Pure Testicular Seminoma Relapsing Late with Somatic Type Malignancy

Dieckmann, Klaus‐Peter; Anheuser, Petra; Gehrckens, Ralf; Wilczak, Waldemar; Sauter, Guido; Höflmayer, Doris

doi:10.1155/2017/2457023

Cited by 3 publications

(3 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Histologically, these tumors resemble typical primary neoplasms. However, with the use of fluorescence in situ hybridization (FISH), isochromosome 12p can often be identified, confirming germ cell tumor origin despite morphologic dissimilarity [5]. Surgical resection is favored as primary therapy in those presenting with germ cell tumors transformed to an alternate malignancy, especially in patients with localized disease [6].…”

Section: Discussionmentioning

confidence: 99%

An Unusual Transformation of a Nonseminomatous Germ Cell Tumor to Adenocarcinoma

Leibovitch¹,

Ramadas²,

Fudym³

et al. 2019

J Med Cases

View full text Add to dashboard Cite

Transformation of germ cell tumor to an alternate malignancy is rare; and it is believed to be secondary to teratomatous elements of the initial tumor surviving chemotherapy and subsequently proliferating. Here, we describe a patient with transformation of a nonseminomatous germ cell tumor to adenocarcinoma. A 55-year-old male with history of nonseminomatous germ cell tumor of the left testicle, previously resected, followed by four cycles of BEP chemotherapy, on active surveillance, presented nearly 20 years later with nausea and rising alpha-fetoprotein levels. Computed tomography (CT) abdomen revealed bulky retrocrural lymphadenopathy with increased fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET) scan. Biopsy revealed metastatic adenocarcinoma, staining strongly positive for SALL4 and CDX2, with focal rare positivity for CK20 in the tumor cells, consistent with germ cell origin. FOL-FOX therapy was therefore initiated. This is one of few documented cases showing transformation of nonseminomatous germ cell tumor to adenocarcinoma, for which surgical resection is favored as primary therapy. However, aggressive adjuvant chemotherapy may be considered and should be directed towards the most aggressive found histology.

show abstract

Section: Discussionmentioning

confidence: 99%

An Unusual Transformation of a Nonseminomatous Germ Cell Tumor to Adenocarcinoma

Leibovitch¹,

Ramadas²,

Fudym³

et al. 2019

J Med Cases

View full text Add to dashboard Cite

show abstract

“…The late-relapse SM from a stage I seminoma in case 2 is surprising because most SMs develop after systemic chemotherapy for disseminated NSGCT. There has been only one case report of SMs developed from pure seminoma [ 6 ]. In that case, the patient experienced a late relapse at nine years after he was cured from testicular seminoma clinical stage IIc by orchiectomy and cisplatin-based chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Two cases of somatic-type malignancy as a very late relapse of testicular cancer successfully managed by surgical resection

Washino

Konishi

Saito

et al. 2017

Journal of Surgical Case Reports

View full text Add to dashboard Cite

A late-relapse germ cell tumor might contain malignant non-germ cell tumors, known as ‘somatic-type malignancy (SM)’. The development of a secondary SM is rare, and this phenomenon remains poorly understood. Case 1 developed lung metastasis 13 years after chemotherapy followed by retroperitoneal lymph node dissection for stage IIA non-seminoma. The tumor increased in size after chemotherapy. The patient underwent a pneumonectomy. Pathology revealed an adenocarcinoma with immature teratoma. The patient has experienced no relapse for 9 years. Case 2 developed a pelvic tumor after 10 years of surveillance for stage I seminoma. The tumor increased in size after chemotherapy. The patient underwent pelvic tumor resection with cystectomy. Pathology revealed a mature teratoma with SMs consisting of sarcoma and adenocarcinoma. The patient has experienced no relapse for 6 months. Surgical resection played a major role in the treatment of very late-relapse germ cell tumors with SM.

show abstract

“…In this case, it will be realized if spermatozoa are produced in the testicles, but are not present in the sperm. When examination of the testes by palpation or ultrasound has revealed the presence of a mass, the biopsy can be used to determine the cause of this testicular mass, whether it is a cancerous mass or not [13].…”

Section: Introductionmentioning

confidence: 99%

Biopsy and vascularization: testicular tissue removal and prevention of hemorrhagies related to the main vessels

Deh¹,

Ajl²,

Mf³

et al. 2018

J Histol Histopathol

View full text Add to dashboard Cite

Purpose: the objective of the work is to determine the testicular regions favorable for the realization of a testicular biopsy without damaging the important vessels. Material and Methods: 8 left and right testes were collected from 3 immature Wistar rats and 1 adult control, aged 15, 25 and 40 days for the young rats and 7 months for the adult. The testes were taken under inhalation anesthesia. The testes were examined by eye and the images were obtained from a digital camera. Results: Results showed that the testicular (or spermatic) artery with a large caliber had a subcapsular arrangement. It was tortuous and followed the anterior edge of the testicle from the upper pole to the lower pole. As that vessel passed along this place it formed an arterial handle and ascended along the posterior edge. The arrangement of this artery was identical for all populations of rats. Very small vessels were observed beneath the internal surface of the albuginea of the testis mainly from the lateral areas of the testis. They had transverse, horizontal and oblique directions and which intensified with the age of the animals. Conclusion: Anatomically, the results of this study highlight the situation and caliber variability of the superficial vessels of the testis and the importance of the testicular artery. Clinically, they could be useful for testicular biopsy, we suggest that it be practiced away from the large vessels, that is to say in the lateral areas of the testicle.

show abstract

Pure Testicular Seminoma Relapsing Late with Somatic Type Malignancy

Cited by 3 publications

References 34 publications

An Unusual Transformation of a Nonseminomatous Germ Cell Tumor to Adenocarcinoma

An Unusual Transformation of a Nonseminomatous Germ Cell Tumor to Adenocarcinoma

Two cases of somatic-type malignancy as a very late relapse of testicular cancer successfully managed by surgical resection

Biopsy and vascularization: testicular tissue removal and prevention of hemorrhagies related to the main vessels

Contact Info

Product

Resources

About