Prune belly syndrome: expanding the phenotype

Smolkin, Tatiana; Soudack, Michalle; Goldstein, Israel; Sujov, Polo; Makhoul, Imad R.

doi:10.1097/mcd.0b013e328263083b

Cited by 20 publications

(16 citation statements)

References 6 publications

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“…The literature search of the PubMed database yielded 50 articles [10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61]. After title/abstract review, 22 articles were screened in full-text and included in this comprehensive review [10,11,12,13,14,15,16,17,18,19,20,21,22,23,…”

Section: Resultsmentioning

confidence: 99%

Dried Plums, Prunes and Bone Health: A Comprehensive Review

Wallace

2017

Nutrients

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The 2015–2020 Dietary Guidelines for Americans advocate for increasing fruit intake and replacing energy-dense foods with those that are nutrient-dense. Nutrition across the lifespan is pivotal for the healthy development and maintenance of bone. The National Osteoporosis Foundation estimates that over half of Americans age 50+ have either osteoporosis or low bone mass. Dried plums, also commonly referred to as prunes, have a unique nutrient and dietary bioactive profile and are suggested to exert beneficial effects on bone. To further elucidate and summarize the potential mechanisms and effects of dried plums on bone health, a comprehensive review of the scientific literature was conducted. The PubMed database was searched through 24 January 2017 for all cell, animal, population and clinical studies that examined the effects of dried plums and/or extracts of the former on markers of bone health. Twenty-four studies were included in the review and summarized in table form. The beneficial effects of dried plums on bone health may be in part due to the variety of phenolics present in the fruit. Animal and cell studies suggest that dried plums and/or their extracts enhance bone formation and inhibit bone resorption through their actions on cell signaling pathways that influence osteoblast and osteoclast differentiation. These studies are consistent with clinical studies that show that dried plums may exert beneficial effects on bone mineral density (BMD). Long-term prospective cohort studies using fractures and BMD as primary endpoints are needed to confirm the effects of smaller clinical, animal and mechanistic studies. Clinical and prospective cohort studies in men are also needed, since they represent roughly 29% of fractures, and likewise, diverse race and ethnic groups. No adverse effects were noted among any of the studies included in this comprehensive review. While the data are not completely consistent, this review suggests that postmenopausal women may safely consume dried plums as part of their fruit intake recommendations given their potential to have protective effects on bone loss.

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Section: Resultsmentioning

confidence: 99%

Dried Plums, Prunes and Bone Health: A Comprehensive Review

Wallace

2017

Nutrients

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“…The classical PBS triad of absent abdominal musculature, urinary tract ectasia and bilateral cryptorchidism belies a heterogeneous disorder with numerous phenotypic associations 9. However, PBS is a syndrome, with case reports describing myriad specific associations, including genital malformations, pulmonary hypoplasia, hemivertebrae, congenital cardiac defects and a variety of gastrointestinal manifestations 1 9.…”

Section: Discussionmentioning

confidence: 99%

“…However, PBS is a syndrome, with case reports describing myriad specific associations, including genital malformations, pulmonary hypoplasia, hemivertebrae, congenital cardiac defects and a variety of gastrointestinal manifestations 1 9. The heterogeneity of PBS has engendered proposals to either subclassify the syndrome based upon severity and phenotypic associations,10 or to expand the definition of PBS so as to capture the heterogeneity of the condition in a better manner 9. Classification of PBS along an axis of severity has not been routinely adopted and the epidemiological and aetiological implications of PBS subclassification remain incompletely understood 10…”

Section: Discussionmentioning

confidence: 99%

Pregnancy outcome in a woman with prune belly syndrome

Hillman

Garabedian²,

Wallerstein

2012

BMJ Case Reports

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SummaryPrune belly syndrome is a rare congenital syndrome that primarily affects male fetuses. Affected men are universally infertile; however, there is a paucity of information published on the reproductive potential of affected women. Pregnancy outcomes in affected women have not been described in the literature. We describe the case of pregnancy in an affected woman. Her pregnancy progressed without complication. Her fetus had no stigmata of the syndrome. Her labour and delivery were, however, complicated by a prolonged second stage of labour and need for vacuum-assisted vaginal delivery. BACKGROUND

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“…Recognition of these additional elements led Smolkin et al [5] to suggest the term prune belly association.…”

Section: Introductionmentioning

confidence: 97%

Prune belly syndrome

2011

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The majority of paediatric surgeons will encounter a patient with prune belly syndrome (PBS) only a few times in their clinical practice. There have been many opposing views in the literature regarding the pathogenesis and management of this complex condition. A detailed review was conducted using PubMed to identify key publications involving PBS. This article discusses the evolution of our understanding of the pathogenesis and diagnosis of PBS, including its typical characteristics. We describe the management options available for bilateral intra-abdominal testes, the deficient abdominal wall, the dilated urinary system and examine the evidence base used to support the current approaches employed.

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Prune belly syndrome: expanding the phenotype

Cited by 20 publications

References 6 publications

Dried Plums, Prunes and Bone Health: A Comprehensive Review

Dried Plums, Prunes and Bone Health: A Comprehensive Review

Pregnancy outcome in a woman with prune belly syndrome

Prune belly syndrome

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