QT interval effects of Cisapride in the clinical setting

Wang, S.H; Lin, Cheng-Yao; Huang, Tzu‐Ling; Wu, Wen-Ju; Chen, C.C; Tsai, Shu-Ming

doi:10.1016/s0167-5273(01)00485-5

Cited by 33 publications

(16 citation statements)

References 14 publications

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“…In addition, they improve gastric accommodation and ameliorate impaired visceral sensation[21,22]. However, they have been withdrawn from the market due to their side effects on cardiac rhythmicity (related to prolongation of QT intervals)[23]. …”

Section: Discussionmentioning

confidence: 99%

Effects of Hwangryunhaedok-tang on gastrointestinal motility function in mice

Kim

Lee

et al. 2017

WJG

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AIMTo investigate the effects of Hwangryunhaedok-tang (HHT) on gastrointestinal (GI) motility in mice.METHODSThe effects of a boiling water extract of HHT (HHTE) on GI motility were investigated by calculating percent intestinal transit rates (ITR%) and gastric emptying (GE) values using Evans Blue and phenol red, respectively, in normal mice and in mice with experimentally induced GI motility dysfunction (GMD). In addition, the effects of the four components of HHT, that is, Gardeniae Fructus (GF), Scutellariae Radix (SR), Coptidis Rhizoma (CR), and Phellodendri Cortex (PC), on GI motility were also investigated.RESULTSIn normal ICR mice, ITR% and GE values were significantly and dose-dependently increased by the intragastric administration of HHTE (0.1-1 g/kg). The ITR% values of GMD mice were significantly lower than those of normal mice, and these reductions were significantly and dose-dependently inhibited by HHTE (0.1-1 g/kg). Additionally, GF, CR, and PC dose-dependently increased ITR% and GE values in normal and GMD mice.CONCLUSIONThese results suggest that HHT is a novel candidate for the development of a gastroprokinetic agent for the GI tract.

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Section: Discussionmentioning

confidence: 99%

Effects of Hwangryunhaedok-tang on gastrointestinal motility function in mice

Kim

Lee

et al. 2017

WJG

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“…28 Both antiarrhythmic and nonantiarrhythmic drugs affect the QTc interval and QT dispersion ( Table 3). [29][30][31][32][33][34][35][36][37][38][39] Antiarrhythmic drug classes Ia (quinidine and disopyramide) 29,40,41 and Ic (propafenone) 42 have been shown to increase QT dispersion. In one study, three of 26 patients with quinidine-associated torsade de pointes had increases in QT dispersion of more than 50% from baseline.…”

Section: Discussionmentioning

confidence: 99%

Effects of Methadone on QT-Interval Dispersion

et al. 2005

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“…Cisapride was shown to promote esophageal peristalsis, augment lower esophageal sphincter pressure, and accelerate gastric emptying[33]. However, the use of this drug is now restricted due to serious cardiac arrhythmias related to a prolonged QT interval[34]. Mosapride, a selective 5-HT 4 agonist, is available as a prokinetic agent in a number of Asian countries, but the efficacy data are contradictory[35].…”

Section: Discussionmentioning

confidence: 99%

Effects of Lizhong Tang on gastrointestinal motility in mice

Lee

Park

et al. 2016

WJG

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AIMTo investigate the effects of Lizhong Tang, a traditional Chinese medicine formula, on gastrointestinal motility in mice.METHODSThe in vivo effects of Lizhong Tang on GI motility were investigated by measuring the intestinal transit rates (ITRs) and gastric emptying (GE) values in normal mice and in mice with experimentally induced GI motility dysfunction (GMD).RESULTSIn normal ICR mice, the ITR and GE values were significantly and dose-dependently increased by Lizhong Tang (ITR values: 54.4% ± 1.9% vs 65.2% ± 1.8%, P < 0.01 with 0.1 g/kg Lizhong Tang and 54.4% ± 1.9% vs 83.8% ± 1.9%, P < 0.01 with 1 g/kg Lizhong Tang; GE values: 60.7% ± 1.9% vs 66.8% ± 2.1%, P < 0.05 with 0.1 g/kg Lizhong Tang and 60.7% ± 1.9% vs 72.5% ± 1.7%, P < 0.01 with 1 g/kg Lizhong Tang). The ITRs of the GMD mice were significantly reduced compared with those of the normal mice, which were significantly and dose-dependently reversed by Lizhong Tang. Additionally, in loperamide- and cisplatin-induced models of GE delay, Lizhong Tang administration reversed the GE deficits.CONCLUSIONThese results suggest that Lizhong Tang may be a novel candidate for development as a prokinetic treatment for the GI tract.

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QT interval effects of Cisapride in the clinical setting

Cited by 33 publications

References 14 publications

Effects of Hwangryunhaedok-tang on gastrointestinal motility function in mice

Effects of Hwangryunhaedok-tang on gastrointestinal motility function in mice

Effects of Methadone on QT-Interval Dispersion

Effects of Lizhong Tang on gastrointestinal motility in mice

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