Approaches In Foodomicsmentioning

confidence: 99%

“…However, top-down Proteomics approaches are usually limited to simple protein mixtures since multiple charged proteins generate very complex spectra. 20 .…”

Section: X21 Omics Approaches In Foodomicsmentioning

confidence: 99%

Chapter 1. Foodomics – Fundamentals, State of the Art and Future Trends

Álvarez‐Rivera¹,

Valdés²,

León³

et al. 2021

Food Chemistry, Function and Analysis

View full text Add to dashboard Cite

Foodomics is being consolidated in Food Science through the application and integration of a variety of omics tools (e.g., genomics/trascriptomics, proteomics, metabolomics) together with chemometrics and bioinformatics. Foodomics can greatly improve our understanding of the complex fooddietindividual interplay, involving different Food Science and Nutrition research areas dealing with food composition, food safety, quality and traceability issues, as well as the food impact on individual's health/illness status. Readers of the present chapter will get an overview of the fundamentals, the most recent advances and future perspectives in the different areas of Foodomics.

show abstract

“…The role of various nutrients in gene expression and regulation is considered a key in nutritional sciences. Specifically, nutritional compounds may influence gene expression at different levels including transcription [ 2 ], maturing and stability of RNAs, translation process, and post-translational modifications [ 3 , 4 ]. Additionally, the response to the dietary intake depends on the genetic background of an individual which is known as nutrigenetics [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Statistical and Machine-Learning Analyses in Nutritional Genomics Studies

et al. 2020

View full text Add to dashboard Cite

Nutritional compounds may have an influence on different OMICs levels, including genomics, epigenomics, transcriptomics, proteomics, metabolomics, and metagenomics. The integration of OMICs data is challenging but may provide new knowledge to explain the mechanisms involved in the metabolism of nutrients and diseases. Traditional statistical analyses play an important role in description and data association; however, these statistical procedures are not sufficiently enough powered to interpret the large integrated multiple OMICs (multi-OMICS) datasets. Machine learning (ML) approaches can play a major role in the interpretation of multi-OMICS in nutrition research. Specifically, ML can be used for data mining, sample clustering, and classification to produce predictive models and algorithms for integration of multi-OMICs in response to dietary intake. The objective of this review was to investigate the strategies used for the analysis of multi-OMICs data in nutrition studies. Sixteen recent studies aimed to understand the association between dietary intake and multi-OMICs data are summarized. Multivariate analysis in multi-OMICs nutrition studies is used more commonly for analyses. Overall, as nutrition research incorporated multi-OMICs data, the use of novel approaches of analysis such as ML needs to complement the traditional statistical analyses to fully explain the impact of nutrition on health and disease.

show abstract

Proteomics and Nutrition Research

Cited by 4 publications

References 60 publications

Macleaya cordataExtract Decreased Diarrhea Score and Enhanced Intestinal Barrier Function in Growing Piglets

Macleaya cordataExtract Decreased Diarrhea Score and Enhanced Intestinal Barrier Function in Growing Piglets

Chapter 1. Foodomics – Fundamentals, State of the Art and Future Trends

Statistical and Machine-Learning Analyses in Nutritional Genomics Studies

Contact Info

Product

Resources

About