R-cadherin: A novel Ca2+-dependent cell-cell adhesion molecule expressed in the retina

Inuzuka, Hiroyuki; Miyatani, Seiji; Takeichi, Masatoshi

doi:10.1016/0896-6273(91)90075-b

Cited by 210 publications

(159 citation statements)

References 24 publications

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“…Cadherin-4 (Cdh4), also called R-cadherin, is a member of the type-I classical cadherin subfamily (Redies, 1995;Nollet et al, 2000). Cdh4 expression and/or function in the vertebrate nervous system has been studied in a variety of vertebrate species including zebrafish, Xenopus, chicken, and mouse (Inuzuka et al, 1991;Redies et al, 1992;Ganzler and Redies, 1995;Matsunami and Takeichi, 1995;Tashiro et al, 1995;Liu et al, 1999;Wohrn et al, 1998;Gerhardt et al, 2000;Honjo et al, 2000;Treubert-Zimmermann et al, 2002;Andrews and Mastick, 2003;Babb et al, 2005). We previously showed that Cdh4/cdh4 is expressed in the majority of the cranial and lateral line ganglia and their nerves in the developing zebrafish (Liu et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Cadherin‐4 plays a role in the development of zebrafish cranial ganglia and lateral line system

Wilson

Shen

Clendenon

et al. 2007

Developmental Dynamics

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We previously reported that cadherin-4 (also called R-cadherin) was expressed by the majority of the developing zebrafish cranial and lateral line ganglia. Cadherin-4 (Cdh4) function in the formation of these structures in zebrafish was studied using morpholino antisense technology. Differentiation of the cranial and lateral line ganglia and lateral line nerve and neuromasts of the cdh4 morphants was analyzed using multiple neural markers. We found that a subset of the morphant cranial and lateral line ganglia were disorganized, smaller, with reduced staining, and/or with altered shape compared to control embryos. Increased cell death in the morphant ganglia likely contributed to these defects. Moreover, cdh4 morphants had shorter lateral line nerves and a reduced number of neuromasts, which was likely caused by disrupted migration of the lateral line primordia. These results indicate that Cdh4 plays a role in the normal formation of the zebrafish lateral line system and a subset of the cranial ganglia. Developmental Dynamics 236:893-902, 2007.

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Section: Introductionmentioning

confidence: 99%

Cadherin‐4 plays a role in the development of zebrafish cranial ganglia and lateral line system

Wilson

Shen

Clendenon

et al. 2007

Developmental Dynamics

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“…They named these cadherins numerically from cadherin-4 to cadherin-13, and so far seven of them have been completely sequenced (11)(12)(13)28); cadherin-4 is the human homologue of R-cadherin (29), and cadherin-13, which lacks a cytoplasmic domain, seems to be the human homologue of T-cadherin (30). Cadherin-5, -6, -8, -11, and -12 have similar structures and high amino acid homology with each other, suggesting that they form a subgroup of cadherins called type II cadherins.…”

Section: The Nucleotide Sequence(s) Reported In This Paper Has Been Smentioning

confidence: 99%

Identification of Human Cadherin-14, a Novel Neurally Specific Type II Cadherin, by Protein Interaction Cloning

Shibata¹,

Shimoyama²,

Gotoh³

et al. 1997

Journal of Biological Chemistry

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Cadherins, a family of Ca 2؉ -dependent cell-cell adhesion molecules, mediate neural cell-cell interactions and may play important roles in neural development. By searching for molecules that interact with ␤-catenin, a cytoplasmic regulator of cadherins, we have identified a new member of the cadherin family, which we named human cadherin-14. Cadherin-14 had high amino acid sequence homology with the type II subgroup of cadherins and was broadly expressed in the central nervous system. Cadherin-14 is a novel neurally specific cell-cell adhesion molecule and may regulate neural morphogenesis.

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“…It has been shown that N-cadherin plays an important role in the early morphogenesis of neural tissues (Matsunaga et al, 1988b;Detrick et al, 1990;Fujimori et al, 1990). N-cadherin also mediates selective adhesiveness between neural cells (Miyatani et al, 1989), and induces axon outgrowth and fasciculation (Bixby et al, 1987;Matsunaga et al, 1988a;Neugebauer et al, 1988;Tomaselli et al, 1988;Letourneau et al, 1990;Drazba and Lemmon, 1990;Bixby and Zhang, 1990;Doherty et al, 1991;Inuzuka et al, 1991a;Redies et al, 1992). In embryonic chicken brain, N-cadherin expression is relatively uniform in the early neuroepithelium but, at later stages, it becomes restricted to particular functional systems of the CNS .…”

Section: Introductionmentioning

confidence: 99%

“…In embryonic chicken brain, N-cadherin expression is relatively uniform in the early neuroepithelium but, at later stages, it becomes restricted to particular functional systems of the CNS . Finally, N-cadherin is expressed in several ependymal structures of the CNS (Inuzuka et al, 1991a;Lagunowich et al, 1992;.…”

Section: Introductionmentioning

confidence: 99%

Expression of N‐cadherin mRNA during development of the mouse brain

Redies

Takeichi

1993

Developmental Dynamics

109

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The expression of N-cadherin mRNA was mapped in the brain of mice between embryonic day 12 (E12) and the adult stage by in situ hybridization of digoxigenin-labeled riboprobe. Two phases of N-cadherin expression can be distinguished. During the first phase (about E l 2 to E16), expression is ubiquitous throughout the brain and most prominent in the proliferative neuroepithelium. During the second phase (about El6 to postnatal day 6), N-cadherin expression is restricted to particular nuclei or laminae that share common functional features and neuroanatomical connections. Several of the N-cadherinpositive structures receive direct afferents from retinal ganglion cells or from the superior colliculus. Others belong to the reticular system and to the limbic system of the brain. In neocortex, N-cadherin is expressed by deeper layer cells. In the adult brain, only low levels of N-cadherin expression remain in very few types of cells, for example in the Purkinje cells of the cerebellum.These results are similar to data from chicken brain and suggest that the generalized expression of N-cadherin during the early phase and the restriction expression of this molecule in particular functional systems during the later phase is, at least in part, phylogenetically conserved between chicken and mouse. Moreover, the results show that N-cadherin expression extends to phylogenetically newer structures, e.g., the mammalian neocortex. 0 1993 Wiley-Liss, Inc.

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R-cadherin: A novel Ca2+-dependent cell-cell adhesion molecule expressed in the retina

Cited by 210 publications

References 24 publications

Cadherin‐4 plays a role in the development of zebrafish cranial ganglia and lateral line system

Cadherin‐4 plays a role in the development of zebrafish cranial ganglia and lateral line system

Identification of Human Cadherin-14, a Novel Neurally Specific Type II Cadherin, by Protein Interaction Cloning

Expression of N‐cadherin mRNA during development of the mouse brain

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