Quercetin, a flavonoid with anti-inflammatory activity, suppresses the development of abdominal aortic aneurysms in mice

Wang, Lian; Wang, Bo; Li, Hao; Lu, Huchen; Qiu, Fang; Xiong, Lei; Xu, Yanhui; Wang, Gaoming; Liu, Xiaolong; Wu, Haiwei; Hua, Jing

doi:10.1016/j.ejphar.2012.06.018

Cited by 65 publications

(36 citation statements)

References 45 publications

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“…The mice were randomly assigned to one of four groups (n=15 in each group): Vehicle treatment plus sham operation control (VC), vehicle treatment plus AAA (VA), quercetin treatment plus AAA (QA) and quercetin treatment plus sham operation control (QC). AAA was induced in the infrarenal abdominal aorta (age, 8 weeks) by periaortic application of CaCl 2 , as previously described (16). NaCl (0.9%) was substituted for CaCl 2 in sham operation animals.…”

Section: Methodsmentioning

confidence: 99%

“…Activator protein (AP)-1 DNA-binding activities were analyzed using Gel Shift Assay systems (Promega Corporation, Madison, WI, USA), according to the instructions previously described (16). Briefly, the AP-1 consensus oligonucleotide probe (5′-CGC TTG ATG AGT CAG CCG GAA-3′) was end-labeled with [γ- 32 P]-ATP (Furui Biotech, Beijing, China).…”

Section: Methodsmentioning

confidence: 99%

“…It is also reported that quercetin in vitro inhibits the production of O 2 •− in the rat aorta and decreases protein expression of the NADPH oxidase subunit, p47phox (14,15). A previous study from our research group indicated that quercetin treatment inhibits inflammation and prevents CaCl 2 -induced aneurysmal dilation in a mouse AAA model (16). The present study was designed to test the hypothesis that an antioxidative mechanism is also involved in the protection afforded by quercetin.…”

Section: Introductionmentioning

confidence: 97%

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Quercetin reduces oxidative stress and inhibits activation of c-Jun N-terminal kinase/activator protein-1 signaling in an experimental mouse model of abdominal aortic aneurysm

Wang

Cheng

et al. 2013

Molecular Medicine Reports

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Oxidative stress is becoming increasingly linked to the pathogenesis of abdominal aortic aneurysms (AAAs). The antioxidant activity of flavonoids has attracted attention for their possible role in the prevention of cardiovascular diseases. The purpose of this study was to determine whether an antioxidant mechanism is involved in the aneurysm formation inhibitory effect afforded by quercetin. Male C57/BL6 mice received quercetin continuously from 2 weeks prior to and 6 weeks following the AAA induction with extraluminal CaCl2. Quercetin treatment decreased AAA incidence and inhibited the reactive oxygen species generation, nitrotyrosine formation and lipid peroxidation production in the aortic tissue during AAA development. In addition, quercetin-treated mice exhibited significantly lower expression of the p47phox subunit of nicotinamide adenine dinucleotide phosphate oxidase and inducible nitric oxide synthase, as well as coordinated downregulation of manganese-superoxide dismutase activities and glutathione peroxidase (GPx)-1 and GPx-3 expression. Quercetin also blunted the expression of c-Jun N-terminal kinase (JNK) and phospho-JNK and, in addition, diminished activation of the activator protein (AP)-1 transcription factor. Gelatin zymography showed that quercetin eliminated matrix metalloproteinase (MMP)-2 and MMP-9 activation during AAA formation. In conclusion, the inhibitory effects of quercetin on oxidative stress and MMP activation, through modulation of JNK/AP-1 signaling, may partly account for its benefit in CaCl2-induced AAA.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

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Quercetin reduces oxidative stress and inhibits activation of c-Jun N-terminal kinase/activator protein-1 signaling in an experimental mouse model of abdominal aortic aneurysm

Wang

Cheng

et al. 2013

Molecular Medicine Reports

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“…However, quercetin has also been reported for a reduction in cardiovascular endangering factors including fibrinogen and human C-reactive protein in human transgenic mice [29]. Moreover, in vivo study in mice reported that due to its antiinflammatory effect quercetin is also capable of preventing calcium chloride induced abdominal aortic aneurism [30].…”

Section: Cardiovascular Protectionmentioning

confidence: 99%

“…Antioxidant activity [4], [5], [6], [7], [8] [16], [17], [18], [19], [20], [21], [22] Anticancer activity [2], [23], [24], [25], [26] Cardiovascular protection [4], [27], [28], [29], [30] Antimicrobial activity [31], [32], [33] Anti-inflammatory activity [34], [35], [36], [37], [38], [39] Hepatoprotective activity [40], [41], [42] …”

Section: Pharmacological Property Referencesmentioning

confidence: 99%

Pharmacological Applications of Quercetin and its Derivatives: A Short Review

Maalik¹,

Fa²,

Mumtaz³

et al. 2014

Trop. J. Pharm Res

125

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Quercetin (3,3ʹ,4ʹ,5,7-pentahydroxyl- flavone) is a flavonol, and it belongs to a class of plant secondary metabolites known as flavonoids. It is present in man's daily diet and is known for biological activities such as antioxidant, antiviral, anticancer, antimicrobial, anti-inflammatory and many more. Quercetin has been reported for its antioxidant and antiviral applications, hence, it is not only used as such but also its various derivatized forms have potentials for development into drugs for the treatment of diseases caused by oxidative stress and lethal viruses.

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Anti‐inflammatory effects of natural products from vitamin C‐rich fruits

Chan,

Xiong,

Zhao

et al. 2024

Food Frontiers

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Inflammation is a crucial target for therapeutic interventions in many life‐threatening diseases, which sustains ongoing interest in the field of inflammation biology. Plant‐derived natural products, rich in phytochemicals, have been used as healing agents in several diseases since antiquity. These compounds exhibit antioxidant, anti‐inflammatory, and immunomodulatory properties, as well as gut microbiota modulation. They hold substantial potential as promising candidates for the development of novel strategies in the management of inflammation‐associated diseases. This study presents a comprehensive overview of the potential benefits given from administrating natural products (e.g., phenols, terpenes, flavonoids, and saccharides), with a particular emphasis on vitamin C‐rich fruits based on the high content of bioactive compounds with anti‐inflammatory properties. Apart from natural products, the gut microbiota acts a significant role in modulating the activation of inflammatory reaction. Deviations in its composition have been associated with various diseases. Furthermore, advancements in machine learning contribute to enhancing clinical outcomes in disease treatment. Therefore, this work provided some valuable insights in elaborating the therapeutic potential of vitamin C‐rich fruits, the role of probiotics as anti‐inflammatory agents, and the utilization of computer‐aided drug design techniques.

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Quercetin, a flavonoid with anti-inflammatory activity, suppresses the development of abdominal aortic aneurysms in mice

Cited by 65 publications

References 45 publications

Quercetin reduces oxidative stress and inhibits activation of c-Jun N-terminal kinase/activator protein-1 signaling in an experimental mouse model of abdominal aortic aneurysm

Quercetin reduces oxidative stress and inhibits activation of c-Jun N-terminal kinase/activator protein-1 signaling in an experimental mouse model of abdominal aortic aneurysm

Pharmacological Applications of Quercetin and its Derivatives: A Short Review

Anti‐inflammatory effects of natural products from vitamin C‐rich fruits

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