Public-health risks of melamine in milk products

Chan, Emily; Griffiths, Siân; Chan, Chokwan

doi:10.1016/s0140-6736(08)61604-9

Cited by 213 publications

(118 citation statements)

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“…10 Poisonous milk powder released in 2008 affected over 294,000 children and infants, of whom approximately 54,000 were hospitalized and six died in the People's Republic of China. 11,12 Similar cases have been reported in Vietnam and Singapore. 12 MEL-contaminated infant food was also found in 2008 in the USA, 12 2010 in the People's Republic of China, 13 and again in 2013 in the USA.…”

Section: Introductionsupporting

confidence: 75%

Lateral flow test strip based on colloidal selenium immunoassay for rapid detection of melamine in milk, milk powder, and animal feed

Wang¹,

Zhi²,

Zhao³

et al. 2014

IJN

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Although high melamine (MEL) intake has been proven to cause serious health problems, MEL is sometimes illegally added to milk products and animal feed, arousing serious food safety concerns. A satisfactory method of detecting MEL in onsite or in-home testing is in urgent need of development. This work aimed to explore a rapid, convenient, and cost-effective method of identifying MEL in milk products or other food by colloidal selenium-based lateral flow immunoassay. Colloidal selenium was synthesized by L-ascorbic acid to reduce seleninic acid at room temperature. After conjugation with a monoclonal antibody anti-MEL, a test strip was successfully prepared. The detection limit of the test strip reached 150 μg/kg, 1,000 μg/kg, and 800 μg/kg in liquid milk, milk powder, and animal feed, respectively. No cross-reactions with homologues cyanuric acid, cyanurodiamide, or ammelide were found. Moreover, the MEL test strip can remain stable after storage for 1 year at room temperature. Our results demonstrate that the colloidal selenium MEL test strip can detect MEL in adulterated milk products or animal feed conveniently, rapidly, and sensitively. In contrast with a colloidal gold MEL test strip, the colloidal selenium MEL test strip was easy to prepare and more cost-efficient.

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Section: Introductionsupporting

confidence: 75%

Lateral flow test strip based on colloidal selenium immunoassay for rapid detection of melamine in milk, milk powder, and animal feed

Wang¹,

Zhi²,

Zhao³

et al. 2014

IJN

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“…1), contains 66% nitrogen by weight (Chan et al, 2008) and has the following structure shown in Fig. 1.…”

Section: Introductionmentioning

confidence: 99%

Effect of Melamine Adulteration on Body Weight, Liver and Kidney Histology and Liver Function Indices of Albino Rats

Sale¹,

Wasagu²,

Lawal³

et al. 2015

Asian J. of Biochemistry

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The effect of melamine adulteration on body weight, liver and kidney histology and liver function using feed containing 0, 4, 8, 12 and 16 mg of melamine per kg diet administered ad labium to wistar rats were studied. Kidney histology was affected at concentrations $8 mg kgG 1 by the onset of mild interstitial chronic inflammation while the liver histology of all test animals appeared normal. Results of body weight change showed significant (p<0.05) increase at the highest dosed group though, body weight increase was observed in all animals. The subchronic toxicity study on liver function parameters showed significant (p<0.05) increase in ALT activity at all doses while, total protein concentration was significantly affected (p<0.05) in the highest dosed group. Melamine should therefore, be absent from feed especially at concentrations approaching milligram quantity in order to safe guard health.

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“…[1][2][3][4] On Sept. 12, 2008, the Chinese government announced to the public that the outbreak had occurred and initiated various emergency responses, including the set-up of a high-level national coordinating group, free screening and treatment of affected children, thorough inspection of all dairy products and producers, timely release of information to the public, recalls of contaminated products, suspension of production of the contaminated milk and compensation to the families of affected children. More than 50 000 children have been hospitalized and six have died because of kidney damage.…”

mentioning

confidence: 99%

Urinary tract abnormalities in Chinese rural children who consumed melamine-contaminated dairy products: a population-based screening and follow-up study

Liu

Ren²,

Yang³

et al. 2010

Canadian Medical Association Journal

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Public-health risks of melamine in milk products

Cited by 213 publications

References 1 publication

Lateral flow test strip based on colloidal selenium immunoassay for rapid detection of melamine in milk, milk powder, and animal feed

Lateral flow test strip based on colloidal selenium immunoassay for rapid detection of melamine in milk, milk powder, and animal feed

Effect of Melamine Adulteration on Body Weight, Liver and Kidney Histology and Liver Function Indices of Albino Rats

Urinary tract abnormalities in Chinese rural children who consumed melamine-contaminated dairy products: a population-based screening and follow-up study

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