Quercetin improves bone strength in experimental biliary cirrhosis

Derakhshanian, Hoda; Ghadbeigi, Sajad; Rezaian, M.; Bahremand, Arash; Javanbakht, Mohammad Hassan; Golpaie, Atefeh; Hosseinzadeh, Payam; Tajik, Narges; Dehpour, Ahmad Reza

doi:10.1111/j.1872-034x.2012.01075.x

Cited by 12 publications

(8 citation statements)

References 34 publications

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“…Our study was also in agreement with finding of Hoda Derakhshanian & et al's in 2012 study where they reported that blood level of osteocalcin in rats was significantly increased after use of Quercetin for study of bone metabolic complications resulted from biliary cirrhosis indicating improving bone strength [35]. As in table 3; use of quercetin led to elevation of serum calcium, this finding is similar to finding of Marwan A.…”

Section: Discussionsupporting

confidence: 92%

Effect of Quercetin Supplement on Some Bone Mineralization Biomarkers in Diabetic Type 2 Patients

Hassan¹,

Sharrad²,

Sheri³

2018

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Background: Diabetes associated with multiple metabolic problems in the body, including bone mineralization remodeling, osteoporosis and increase risk of fracture. Quercetin is natural flavonoids and according to animal studies; it has potent antioxidant, antidiabetic and protective effect against bone loss due to various causes. Objectives: explore effect of quercetin as nutritional supplement administrated orally on some bone mineralization bio-markers such as calcium, vitamin D and osteocalcin in Iraqi diabetic patients. Methods: interventional double-blind placebo randomized controlled study in which 40 patients with type 2 diabetes mellitus (age range 40-45) assigned randomly (using simple randomization) in either control (n=20) or study (n=20) group. Study group received Quercetin oral supplement as 500mg capsule once daily for three months. Venous blood was used for measuring Serum calcium, 25(OH) vitamin D and osteocalcin at base line and after 3 months. Results: After 3 months treatment with Quercetin; levels of Osteocalcin (28.1±7.6), serum calcium (9.2±1.8) and 25(OH) vitamin D (26.6±8.7) were significantly (p<0.05) higher than pretreatment values of osteocalcin (24.0±8.6); serum calcium (7.0±2.2) and 25(OH) vitamin D (20.6±7.7) and control values of serum calcium (6.8±2.0) and 25(OH) vitamin D (20.8±7.4), but not Osteocalcin (25.2±9.0). There was also significant correlation between use of quercetin; elevation of serum calcium and osteocalcin (r= 0.454; p= 0.032), indicating modulation in bone mineralization. Conclusions: Quercetin's use in diabetic patients may elevate Serum level of Calcium; 25(OH) vitamin D and may modulate bone mineralization represented by elevation of osteocalcin.

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Section: Discussionsupporting

confidence: 92%

Effect of Quercetin Supplement on Some Bone Mineralization Biomarkers in Diabetic Type 2 Patients

Hassan¹,

Sharrad²,

Sheri³

2018

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“…Osteoporosis and increased fracture risk are common complications in patients with primary biliary cholangitis/cirrhosis. Using a rat model of osteoporosis induced by complete bile-duct ligation, the animals receiving quercetin (150 µmol/kg/day) for four weeks showed reversal of the deteriorating effects of cirrhosis on bone strength and histomorphometric indices of trabecular and cortical bones [42]. The use of high-dose vitamin A (retinoic acid) has been reported to cause reductions in BMD and structural bone parameters [61].…”

Section: Type Of Animalmentioning

confidence: 99%

Quercetin as an Agent for Protecting the Bone: A Review of the Current Evidence

Wong

Chin

2020

IJMS

143

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Quercetin is a flavonoid abundantly found in fruits and vegetables. It possesses a wide spectrum of biological activities, thus suggesting a role in disease prevention and health promotion. The present review aimed to uncover the bone-sparing effects of quercetin and its mechanism of action. Animal studies have found that the action of quercetin on bone is largely protective, with a small number of studies reporting negative outcomes. Quercetin was shown to inhibit RANKL-mediated osteoclastogenesis, osteoblast apoptosis, oxidative stress and inflammatory response while promoting osteogenesis, angiogenesis, antioxidant expression, adipocyte apoptosis and osteoclast apoptosis. The possible underlying mechanisms involved are regulation of Wnt, NF-κB, Nrf2, SMAD-dependent, and intrinsic and extrinsic apoptotic pathways. On the other hand, quercetin was shown to exert complex and competing actions on the MAPK signalling pathway to orchestrate bone metabolism, resulting in both stimulatory and inhibitory effects on bone in parallel. The overall interaction is believed to result in a positive effect on bone. Considering the important contributions of quercetin in regulating bone homeostasis, it may be considered an economical and promising agent for improving bone health. The documented preclinical findings await further validation from human clinical trials.

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“…It has been shown that estrogen enhances osteoblast differentiation and bone formation and the conditioned medium of estrogentreated osteoblast cultures inhibits osteoclast development. Many special properties of quercetin make it an ideal candidate substance for the prevention and treatment of diabetic osteopenia (9).…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Quercetin on Alveolar Bone Structure of Rats With Induced Diabetes

ayana

Elmasry

Shehata

et al. 2017

Alexandria Dental Journal

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INTRODUCTION:Diabetic osteopenia is the sixth classic complication of Diabetes mellitus. High glucose level is capable of triggering increased oxidative stress which induce osteoblast apoptosis. Quercetin, a powerful natural antioxidant, can protect many organs against oxidative damage, including bone. OBJECTIVES: The present study is designed to investigate the effect of quercetin administration on the alveolar bone in rats with induced diabetes. MATERIALS AND METHODS: Twenty-four adult male rats were divided into three equal groups (8 rats each) as follows: Group I: Control group, Group II: diabetic group (with no treatment), Group III: quercetin treated group (induction of diabetes with oral administration of quercetin dose 100mg/ kg/ day for 12 weeks). Diabetes was induced in group II and group III by a single intraperitoneal injection of Streptozotocin (STZ). After 12 weeks all rats were sacrificed and the mandibles were dissected out and prepared for histological analysis using scanning electron microscope (SEM), and energy dispersive x-ray microanalysis (EDX). RESULTS: In diabetic group, there was significant increase in blood sugar level. Bone surface revealed irregular surface with multiple resorptive pits. Moreover, there was significant decrease in calcium level and increase in phosphorous level while in quercetin group. Both blood sugar level and alveolar bone surface relatively returned back to normal. Also there was slight decrease in calcium and increase in phosphorous in comparison to control group. CONCLUSIONS: Quercetin exerts protective effects on STZ-induced oxidative stress in diabetic rats restoring the architecture of bone.

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Quercetin improves bone strength in experimental biliary cirrhosis

Abstract: These data suggest that quercetin can significantly improve bone strength particularly due to increasing bone formation in biliary cirrhosis.

Cited by 12 publications

References 34 publications

Effect of Quercetin Supplement on Some Bone Mineralization Biomarkers in Diabetic Type 2 Patients

Effect of Quercetin Supplement on Some Bone Mineralization Biomarkers in Diabetic Type 2 Patients

Quercetin as an Agent for Protecting the Bone: A Review of the Current Evidence

Efficacy of Quercetin on Alveolar Bone Structure of Rats With Induced Diabetes

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