Pulmonary blastoma.
            <i>An ultrastructural study with a brief review of literature and a discussion of pathogenesis</i>

Fung, Christopher H. K.; Lo, James W.; Yonan, Theodore N.; Milloy, Frank J.; Hakami, Massih M.; Changus, George W.

doi:10.1002/1097-0142(197701)39:1<153::aid-cncr2820390126>3.0.co;2-#

Cited by 73 publications

(19 citation statements)

References 33 publications

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“…Several reports have shown that sputum analysis occasionally gives a false-positive test result as the mesenchymal tumor cells break through the bronchial epithelium and shed neoplastic cells. 13,15,16 Aspiration cytology and needle biopsy have been used to determine the nature of the tumor, 9 but the definitive diagnosis can only be made by histopathologic evaluation of a surgical biopsy. The aspiration cytology from our patient suggested neuroblastoma, but histopathologic diagnosis of the resected tumor confirmed a diagnosis of PB.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Blastoma in a Child: Report of a Case

Ishikawa¹,

Sato²,

Tsunezuka³

et al. 2001

Surgery Today

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We describe herein the case of a 2-year-old girl found to have a pulmonary blastoma (PB). The child was admitted to our hospital with the chief complaints of coughing and left-sided chest pain. On admission, a chest X-ray revealed a large mass in the left lung, which measured 10cm in diameter. Computed tomography and magnetic resonance imaging showed a marginally and heterogeneously enhanced tumor filling the left hemithorax. Pathologic findings of the fine-needle aspiration were suggestive of neuroblastoma. Subsequently, a left pneumonectomy with lymph node dissection was performed and histopathological examination confirmed that the tumor was a PB (type III). After the definitive diagnosis was made the patient received combination chemotherapy, and no evidence of recurrence has been seen in the 5 months since surgery.

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Section: Discussionmentioning

confidence: 99%

Pulmonary Blastoma in a Child: Report of a Case

Ishikawa¹,

Sato²,

Tsunezuka³

et al. 2001

Surgery Today

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“…Spencer (1961), following the former school and influenced by the peripheral development of the four tumours he had seen, felt it was logical to believe that they developed from lung mesoderm and thus should be named pulmonary blastoma. The supporters of the alternative theory of origin felt that, as they had demonstrated distinct epithelial and mesenchymal cell types on electron microscopy (McCann, Fu & Kay 1976, Fung et al 1977, the diagnosis of carcinosarcoma was more appropriate. Despite this opinion, they considered that the name pulmonary blastoma should be retained because of the distinctive clinicopathological features of tumours with and without embryonal differentiation.…”

Section: Embryology a N D C E L L O R I G I Nmentioning

confidence: 99%

“…1976). It is held that the cell lines found in this pulmonary tumour are quite separate and transformations from one to the other do not occur (McCann et al 1976, Fung et al 1977. This finding is disputed by others (Stackhouse, Harrison andEllis 1969, Davis et al 1972).…”

Section: Embryology a N D C E L L O R I G I Nmentioning

confidence: 99%

Pulmonary blastoma, a true congenital neoplasm*

Ashworth¹

1983

Histopathology

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An infant, after a difficult delivery, had X-ray shadowing in the right lung. After 32 days sudden death occurred, a pulmonary blastoma being found at autopsy. The controversy over whether this tumour is a blastoma or a carcinosarcoma is discussed and arguments are advanced for acceptance of the designation pulmonary blastoma when the tumour occurs in infancy and childhood. When the equivalent tumour occurs in adults with or without the addition of areas of carcinoma and/or sarcoma, the title 'mixed tumour of lung' should replace the term carcinosarcoma.

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“…Spencer described four further cases in 1961 and renamed it "pulmonary blastoma." This type of neoplasm has recently been reviewed by Karcioglu and Someren (1974) and Fung et al (1977). About 40 cases have been reported at the time of writing.…”

Section: Pathologymentioning

confidence: 99%

“…Solid nests and cords or rosettes may also be seen (Marsden and Scholtz, 1976;Fung et al, 1977). Mitoses are often numerous.…”

Section: Pathologymentioning

confidence: 99%

Mixed malignant tumour of the lung.

Edwards¹,

Saunders²,

Collins³

1979

Thorax

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ABsTRAcr A mixed malignant tumour of the lung intermediate in type between pulmonary blastoma and carcinosarcoma is described. The epithelial component consisted of squamous carcinoma, undifferentiated carcinoma, and clefts lined by bland epithelial cells. The supporting stroma was composed of pleomorphic sarcoma, fibrosarcoma, chondrosarcoma, osteosarcoma, and indeterminate mesenchymal tissue. The tumour was removed surgically, but the patient died postoperatively with rapidly developing multiple bony and soft tissue metastases. Subcutaneous metastases showed the appearance of poorly differentiated pleomorphic sarcoma. Published reports of mixed malignant lung tumours are reviewed.Lung neoplasms that contain malignant connective tissue and epithelial elements may be classified into three subgroups-namely, carcinosarcomas, pulmonary blastomas, and "transitional" tumours (Davis et al, 1972). Carcinosarcomas are the least rare, and consist of islands of welldifferentiated squamous carcinoma or adenocarcinoma in a stroma of malignant spindle cells, which sometimes shows osseous or chondroid foci. They were first recognised in the early years of this century (Kika, 1908;Saltykow, 1914). Pulmonary blastomas (Spencer, 1961) or embryomas (Barnard, 1952) have a remarkable resemblance to fetal lung even at an ultrastructural level, with epithelial islands and tubules in a pleomorphic spindle cell stroma. The transitional variant, which shows the features of both blastoma and carcinosarcoma, was first described by Davis et al (1972). We describe a case of the latter type of tumour in which there was a wide spectrum of mesenchymal and epithelial malignancy. The pathology, histogenesis, and classification of mixed malignant pulmonary tumours is discussed, and the relevant published reports are reviewed. Case reportA 61-year-old confectioner presented in August 1977 with an eight-week history of non-productive cough, ankle swelling, and weight loss. He had had no serious illnesses in the past, and smoked two ounces (56 g) of pipe tobacco a week. He had mild ankle oedema and finger clubbing. A few crackles were heard at the left base. A chest radiograph showed a large, well-defined mass in the left lower zone and prominence of the left hilum Results of haematological and biochemical tests were normal. At bronchoscopy there was narrowing of the main lower lobe bronchus on the left side. A biopsy showed normal bronchial mucosa and cartilage.At thoracotomy four weeks later a mass was found occupying most of the left lower lobe. Lymph nodes at the hilum and in the pulmonary ligament were enlarged. A routine left pneumonectomy was carried out.Eight days after operation the patient began to complain of pain in the left thigh. A hard, tender, fusiform swelling was found in the quadriceps and a hard, rounded nodule over the lower end of the tibia. Over the next seven days several nodules appeared in the subcutaneous tissues of the lower legs and left upper chest. The nodules in the legs appeared to be fixed to underlying bone, and ra...

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Pulmonary blastoma. An ultrastructural study with a brief review of literature and a discussion of pathogenesis

Cited by 73 publications

References 33 publications

Pulmonary Blastoma in a Child: Report of a Case

Pulmonary Blastoma in a Child: Report of a Case

Pulmonary blastoma, a true congenital neoplasm*

Mixed malignant tumour of the lung.

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