Quantification of acetaminophen (paracetamol) in human plasma and urine by stable isotope-dilution GC–MS and GC–MS/MS as pentafluorobenzyl ether derivative

Trettin, Arne; Zoerner, Alexander A.; Böhmer, Anke; Gutzki, Frank‐Mathias; Stichtenoth, Dirk O.; Jordan, Jens; Tsikas, Dimitrios

doi:10.1016/j.jchromb.2011.06.012

Cited by 51 publications

(21 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In recent years, a lot of research studies have attempted to focus on the ACTM analysis using various traditional determination techniques such as capillary electrophoresis [8], spectrophotometry [9], high performance liquid chromatography [10], gas chromatographymass spectrometry [11], flow injection chemiluminescence [12]. Although sensitive detections could be achieved by using such techniques but they have required expensive and sophisticated instruments with multi-step sample preparations as well as complicated analysis procedures [13].…”

Section: Introductionmentioning

confidence: 99%

Cauliflower‐like Platinum Particles Decorated Reduced Graphene Oxide for Sensitive Determination of Acetaminophen

et al. 2019

View full text Add to dashboard Cite

Over the past years, the development of electrochemical sensing platforms for the sensitive detection of drug molecules have received great interests. In this research study, we introduced cauliflower‐like platinum particles decorated reduced graphene oxide modified glassy carbon electrode (Pt−RGO/GCE) as an electrochemical sensing platform for highly sensitive determination of acetaminophen (ACTM). The sensor was prepared via a simple and environmentally friendly two‐step electrodeposition method at room temperature. The combination of conductive RGO nanosheets and unique structured Pt particles (average 232 nm in diameter) provided an efficient interface with large effective surface area which greatly facilitated the electron transfer of ACTM. The experimental conditions that might affect the drug detection were studied in detail and optimized for best performance. The Pt−RGO/GCE was able to detect ACTM up to the limit of 2.2 nM with a linear concentration range from 0.01 to 350 μM. With its high reproducibility, excellent stability and selectivity, the as‐fabricated sensor was successfully applied to the ACTM content measurement in commercial tablets.

show abstract

Section: Introductionmentioning

confidence: 99%

Cauliflower‐like Platinum Particles Decorated Reduced Graphene Oxide for Sensitive Determination of Acetaminophen

et al. 2019

View full text Add to dashboard Cite

show abstract

“…It is a major component in numerous cold and flu preparations also in combination with nonsteroidal anti‐inflammatory drugs and opioid analgesics (Sweetman, ). Surveying the literature revealed that PAR was determined in biological fluids either individually or in combination with other drugs by various analytical methods (Abro, Memon, Bhanger, Perveen, & Kandhro, ; Celma, Allue, Prunonosa, Peraire, & Obach, ; Farid & Abdelaleem, ; Gicquel, Aubert, Lepage, Fromenty, & Morel, ; Hairin et al, ; Hewavitharana, Lee, Dawson, Markovich, & Shaw, ; Li et al, ; Liao et al, ; Locatelli et al, ; Lou, Yuan, Ruan, & Jiang, ; Ophelia, Sherry, & Moses, ; Trettin et al, ; Zhu, Ding, Guo, Yang, & Wen, ).…”

Section: Introductionmentioning

confidence: 99%

“…& Jiang, 2010; Ophelia, Sherry, & Moses, 2000;Trettin et al, 2011;Zhu, Ding, Guo, Yang, & Wen, 2007). CXZ [5-chloro-2(3H)-benzoxazolone] is a skeletal muscle relaxant.…”

mentioning

confidence: 99%

Liquid chromatography–tandem MS/MS method for simultaneous quantification of paracetamol, chlorzoxazone and aceclofenac in human plasma: An application to a clinical pharmacokinetic study

Mohamed

Hegazy

Elshahed

et al. 2018

Biomedical Chromatography

View full text Add to dashboard Cite

A facile, fast and specific method based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the simultaneous quantitation of paracetamol, chlorzoxazone and aceclofenac in human plasma was developed and validated. Sample preparation was achieved by liquid-liquid extraction. The analysis was performed on a reversed-phase C HPLC column (5 μm, 4.6 × 50 mm) using acetonitrile-10 mM ammonium formate pH 3.0 (65:35, v/v) as the mobile phase where atrovastatin was used as an internal standard. A very small injection volume (3 μL) was applied and the run time was 2.0 min. The detection was carried out by electrospray positive and negative ionization mass spectrometry in the multiple-reaction monitoring mode. The developed method was capable of determining the analytes over the concentration ranges of 0.03-30.0, 0.015-15.00 and 0.15-15.00 μg/mL for paracetamol, chlorzoxazone and aceclofenac, respectively. Intraday and interday precisions (as coefficient of variation) were found to be ≤12.3% with an accuracy (as relative error) of ±5.0%. The method was successfully applied to a pharmacokinetic study of the three analytes after being orally administered to six healthy volunteers.

show abstract

“…[2] Most recent methods for paracetamol determination are chromatographic in nature. [3,4] HPLC and GC methods have good accuracy and specificity but they are time consuming, technically demanding, and require the use of costly, highly specialized instruments.…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric Determination of Paracetamol by Reduction of 18-Molybdo-2-Phosphate Heteropoly Anion

Al-Shwaiyat¹

2013

JJC

View full text Add to dashboard Cite

A very simple, rapid and sensitive spectrophotometric method for paracetamol assay in pharmaceuticals based on the reduction of 18-molybdo-2-phosphate heteropoly complex was developed. Reaction of 18-molybdo-2-phosphate with paracetamol is very fast at room temperature. The stoichiometry of the reaction is 1:1. The molar absorptivity calculated for paracetamol was equal to that for heteropoly blue formed in the studied reaction and was of 1.15×10 4 l mol-1 cm-1 at 820 nm. Beer`s law was followed for paracetamol concentrations from 0.3 to 7.5 µg ml-1 (l = 1 cm). The detection limit of the method was 0.03 µg ml-1 (l = 5 cm), and a relative standard deviation did not exceed 2.5 %. The method was successfully applied to the determination of paracetamol in pharmaceuticals.

show abstract

Quantification of acetaminophen (paracetamol) in human plasma and urine by stable isotope-dilution GC–MS and GC–MS/MS as pentafluorobenzyl ether derivative

Cited by 51 publications

References 24 publications

Cauliflower‐like Platinum Particles Decorated Reduced Graphene Oxide for Sensitive Determination of Acetaminophen

Cauliflower‐like Platinum Particles Decorated Reduced Graphene Oxide for Sensitive Determination of Acetaminophen

Liquid chromatography–tandem MS/MS method for simultaneous quantification of paracetamol, chlorzoxazone and aceclofenac in human plasma: An application to a clinical pharmacokinetic study

Spectrophotometric Determination of Paracetamol by Reduction of 18-Molybdo-2-Phosphate Heteropoly Anion

Contact Info

Product

Resources

About