Quantitative analysis of tumor-associated tissue eosinophilia in different histological grades of oral squamous cell carcinoma

Bankur, Rashmi; Rodrigues, Charlotte; Anjaly, D; Gopinathan, Pillai Arun; Bankur, Praveen Kumar

doi:10.4103/0970-9290.195612

Cited by 10 publications

(2 citation statements)

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“…With regard to invasive carcinoma, our study showed a significant increase in tissue eosinophilia between the OIN-3 or microinvasive OSCC groups and the invasive OSCC group (Figure 1), which is in agreement with the findings in the literature that correlate eosinophils to tumour invasion (Bankur et al, 2016;Debta et al, 2016;Falconieri et al, 2008;Tostes Oliveira et al, 2009). Interestingly, the nonmetastatic OSCC group showed a greater eosinophil count than the metastatic OSCC group although not significantly different.…”

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confidence: 91%

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Tissue eosinophilia in oral intraepithelial neoplasia as a probable indicator of invasion

et al. 2018

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Section: Discussionsupporting

confidence: 91%

“…Tumour-associated tissue eosinophilia has been reported in diverse sites (Spiegel, 2002;Spiegel, Ashraf, & Brooks, 2002;Szalayova et al, 2016) including the head and neck region Bankur, Rodrigues, Anjaly, Gopinathan, & Bankur, 2016;Said et al, 2005;Tadbir, Ashraf, & Sardari, 2009). Its exact function, however, remains unclear.…”

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confidence: 99%

Tissue eosinophilia in oral intraepithelial neoplasia as a probable indicator of invasion

et al. 2018

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Comprehensive bioinformatics analysis combined with experimental validation to screen biomarkers for malignant transformation of oral leukoplakia

Qiu

Gao

et al. 2023

Genomics

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The role of tumour-associated tissue eosinophilia as a prognostic indicator in head and neck squamous cell carcinoma

Sharma

Salaria

Kumar

et al. 2021

Egypt J Otolaryngol

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Background Eosinophils are bone marrow-derived granulocytes known to have an imperative role in tissue inflammation. The mechanism of tumour-associated tissue eosinophilia (TATE) in head and neck cancers is however not well understood, and its role as a prognosticator is under evaluation. The aim of this study was to evaluate the association of TATE with factors associated with head and neck cancer and to assess its role as a prognostic marker in such patients. Results 102 males and 24 females comprised the study population, and 34.9% of which were in the age group of 41 to 50 years. Amongst these 126 patients, most (37.3%) presented in stage III followed by stage IV (28.6%). 29.4% had well-differentiated SCC, 55.6% had moderately differentiated SCC, and 15% were diagnosed with poorly differentiated SCC. 42.8% had TATE grade II, followed by grade III (29.4%) and grade I (27.8%). Correlation studies showed that factors significantly associated with TATE were age, site and tumour differentiation. While 45.7% poorly differentiated tumours showed grade I eosinophilia, 51.4% of well-differentiated tumours had grade III TATE. Conclusions TATE showed a highly significant association with tumour differentiation, suggestive of eosinophils partaking a tumouricidal role. This association may be utilised as a convenient early prognosticator for head and neck cancers and should be made a regular feature of biopsy reports. Furthermore, it may be utilised in planning and adopting appropriate treatment modalities in malignancies predicted to have an aggressive course.

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Quantitative analysis of tumor-associated tissue eosinophilia in different histological grades of oral squamous cell carcinoma

Abstract: Tumor-associated tissue eosinophil count is higher in WDSCC as compared to moderate and PDSCC.

Cited by 10 publications

References 1 publication

Tissue eosinophilia in oral intraepithelial neoplasia as a probable indicator of invasion

Tissue eosinophilia in oral intraepithelial neoplasia as a probable indicator of invasion

Comprehensive bioinformatics analysis combined with experimental validation to screen biomarkers for malignant transformation of oral leukoplakia

The role of tumour-associated tissue eosinophilia as a prognostic indicator in head and neck squamous cell carcinoma

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