Pulmonary Function Tests and Thyroid Hormone Concentrations in Patients with Chronic Obstructive Pulmonary Disease

Okutan, Oğuzhan; Kartaloğlu, Zafer; M, Onde; Bozkanat, Erkan; Kunter, Erdoğan

doi:10.1159/000076950

Cited by 29 publications

(31 citation statements)

References 8 publications

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“…1). The decreased T 3 and TSH and the increased rT 3 serum levels observed in this model of acute inflammatory lung injury are in agreement with those seen in the clinical setting of critical illness in patients with acute lung injury (ALI) and in animal models of acute illness (27)(28)(29)(30)(31)(32)(33)(34).…”

Section: Resultssupporting

confidence: 83%

Role of type 2 deiodinase in response to acute lung injury (ALI) in mice

Barca-Mayo

Liao

DiCosmo

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

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Thyroid hormone (TH) metabolism, mediated by deiodinase types 1, 2, and 3 (D1, D2, and D3) is profoundly affected by acute illness. We examined the role of TH metabolism during ventilator-induced lung injury (VILI) in mice. Mice exposed to VILI recapitulated the serum TH findings of acute illness, namely a decrease in 3,5,3′-triiodothyronine (T 3 ) and thyroid-stimulating hormone and an increase in reverse T 3 . Both D2 immunoreactivity and D2 enzymatic activity were increased significantly. D1 and D3 activity did not change. Using D2 knockout (D2KO) mice, we determined whether the increase in D2 was an adaptive response. Although similar changes in serum TH levels were observed in D2KO and WT mice, D2KO mice exhibited greater susceptibility to VILI than WT mice, as evidenced by poorer alveoli integrity and quantified by lung chemokine and cytokine mRNA induction. These data suggest that an increase in lung D2 is protective against VILI. Similar findings of increased inflammatory markers were found in hypothyroid WT mice exposed to VILI compared with euthyroid mice, indicating that the lungs were functionally hypothyroid. Treatment of D2KO mice with T 3 reversed many of the lung chemokine and cytokine profiles seen in response to VILI, demonstrating a role for T 3 in the treatment of lung injury. We conclude that TH metabolism in the lung is linked to the response to inflammatory injury and speculate that D2 exerts its protective effect by making more TH available to the injured lung tissue.nonthyroidal illness | euthyroid sick | reverse triiodothyronine | bronchial alveolar lavage | sepsis T hyroid hormone [TH, here denoting the active hormone 3,5,3′-triiodothyronine (T 3 ) and its precursor thyroxine (T 4 )] is necessary for the normal development and function of virtually every vertebrate tissue. Although the thyroid gland is predominantly responsible for the production and release of T 4 , the cellular bioavailability of the active T 3 depends on TH-specific transporters and tissue TH metabolism. Metabolism of TH is regulated by three iodothyronine deiodinases. Both type 1 (D1) and type 2 (D2) deiodinases serve to generate bioactive T 3 by outer-ring deiodination of T 4 . D2 has a major role in the intracellular generation of the active TH in mouse; the role of the D1, with its broad substrate specificity and ability to carry out both outer-and inner-ring deiodination, is less well understood. In contrast, type 3 iodothyronine deiodinase (D3) inactivates TH by inner-ring deiodination of T 4 to reverse T 3 (3′,5,3-triiodothyronine; rT 3 ) and T 3 to 3,3′-diiodothyronine (T 2 ), both biologically inactive compounds (1).Studies have elucidated the dynamic effects of TH action on brain, bone, liver (2-5), and maturation of the fetal lung (6, 7), but little is known regarding the role of TH in adult lung physiology. Until now, evidence suggesting that TH influences adult lung physiology has been indirect and based on the presence of TH receptors (8), deiodinases (9-12), and measured TH concentrations (10,13,14) i...

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Section: Resultssupporting

confidence: 83%

Role of type 2 deiodinase in response to acute lung injury (ALI) in mice

Barca-Mayo

Liao

DiCosmo

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

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“…They did not find any correlation between arterial blood gas measurement and thyroid hormone concentrations in patients with COPD. Okutan et al (12) found that level of FT3 was higher in stable COPD than control group. They reported that there was negative correlation between pulmonary function tests and PaO 2 or FT3.…”

Section: Discussionmentioning

confidence: 95%

Thyroid Hormon Levels in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease

2007

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“…Further studies are needed to verify if impaired thyroid function really increases the risk of COPD exacerbation and if proper hormonal treatment would impact the clinical outcome. Authors of other studies reported on lower spirometry parameters in patients without clinically diagnosed hypothyroidism, but with low values of thyroid hormones, that still remained within normal limits [14]. It is of note that the muscle weakness, caused by hypothyroidism, is reversible after treatment [33].…”

Section: Hypothyroidismmentioning

confidence: 94%

“…There is a growing evidence that thyroid gland function may be disturbed in COPD patients [2,5,[13][14][15][16]. Some studies show that thyroid diseases are more frequent among patients with COPD.…”

Section: Wwwjournalsviamedicaplmentioning

confidence: 99%

“…In hypothyroidism mean inspiratory pressure (MIP) and mean expiratory pressure (MEP) are decreased [2,31], supposedly due to decreased respiratory muscle strength [33]. The association of free T3 (fT3) level with arterial blood gases and pulmonary function parameters (vital capacity [VC] or forced vital capacity [FVC], FEV 1 , peak expiratory flow [PEF]) has been demonstrated [14]. Another study also confirmed lower values of MEP in COPD patients with hypothyroidism than in those without this condition [31].…”

Section: Hypothyroidismmentioning

confidence: 99%

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Thyroid Gland in Chronic Obstructive Pulmonary Disease

Miłkowska-Dymanowska

Białas

Laskowska

et al. 2017

Advances in Respiratory Medicine

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The risk of chronic obstructive pulmonary disease (COPD), as well as thyroid diseases increases with age. COPD is a common systemic disease associated with chronic inflammation. Many endocrinological disorders, including thyroid gland diseases are related to systemic inflammation. Epidemiological studies suggest that patients with COPD are at higher risk of thyroid disorders. These associations are not well-studied and thyroid gland diseases are not included on the broadly acknowledged list of COPD comorbidities. They may seriously handicap quality of life of COPD patients. Unfortunately, the diagnosis may be difficult, as many signs are masked by the symptoms of the index disease. The comprehension of the correlation between thyroid gland disorders and COPD may contribute to better care of patients. In this review, we attempt to revise available literature describing existing links between COPD and thyroid diseases.

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Pulmonary Function Tests and Thyroid Hormone Concentrations in Patients with Chronic Obstructive Pulmonary Disease

Cited by 29 publications

References 8 publications

Role of type 2 deiodinase in response to acute lung injury (ALI) in mice

Role of type 2 deiodinase in response to acute lung injury (ALI) in mice

Thyroid Hormon Levels in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Thyroid Gland in Chronic Obstructive Pulmonary Disease

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